KIDNAP: Key to Improve DiagNosis in Aspiration Pneumonia
Study Details
Study Description
Brief Summary
To evaluate the diagnostic performance of amylase assay performed from bronchial alveolar fluid to differentiate aseptic chemical inhalation pneumonitis from an infectious inhalation pneumonitis in comatose patients with intubated ventilation for less than 24 hours.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Validation of the potential diagnostic performance of amylase assay compared to gold standard in diagnosis of infectious inhalation pneumonia of the comatose patient enabling the realization of a multicentric study using this innovative method in a diagnostic strategy with the objective of reducing the consumption of antibiotics.
Study Design
Outcome Measures
Primary Outcome Measures
- Sensitivity and specificityof amylase test. [5 days after inclusion day]
Amylase culture in bronchoalveolar fluid is compared to gold standard culture
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patient intubated ≤ 24 hours for unconsciousness (stroke, meningitis, drug intoxication, metabolic disorders, epilepticus, cardiac arrest).
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Inhalation table with hypoxemic acute respiratory insufficiency post-consciousness + chest x-ray revealing one or more compatible infiltrates + t °> 38 ° C).
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Age ≥18 years
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Patient affiliated to the social security system.
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No opposition obtained
Exclusion Criteria:
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Immunocompromised patient.
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Cardiorespiratory arrest requiring therapeutic hypothermia.
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Pneumopathy nosocomiale (pneumopathy beginning> 48h after hospital admission).
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Infectious Pneumonia in the previous 30 days.
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Previous hospitalization in the previous 30 days.
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Patient under antibiotic at baseline.
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Bacteremia.
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Mechanical ventilation begun before unconsciousness.
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Report Pa02 / FI02 <80.
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Patient under curatorship and / or guardianship.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Hôpital Pellegrin | Bordeaux | France | 33000 |
Sponsors and Collaborators
- University Hospital, Bordeaux
Investigators
- Study Chair: Linda Wittkop, PhD, USMR
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- CHUBX 2015/38