Early Evaluation of the Response of Large B Cell Non Hodgkin's Lymphoma to Chemotherapy by PET/CT

Sponsor

Université de Sherbrooke (Other)

Overall Status

Unknown status

CT.gov ID

NCT00256490

Collaborator

(none)

Enrollment

Location

Duration (Months)

1.7

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Patients affected with non-Hodgkin's large B-cell lymphoma are treated by chemotherapy. The evaluation of the response to this treatment is made by Positron Emission Tomography (PET/CT) in many centres where this technology is available. Presently PET scans and CT scans are being performed before treatment, after 4 cycles of chemotherapy and a few months after the end of treatment.

The goal of this study is to determine if it is possible to evaluate the efficiency of chemotherapy treatments after one cycle of treatment instead of waiting after 4 cycles, using a new scanner that combines PET and CT modalities. Data available from studies on these combined exams suggest that PET/CT helps to rapidly evaluate the response of the chemotherapy treatment. We also want to verify if some pathological characteristics measured from tumor cells will enable doctors to predict in advance the response to treatment.

Condition or Disease	Intervention/Treatment	Phase
Lymphoma, Large-Cell	Procedure: PET/CT 20 days after the first cycle of chemotherapy	N/A

Detailed Description

Participation in this study involves 4 PET/CT exams, which occur before the treatments start, after the first cycle of chemotherapy, after 4 cycles of chemotherapy and then 12 weeks after the end of the treatments. The only additional test performed in this study compared to the regular follow-up of patients that are not in this study is the PET/CT exam after the first cycle. Your participation in this study will not affect treatment since the results of the first PET/CT test will not be communicated. All other tests results will be available in the medical record.

Study Design

Study Type:

Interventional

Allocation:

Non-Randomized

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Diagnostic

Official Title:

Early Evaluation of the Response of Large B Cell Non Hodgkin's Lymphoma to Chemotherapy by Positron Emission Tomography Coupled With Computed Tomography (PET/CT)

Study Start Date :

Nov 1, 2005

Study Completion Date :

Nov 1, 2009

Outcome Measures

Primary Outcome Measures

Disease free survival at 2 years []

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 70 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Newly diagnosed large B cells non Hodgkin's lymphoma, CD20 positive
Chemotherapy treatments planned (R-CHOP) but not started

Exclusion Criteria:

Pregnancy (determined by urinary β-HCG and blood test)
Patients younger than 18 years
Unable to tolerate the procedure (30 minutes laying down on the back)
No chemotherapy treatment planned secondary to the patient's health performance
Previous lymphoma that has been treated with chemotherapy with the exception of stade I lymphoma treated only with radiotherapy.
All lymphoma other than large cell Non Hodgkin's lymphoma

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Centre Hospitalier Universitaire de Sherbrooke	Sherbrooke	Quebec	Canada	J1H 5N4

Sponsors and Collaborators

Université de Sherbrooke

Investigators

Principal Investigator: Eric Turcotte, MD, FRCPC, Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Principal Investigator: Francois Bénard, MD, FRCPC, Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Principal Investigator: Virginie Bruneau, MD, Centre de recherche du Centre hospitalier universitaire de Sherbrooke