Relationship Between Liver Cancer and Sarcopenia

Sponsor

First Affiliated Hospital of Wenzhou Medical University (Other)

Overall Status

Enrolling by invitation

CT.gov ID

NCT05339919

Collaborator

Qilu Hospital of Shandong University (Other), The Second Hospital of Shandong University (Other)

1,200

Enrollment

Location

63.9

Anticipated Duration (Months)

18.8

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

By tracking the short-term and long-term results of patients after hepatectomy, the difference of short-term results between patients with sarcopenia and patients without sarcopenia was analyzed, and the correlation between sarcopenia and short-term and long-term results of patients after hepatectomy was explored, so as to improve people's awareness of sarcopenia and pay attention to its prevention and treatment.

Condition or Disease	Intervention/Treatment	Phase
Liver Cancer Sarcopenia	Diagnostic Test: gait speed; ct scan;grip strength and chair stand test

Detailed Description

All implementation details are based on the newest EWGSOP definition. The investigators consecutively admitted patients the questionnaire and evaluated the assessment of muscle strength (grip strength test and chair stand test), muscle quantity (L3 plane total skeletal muscle area) and physical performance (gait test) following the F-A-C-S approach, to confirm patients with sarcopenia accurately. And by tracking the short-term and long-term outcomes of patients after hepatectomy, the differences were analyzed and the relationship between sarcopenia and liver cancer was explored.

Study Design

Study Type:

Observational [Patient Registry]

Anticipated Enrollment :

1200 participants

Observational Model:

Case-Control

Time Perspective:

Prospective

Official Title:

The Effect of Sarcopenia on Hepatocellular Carcinoma After Hepatectomy

Actual Study Start Date :

May 1, 2020

Actual Primary Completion Date :

Aug 11, 2021

Anticipated Study Completion Date :

Aug 28, 2025

Outcome Measures

Primary Outcome Measures

Short-term postoperative results [3 months]
Postoperative complications；90 days readmission rate
Long-term results after operation [10 years]
Overall survival; Disease free survival

Secondary Outcome Measures

Postoperative hospitalization time [2 months]
Time window from the day of operation to the day of discharge.
Hospitalization expenses [2 months]
All hospitalization expenses, including drug expenses, operation expenses, anesthesia expenses, nursing expenses and other expenses.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Patients with preoperative clinical diagnosis of liver cancer
No cancer other than liver cancer has been diagnosed
Age ≥18 years

Exclusion Criteria:

Patients who could not complete the standard tests and questionnaires
Patients who did not accept liver resection after evaluation of treatment plan
Patients who had other concomitant preoperative causes of muscle weakness (injury, fracture, stroke, etc.)
Patients who missing CT data or CT scan did not reach the level of the third lumbar vertebra (L3)