(IFS/IBDS): Iowa Fluoride Study/Iowa Bone Development Study
Study Details
Study Description
Brief Summary
A cohort of newborns was recruited for the Iowa Fluoride Study from 1992-95 to assess the complex relationships among fluoride intakes, fluoride exposures, dental fluorosis, and dental caries. Detailed questionnaires were sent every 1.5-6 months concerning water sources, fluoride exposures, dietary intakes, etc. Standardized dental exams were conducted at ~ages 5, 9, 13, 17, and 23. At about age 5, participants were invited to join the offshoot Iowa Bone Development Study. Bone densitometry assessments were conducted at ages 5, 8, 11, 13, 15, 17, 19, and 23. These included Dual-energy X-ray Absorptiometry (DXA) of hip, lumbar spine, and whole body from age 5; peripheral Quantitative Computed Tomography (pQCT) of the radius and tibia from age 11; and Multi-Detector Computed Tomography (MDCT) of the tibia from age 19. Physical activity and other factors also were assessed longitudinally.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
A cohort of newborns was recruited for the Iowa Fluoride Study from 1992-95 to assess the complex relationships among fluoride intakes, fluoride exposures, dental fluorosis, and dental caries. Detailed questionnaires were sent every 1.5-6 months concerning water sources, fluoride exposures, dietary intakes, etc. Standardized dental exams were conducted at ~ages 5, 9, 13, 17, and 23. At about age 5, participants were invited to join the offshoot Iowa Bone Development Study. Bone densitometry assessments were conducted at ages 5, 8, 11, 13, 15, 17, 19, and 23. These included Dual-energy X-ray Absorptiometry (DXA) of hip, lumbar spine, and whole body from age 5; peripheral Quantitative Computed Tomography (pQCT) of the radius and tibia from age 11; and Multi-Detector Computed Tomography (MDCT) of the tibia from age 19. Physical activity and other factors also were assessed longitudinally.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Parents with newborns recruited from 1992-5 Parents of newborns recruited from 8 Iowa hospitals in 1992-5 |
Outcome Measures
Primary Outcome Measures
- dental fluorosis-5 [age 5]
dental fluorosis exam results
- dental fluorosis-9 [age 9]
dental fluorosis exam results
- dental fluorosis-13 [age 13]
dental fluorosis exam results
- dental fluorosis-17 [age 17]
dental fluorosis exam results
- dental fluorosis-23 [age 23]
dental fluorosis exam results
- dental caries-5 [age 5]
dental caries exam results
- dental caries-9 [age 5]
dental caries exam results
- dental caries-13 [age 9]
dental caries exam results
- dental caries-17 [age 17]
dental caries exam results
- dental caries-23 [age 23]
dental caries exam results
- bone densitometry-5 [age 5]
DXA scans
- bone densitometry-8 [age 8]
DXA scans
- bone densitometry-11 [age 11]
DXA and pQCT scans
- bone densitometry-13 [age 13]
DXA and pQCT scans
- bone densitometry-15 [age 15]
DXA and pQCT scans
- bone densitometry-17 [age 17]
DXA and pQCT scans
- bone densitometry-19 [age 19]
DXA, pQCT, and MDCT scans
- bone densitometry-23 [age 23]
DXA, pQCT, and MDCT scans
Eligibility Criteria
Criteria
Inclusion Criteria:
- healthy newborn
Exclusion Criteria:
- not health newborn
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Steven M Levy
Investigators
- Principal Investigator: Steven M Levy, dds, University of Iowa
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 199112665