Fiber Fermentation Study
Study Details
Study Description
Brief Summary
The aim of the study is to better understand the interplay between the intake of dietary fiber and intestinal bacteria, their metabolic activity and the effect on the intestinal barrier.
The effect of two different dietary fiber supplements is tested (arabinoxylan & ß-glucan versus inulin & fructooligosaccharides) in a randomized crossover intervention trial including healthy volunteers.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: 1 This arm received the arabinoxylan/ß-glucan mix first. |
Dietary Supplement: Dietary fiber supplementation
16g/day: mix of 70% wheat-bran arabinoxylan and 30% oat-derived fiber (ß-glucan)
16g/day: mix of 50% inulin and 50% oligofructose from chicory
|
Experimental: 2 This arm received the inulin/oligofructose mix first. |
Dietary Supplement: Dietary fiber supplementation
16g/day: mix of 70% wheat-bran arabinoxylan and 30% oat-derived fiber (ß-glucan)
16g/day: mix of 50% inulin and 50% oligofructose from chicory
|
Outcome Measures
Primary Outcome Measures
- Short-chain fatty acids (SCFAs) [Will be measured in approx. 4 weeks after study completion.]
SCFAs in native fecal samples
Secondary Outcome Measures
- Gut microbiome composition [Will be measured in approx. 6-8 weeks after study completion.]
16S NGS sequencing
- Gut barrier integrity [Will be measured in approx. 4 weeks after study completion.]
Lipopolysaccharide-binding protein (plasma) and zonulin (feces)
Eligibility Criteria
Criteria
Inclusion Criteria:
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18 to 65 years
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signed written informed consent
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willingness not to change the dietary pattern in the course of the study
Exclusion Criteria:
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BMI below 18 or above 30
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acute or chronic gastrointestinal symptoms
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neoplastic diseases
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very strict diets, including raw foodists and frutarians
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regular smoking (more than one box per day)
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intake of antibiotics, immunosuppressants, or any intestinal therapeutics three months prior to study begin
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supplementation of fibers three months prior to study begin
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simultaneous participation in another clinical study
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pregnancy / breastfeeding
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relevant violations of the study protocol
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intolerance to the fiber supplements (including wheat, oat, chicory)
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occurrence of relevant diseases (individual decision by study physicians)
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revocation of consent
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placement in a clinic or similar facility based on an official or court order
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Institute of Nutritional Medicine, University of Hohenheim | Stuttgart | Germany | 70599 |
Sponsors and Collaborators
- University of Hohenheim
Investigators
- Principal Investigator: Stephan C Bischoff, Prof., MD, University of Hohenheim, Institute of Nutritional Medicine
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- FiberStudy