INT-AN: Interoception in Anorexia Nervosa
Study Details
Study Description
Brief Summary
Anorexia nervosa is a serious psychiatric illness whose causes remain poorly understood, and which remains difficult to treat to this day. Many clinical manifestations of this disease can have their origin in abnormalities in the perception of signals coming from inside the body, but this remains to be demonstrated. In recent years, research in healthy subjects has shown how the brain constantly perceives the viscera (heart, lungs, stomach). The examiners will use these new, objective and validated methods to explore how the brain processes information from the viscera (interoception) in anorexic patients. In practice, they will quantify the coupling between the cardiac cycle and involuntary eye movements, as well as between the respiratory cycle and voluntary actions such as pressing a button. Finally, by simultaneously recording the electrical activity of the brain, and that of the stomach, the examiners will measure the coupling between the brain and the stomach. All these measurements, which will be compared between a population of patients and healthy subjects, will make it possible to determine whether anorexic patients have an alteration in the perception of their internal body signals and whether this damage affects several organs.
Condition or Disease | Intervention/Treatment | Phase |
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Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Control Females Age : matched for the AN group No present or past eating disorders No past or current psychotic disorders No current substance abuse or dependence. No current psychiatric medication |
Other: Clinical and experimental session
Psychologic profile with standardized interview and scales (see below for details: SCID, BDI, STAI, BPQ, EDE Q, Pictorial Body Image Scale (PBIS) and EDI).
Measure the stomach-brain synchrony during EEG/EGG resting state, the distribution of voluntary actions across the respiratory phase, and the distribution of saccadic eye movements across the cardiac-cycle.
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AN group Females 16 years ≤ Age ≤ 25 years Diagnostic of AN according to DSM-5 criteria No past or current psychotic disorders No current substance abuse or dependence (excluding tobacco). No current psychiatric medication |
Other: Clinical and experimental session
Psychologic profile with standardized interview and scales (see below for details: SCID, BDI, STAI, BPQ, EDE Q, Pictorial Body Image Scale (PBIS) and EDI).
Measure the stomach-brain synchrony during EEG/EGG resting state, the distribution of voluntary actions across the respiratory phase, and the distribution of saccadic eye movements across the cardiac-cycle.
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Outcome Measures
Primary Outcome Measures
- measure brain-stomach interactions using phase-amplitude coupling between the gastric phase and the amplitude of the cortical alpha rhythm. [Experimental session - 10 days maximum after inclusion]
Examiners will directly measure brain-stomach interactions using phase-amplitude coupling between the gastric phase and the amplitude of the cortical alpha rhythm.
Eligibility Criteria
Criteria
Inclusion Criteria - AN groups:
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Females
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6 to 25 years old
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Diagnostic of AN according to DSM-5 criteria
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No past or current psychotic disorders
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No current substance abuse or dependence (excluding tobacco).
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No current psychiatric medication
Inclusion Criteria - control groups:
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Females
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Age : matched for the AN group
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No present or past eating disorders
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No past or current psychotic disorders
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No current substance abuse or dependence.
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No current psychiatric medication
Exclusion Criteria for both groups:
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age below 16 years and above 25 years,
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Past or current psychotic disorders,
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Current substance abuse or dependence (excluding tobacco)
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Opposition to participation has been expressed.
In addition, for the control group,
- Subjects with present or past eating disorders or current mental disorders will be excluded.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | ENS | Paris | Ile De France | France | 75005 |
Sponsors and Collaborators
- Fondation Santé des Étudiants de France
- Laboratoire de Psychologie et NeuroCognition
- University Hospital, Geneva
Investigators
- Principal Investigator: Marco Solca, Dr, ENS
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2021-A00811-40