Mechanism of Action of Transcranial Magnetic Stimulation
Study Details
Study Description
Brief Summary
This is an observational neuroimaging study assessing the effects of TMS on the brains of patients with unipolar depression.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Detailed Description
This project aims to use functional connectivity magnetic resonance imaging (fcMRI) to study patients with unipolar depression receiving TMS. Patients will be scanned before and after a full course of TMS and clinical measures for depression severity and memory will be obtained at the same times.The project has the following aims and hypothesis: (1) to determine the therapeutic antidepressant mechanism of action of TMS at the circuit level (2) to study the use of fcMRI as a state biomarker for depression (3) to study the use of fcMRI as a predictor of response for depression.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Other: Unipolar Depression Patients diagnosed with unipolar depression. |
Device: Transcranial Magnetic Stimulation
Transcranial magnetic stimulation uses a rapidly changing magnetic field to induce current in brain tissue non-invasively. It is common procedure in both clinical and research settings, and it has well established guidelines for safe an ethical use which maximize safety for all subjects.
Other Names:
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Outcome Measures
Primary Outcome Measures
- Changes in Functional Connectivity of Key Nodes in Depression [Through Treatment Completion, Average of 6 Weeks]
Measured by Magnetic Resonance Imaging
Eligibility Criteria
Criteria
Inclusion Criteria:
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Males and females between the ages of 18-80
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DSM-IV diagnosis of Depressive Episode
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Patients requiring TMS treatment as part of their psychiatric care
Exclusion Criteria:
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Comorbid DSM-IV primary diagnoses of schizoaffective disorder, schizophrenia or dementia.
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Substance use disorder (abuse or dependence) with active use within the last 3 months
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Severe or unstable medical illness.
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MRI contraindications as determined by MGH department of radiology.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Massachusetts General Hospital | Boston | Massachusetts | United States | 02129 |
Sponsors and Collaborators
- Massachusetts General Hospital
Investigators
- Principal Investigator: Joan Camprodon, MD, PhD, MPH, Massachusetts General Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2014P001835