Screening for Lung Cancer in Subjects With Family History of Lung Cancer
Study Details
Study Description
Brief Summary
Lung cancer can be detected via screening of high-risk individuals, i.e current or ex-heavy smokers, with low-dose computer tomography (LDCT) of thorax. The National Lung Screening Trial in US and the NELSON trial in Europe demonstrated reduction in lung cancer mortality with LDCT screening for lung cancer. In Hong Kong, however, there is a prominence of female never-smokers with lung cancer. There is no identifiable risk factors for non-smokers with lung cancer except family history of lung cancer. The hypothesis is that lung cancer screening for subjects with family history of lung cancer, can detect early lung cancer.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
The primary aim of this prospective study is to find out the rate of lung cancer detection in subjects who are first degree relatives of lung cancer patients. Secondary aims include studying the characteristics of screen-detected lung cancer. This is a multi-centered prospective cohort study. 1,520 subjects who are first degree relatives of lung cancer patients at four public hospitals in Hong Kong will be screened. Intervention Detailed questionnaires and LDCT Thorax will be performed. The primary outcome measure is the number of lung cancers detected by this study. The screening-detection rate of lung cancer in first-degree relatives of lung cancer patients will be estimated.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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First degree relatives of lung cancer patients Age 50-75, men or women, smokers or non-smokers. Being first degree relatives (siblings, children and parents) of lung cancer subjects. Having no known lung cancer before. |
Diagnostic Test: Low dose CT thorax
A multi-detector row CT scanner with minimum section collimation of ≤1 mm and minimum number of data acquisition channels ≥ 16will be employed.
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Control group Non-lung cancer subjects who are not related any lung cancer patients |
Diagnostic Test: Low dose CT thorax
Control subjects will also proceed to CT thorax, and outcome measures be compared to subjects
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Outcome Measures
Primary Outcome Measures
- The rate of lung cancer detection in subjects with family history of lung cancer [An average of 2.5 years]
The number of screening-detected lung cancer among first degree relatives of lung cancer patients.
Secondary Outcome Measures
- The characteristics of screening detected lung cancer [An average of 2.5 years]
Stage distribution of lung cancer detected.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age 50-75, men or women, smokers or non-smokers
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Being first degree relatives (Siblings, children, and parents) of lung cancer subjects
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Having no known lung cancer before
Exclusion Criteria:
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Non-Chinese
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Mentally incompetent to give informed consent
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | University of Hong Kong | Hong Kong | Hong Kong | 0 |
Sponsors and Collaborators
- The University of Hong Kong
- The Queen Elizabeth Hospital
- Kwong Wah Hospital
- Hong Kong Sanatorium & Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
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- National Lung Screening Trial Research Team; Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, Gareen IF, Gatsonis C, Marcus PM, Sicks JD. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011 Aug 4;365(5):395-409. doi: 10.1056/NEJMoa1102873. Epub 2011 Jun 29.
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- HKU_UW_19_444