Efficacy of Ketamine in Post Anesthesia Recovery Room

Sponsor

University of Alberta (Other)

Overall Status

Completed

CT.gov ID

NCT04701008

Collaborator

(none)

143

Enrollment

Location

8.8

Actual Duration (Months)

16.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Observational study to assess efficacy of IV ketamine bolus when used in the post anesthesia recovery unit for uncontrolled pain despite use of opioids.

Condition or Disease	Intervention/Treatment	Phase
Pain, Postoperative Ketamine Adverse Reaction Pain, Refractory Pain, Intractable Pain, Acute	Drug: Ketamine

Detailed Description

In this observational study, the investigators will monitor all patients with significant pain after any non-cardiac surgical intervention at the University of Alberta Hospital.

After receiving an adequate dose of potent opioids (hydromorphone, morphine), the participants will receive up to 0,2-0,25 mg/kg IV ketamine bolus. In our center these boluses are given with 10-20mg increments.

The adequate dose of opioids will be determined by the attending anesthesiologist, depending on what patients received intraoperatively and on their comorbidities.

Pain scores will be assessed before and after administration of this drug. The incidence of any side effect after ketamine administration will be documented.

Study Design

Study Type:

Observational

Actual Enrollment :

143 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Observational Study of the Efficacy of Ketamine for Rescue Analgesia in the Post Anesthesia Recovery Room

Actual Study Start Date :

Sep 1, 2020

Actual Primary Completion Date :

May 28, 2021

Actual Study Completion Date :

May 28, 2021

Arms and Interventions

Arm	Intervention/Treatment
Patients with significative post-operative pain despite Patients with significant pain despite receiving narcotics in PACU will receive a bolus dose of IV ketamine to assess its efficacy for pain score reduction. Bolus doses are given by 10mg IV increments, to reach approximate dose of 0,25mg/kg.	Drug: Ketamine IV ketamine - 10mg bolus may be repeated repeated 2-3 times depending on clinical judgement

Arm

Intervention/Treatment

Patients with significative post-operative pain despite

Patients with significant pain despite receiving narcotics in PACU will receive a bolus dose of IV ketamine to assess its efficacy for pain score reduction. Bolus doses are given by 10mg IV increments, to reach approximate dose of 0,25mg/kg.

Drug: Ketamine

IV ketamine - 10mg bolus may be repeated repeated 2-3 times depending on clinical judgement

Outcome Measures

Primary Outcome Measures

Reduction in pain score after ketamine use in PACU [in the immediate post-operative period in recovery room]
The Numeric Rating Scale (NRS-11) is an 11-point scale for patient self-reporting of pain. It is what is used most often in our recovery room for pain assessment. A score of 0/10 means no pain, and 10/10 means worst pain.

Secondary Outcome Measures

Incidence of side effects after ketamine use [in the immediate post-operative period in recovery room]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Adult patients undergoing non cardiac surgery at University of Alberta Hospital meeting the following criteria:

age ≥ 18
significant pain despite narcotics used in post-anesthesia care unit
ketamine ordered by attending anesthesiologist

Exclusion Criteria:

Patient refusal to receive ketamine
Patients undergoing cardiac surgery
Patients who received no narcotics
Contra-indication to receiving ketamine (determined by attending anesthesiologist)