Treatment of Leukemia and Lymphoma in Children With Ataxia Telangiectasia

Sponsor
Rabin Medical Center (Other)
Overall Status
Recruiting
CT.gov ID
NCT04037189
Collaborator
Israeli Society for Pediatric Hematology-Oncology (Other), International BFM Study Group (Other)
250
1
29.1
8.6

Study Details

Study Description

Brief Summary

Ataxia telangiectasia (A-T) is a multisystem disease with diverse manifestations, including progressive neurodegeneration, immunodeficiency, respiratory disease, and genomic instability. One of the most important features of A-T is the increased predisposition to cancer, especially to lymphoid malignancies. Patients with A-T are generally excluded from collaborative clinical trials, their treatment outcomes and toxicity profiles have rarely been reported, and little is currently known concerning the treatment intensity required to provide a reasonable balance between efficacy and toxicity. The aims of this study are to build a large international de-identified database of children with A-T treated for leukemia and lymphoma, to investigate epidemiology and outcome of treatment, toxicity profiles and risk factors which impact outcome, in order to eventually enable the generation of data-based treatment recommendations for this population.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Ataxia telangiectasia (A-T) is a multisystem disease with diverse manifestations, including progressive neurodegeneration, immunodeficiency, respiratory disease, and genomic instability. A-T is caused by biallelic mutations in the ATM gene, a major activator of the cellular response to DNA double strand breaks. One of the most important features of A-T is the increased predisposition to cancer. Lymphoid malignancies represent the majority of cancers. The treatment of cancer in children with A-T is extremely challenging, due to severe co-morbidities and a significantly increased risk of cancer therapy-related toxicities. Patients with A-T are generally excluded from collaborative clinical trials, their treatment outcomes and toxicity profiles have rarely been reported, and little is currently known concerning the treatment intensity required to provide a reasonable balance between efficacy and toxicity. The optimal treatment approach is controversial; some advocate treatment by standard chemotherapeutic protocols, while others advise initial protocol modifications with chemotherapy dose reductions. Due to the rarity of this disorder, there is an unmet need for an international collaboration for data collection concerning treatment, toxicity and outcome in children with cancer and A-T. Data will be collected from patient files, including patient characteristics and history, AT manifestations, malignancy characteristics, treatment, chemotherapy doses, treatment response, toxicity and outcome.

    The aims of the study are to build a large international de-identified database of children with A-T treated for leukemia and lymphoma, to investigate epidemiology and outcome of treatment, toxicity profiles and risk factors which impact outcome, in order to eventually enable the generation of data-based treatment recommendations for this population.

    This study will not involve the use of specimens or participant contact. All the data required have already been collected during the treatment of the participants, and is available in patient records.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    250 participants
    Observational Model:
    Cohort
    Time Perspective:
    Retrospective
    Official Title:
    Treatment of Leukemia and Lymphoma in Children With Ataxia Telangiectasia- A Retrospective Study
    Actual Study Start Date :
    Jul 28, 2019
    Anticipated Primary Completion Date :
    Oct 28, 2021
    Anticipated Study Completion Date :
    Dec 30, 2021

    Outcome Measures

    Primary Outcome Measures

    1. Event-free survival [5 years]

      Assess 5 and 3-year event-free survival

    2. Overall survival [5 years]

      Assess 5 and 3-year overall survival

    3. Cumulative incidence of relapse [5 years]

      Assess 5-year cumulative incidence of leukemia/lymphoma relapse

    4. Cumulative incidence of treatment-related mortality [2 years]

      Assess 2-year cumulative incidence of treatment-related mortality

    5. Cumulative incidence of second malignancies [5 years]

      Assess 5-year cumulative incidence of second malignancies

    Secondary Outcome Measures

    1. Cause and timing of death [5 years]

      Determine cause of death and timing of death in relation to specific elements of leukemia/lymphoma therapy (by questionnaire)

    2. Number of participants with treatment-related adverse events as assessed by CTCAE v4.0 [2 years]

      Number of participants with treatment-related adverse events as assessed by CTCAE v4.0

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    0 Years to 21 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • Individuals diagnosed with ataxia telangiectasia and leukemia or lymphoma

    • Age 0-21

    Exclusion Criteria:

    -Age greater than 21 years

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Schneider Children's Medical Center Petah Tikva Israel 4920235

    Sponsors and Collaborators

    • Rabin Medical Center
    • Israeli Society for Pediatric Hematology-Oncology
    • International BFM Study Group

    Investigators

    • Principal Investigator: Sarah Elitzur, MD, Schneider Children's Medical Center, Israel

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Rabin Medical Center
    ClinicalTrials.gov Identifier:
    NCT04037189
    Other Study ID Numbers:
    • 0132-19-RMC
    First Posted:
    Jul 30, 2019
    Last Update Posted:
    Oct 1, 2021
    Last Verified:
    Aug 1, 2021
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Oct 1, 2021