Lung Ultrasound in Procalcitonin- Guided Antibiotic Discontinuation in Ventilator Associated Pneumonia

Sponsor
Ain Shams University (Other)
Overall Status
Completed
CT.gov ID
NCT04563104
Collaborator
(none)
62
1
11
5.6

Study Details

Study Description

Brief Summary

Ventilator Associated pneumonia (VAP) is associated with longer ICU length of stay, prolonged mechanical ventilation, and increased use of antimicrobials, health-care cost and mortality . Acute respiratory infections (ARIs) comprise a large and heterogeneous group of infections, including bacterial infections, viral infections, and infections of other etiologies. Early initiation of adequate antibiotic therapy is the cornerstone in the treatment. However, overuse of antibiotics and prolonged duration of antibiotic therapy in patients with bacterial ARIs in the hospital and intensive care setting is associated with increased resistance for common bacteria, high costs, and adverse drug reactions.

Condition or Disease Intervention/Treatment Phase
  • Diagnostic Test: Lung Ultrasound

Study Design

Study Type:
Observational
Actual Enrollment :
62 participants
Observational Model:
Cohort
Time Perspective:
Prospective
Official Title:
Lung Ultrasound in Procalcitonin- Guided Antibiotic Discontinuation in Ventilator Associated Pneumonia
Actual Study Start Date :
Oct 1, 2020
Actual Primary Completion Date :
Aug 1, 2021
Actual Study Completion Date :
Sep 1, 2021

Outcome Measures

Primary Outcome Measures

  1. correlation between lung ultrasound and procalcitonin. [7 days]

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 80 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  • 18 years old or greater

  • Ventilator associated pneumonia (VAP) with positive sputum culture.

Exclusion Criteria:
  • pregnancy,

  • use of immunosuppressive agents except for steroids,

  • neutropenia (white blood cell count ≤1000/mL)

  • patients whose primary diagnosis was community acquired pneumonia and other source of infection.

Contacts and Locations

Locations

Site City State Country Postal Code
1 Ain Shams University Cairo Egypt

Sponsors and Collaborators

  • Ain Shams University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Mona Ammar, Assistant professor, Ain Shams University
ClinicalTrials.gov Identifier:
NCT04563104
Other Study ID Numbers:
  • R 49 / 2020
First Posted:
Sep 24, 2020
Last Update Posted:
Sep 28, 2021
Last Verified:
Sep 1, 2020
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
Yes
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of Sep 28, 2021