A Study of Lenalidomide for Adult Histiocyte Disorders

Sponsor

Dana-Farber Cancer Institute (Other)

Overall Status

Active, not recruiting

CT.gov ID

NCT02523040

Collaborator

Celgene (Industry)

Enrollment

Location

Arm

Duration (Months)

0.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This research study is studying a chemotherapy drug Lenalidomide as a possible treatment for one of three histiocyte disorders: Langerhans cell histiocytosis (LCH), Erdheim-Chester disease (ECD), or histiocytic sarcoma (HS).

Condition or Disease	Intervention/Treatment	Phase
Langerhans Cell Histiocytosis (LCH) Histiocytoses Erdheim-chester Disease Histiocytic Sarcoma (HS)	Drug: Lenalidomide	Phase 2

Detailed Description

This research study is a Phase II clinical trial. Phase II clinical trials test the safety and effectiveness of an investigational intervention to learn whether the intervention works in treating a specific disease. "Investigational" means that the intervention is being studied.

The FDA (the U.S. Food and Drug Administration) has not approved lenalidomide for your specific disease but it has been approved for other uses. Lenalidomide is a chemotherapy drug that belongs to a class of drugs called immunomodulatory drugs (IMiDs), which modify a participant's immune response in order to treat cancer. Lenalidomide alters the body's immune system and it may also interfere with the development of tiny blood vessels that help support tumor growth. Therefore, it may reduce or prevent the growth of cancer cells. Lenalidomide has been shown to restore the immune cells' ability to attack and kill tumor cells Lenalidomide is approved by the FDA to treat certain cancers including multiple myeloma and myelodysplastic syndrome.

Study Design

Study Type:

Interventional

Anticipated Enrollment :

12 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

A Phase II Study of Lenalidomide for Adult Histiocyte Disorders

Study Start Date :

Aug 1, 2015

Anticipated Primary Completion Date :

Feb 1, 2023

Anticipated Study Completion Date :

Sep 1, 2023

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Lenalidomide After the screening procedures confirm participation in the research study. - Lenalidomide Oral, Daily for 21 days of each cycle	Drug: Lenalidomide Other Names: Revlimid

Arm

Intervention/Treatment

Experimental: Lenalidomide

After the screening procedures confirm participation in the research study. - Lenalidomide Oral, Daily for 21 days of each cycle

Drug: Lenalidomide

Other Names:

Revlimid

Outcome Measures

Primary Outcome Measures

Response Rate [12 Months]

Secondary Outcome Measures

Progression Free Survival (PFS) [12 Months]
Overall Survival [12 Months]
Number of Participating with Grade 3-4 toxicity [12 Months]
Quantitative serial measurements of urine cell free DNA for BRAF mutation as a biomarker of response [12 Months]
Quantitative serial measurements of serum TNF-alpha levels as a biomarker of response [12 Months]
Quantitative serial measurements of plasma cell free DNA for BRAF mutation as a biomarker of response [12 months]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Patients must have histologically or cytologically confirmed LCH, ECD or HS. Confirmation of outside pathology at BWH will be performed but is not mandatory prior to study enrollment (see section 3).
Detectable disease by at least one of the following modalities: CT, PET, bone scan, or MRI.
Patients with LCH must require systemic therapy according to the Histiocyte Society LCH Evaluation and Treatment Guidelines (HS 2009)

-- Or

Patients with HS requiring systemic treatment as defined by disease that cannot be surgically resected and/or encompassed in a single radiation field.
Age 18 years or older.
ECOG performance status ≤2 (Karnofsky ≥60%, see Appendix A)
Participants must have normal organ and marrow function as defined below:
absolute neutrophil count ≥1,000/mcL
platelets ≥100,000/mcL
total bilirubin within 1.5 times normal institutional limits
AST(SGOT)/ALT(SGPT) ≤3 × institutional upper limit of normal
creatinine within 2 times normal institutional limits

--- OR

creatinine clearance ≥30 mL/min/1.73 m2. Note, dose adjustments are required for CrCl ≥30 mL/min but ≤60 ml/min.
Able to take aspirin 81 mg daily as prophylactic anticoagulation if not on warfarin, low molecular weight heparin or oral factor Xa inhibitor. Patients intolerant to ASA may use warfarin or low molecular weight heparin at doses designed to treat deep venous thrombosis.
All study participants must be registered into the mandatory Revlimid REMS® program, and be willing and able to comply with the requirements of the REMS® program.
Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation.
Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

Prior chemotherapy or radiation within 2 weeks (6 weeks for nitrosoureas or mitomycin

prior to entering the study or those who have not recovered from adverse events due to agents administered more than 2 weeks earlier.

Participants who are receiving any other investigational agents.
Prior treatment with lenalidomide. Patients previously treated with thalidomide who discontinued treatment for reasons aside from an adverse reaction to thalidomide are permitted.
History of another invasive malignancy unless treated with curative intent 5 years or more prior to study entry. Patients with localized carcinoma of the cervix, non-melanoma skin cancer, or early stage prostate cancer requiring observation only are eligible regardless of timing of diagnosis.
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
Pregnant women are excluded from this study because lenalidomide has known teratogenic effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with lenalidomide, breastfeeding should be discontinued if the mother is treated with lenalidomide.
Known active hepatitis B (HBV) or hepatitis C (HCV) infection. Patients who are positive only for HBV surface antibody as a result of prior vaccination are eligible. Patients with a positive HBV core antibody but undetectable HBV viral load are eligible.
HIV-positive participants on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with lenalidomide. In addition, these participants are at increased risk of lethal infections when treated with marrow-suppressive therapy. Appropriate studies will be undertaken in participants receiving combination antiretroviral therapy when indicated.
Concomitant corticosteroids unless patient has been on a stable dose of prednisone (or equivalent) of ≤10 mg daily for at least 2 weeks prior to first dose of study drug.
Inability to swallow pills.