Effect of Dexmedetomidine as Adjuvant to Ropivacaine for Brachial Plexus Block
Study Details
Study Description
Brief Summary
Brachial plexus block is used for upper limb surgery. Local anesthesia alone for brachial plexus block provides good operative conditions, but have short duration of postoperative analgesia. Hence, various adjuvants to local anaesthetic agents to prolong the duration of peripheral nerve, analgesia. However, results are either inconclusive or associated with side effects. The purpose of this study is to determine whether dexmedetomidine as an adjuvant to ropivacaine in brachial plexus block improve quality of block in terms of duration of post operative analgesia.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Active Comparator: Group R 0.35% ropivacaine 20ml, 1.5% lidocaine with adrenaline 10ml = 30 ml |
Drug: ropivacaine, lidocaine with adrenaline
Group R includes 0.35% ropivacaine 20ml, 1.5 % lidocaine with adrenaline 10ml
|
Experimental: Group RD 0.35% ropivacaine and 1mcg/ kg dexmedetomidine (20 ml), 1.5% lidocaine with adrenaline (10ml) = 30 ml |
Drug: Dexmedetomidine, ropivacaine, lidocaine with adrenaline
Dexmedetomidine 1mcg/kg and 0.35% ropivacaine with normal saline (20ml), 1.5% lidocaine with adrenaline (10ml) in group RD
|
Outcome Measures
Primary Outcome Measures
- Assess the duration of analgesia after brachial plexus block with ropivacaine and dexmedetomidine [5 months]
Analgesia will be assessed with the help of Visual analogue score ( VAS). VAS greater than 3 will be given inj.ketorolac 30mg IV.
- Assess the onset of sensory and motor block after brachial plexus block with ropivacaine and dexmedetomidine [5 months]
Sensory block assessed by 3point scale 0 normal sensation loss of sensation of pinprick loss of sensation of touch Duration of sensory block, defined as time interval between complete sensory block and complete resolution of anesthesia (score 0).Motor blockade assessed by modified Bromage scale (MBS) 0-able to raise extended arm to 90 degree for full two seconds able to flex elbow, move fingers but unable to raise extended arm unable to flex elbow but able to move fingers unable to move arm, elbow, fingers Duration of motor block defined as time interval from complete motor block to recovery of complete motor function (MBS 0).
- Assess the duration of sensory and motor block after brachial plexus block with ropivacaine and dexmedetomidine [5months]
Duration of sensory block, defined as time interval between complete sensory block and complete resolution of anesthesia (score 0). Duration of motor block defined as time interval from complete motor block to recovery of complete motor function (MBS 0).
Secondary Outcome Measures
- Assess any complications of study drugs [5 months]
Complications like bradycardia assessed by continue ECG monitoring, Hypotension will be assessed by NIBP
Eligibility Criteria
Criteria
Inclusion Criteria:
-
ASA physical status I and II patients, weight 45 to 74 kg
-
Elective upper limb surgery under brachial plexus block
Exclusion Criteria:
-
known hypersensitivity or contraindication to ropivacaine, lidocaine and dexmedetomidine
-
Pregnant or lactating mothers
-
Hepatic, renal or cardiopulmonary abnormalities
-
Long term analgesic therapy
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Nepal medical college | Kathmandu | Bagmati | Nepal | 0096 |
Sponsors and Collaborators
- Nepal Medical College and Teaching Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NepalMCTH