MEDCCR: Medullary Colonic Carcinoma

Sponsor

University Hospital, Limoges (Other)

Overall Status

Completed

CT.gov ID

NCT05184153

Collaborator

(none)

Enrollment

Location

Actual Duration (Months)

0.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Retrospective cohort of 10 cases of colonic adenocarcinoma of medullary type, operated between 2000 and 2020 at the University Hospital of Limoges. Collection of relevant data for this rare entity. Subgroup analysis in search of prognostic factors. Comparison of the data from our cohort with those from the literature.

Condition or Disease	Intervention/Treatment	Phase
Medullary Carcinoma of Colon Prognostic Factors Survival Analysis

Detailed Description

Colorectal cancer (CRC) is the third most common cancer in the world after breast and prostate cancer (1). It is also the second most common cause of cancer death in France (2). Most CRCs are adenocarcinomas. However, there is a distinct subtype of adenocarcinoma of relatively recent recognition, called medullary carcinomas (MC). Its recent recognition as a distinct entity (3) has made it difficult to study the epidemiologic characteristics of this cancer, with little population-based data. The largest cohort studied in the literature is from a US sample of 74 patients seen between 1973 and 2006 (4). The main objective of this French retrospective study is to highlight some common features in this group of patients with medullary colorectal cancers, thus improving our knowledge of this cancer subtype and in particular its prognosis.

Medullary colorectal cancer is a type of cancer with a prognosis of its own, probably different from the most common histological entity, colorectal adenocarcinoma.

This is a retrospective study a cohort of 10 cases of colonic adenocarcinoma of medullary type, operated between 2000 and 2020 at the University Hospital of Limoges. A collection of relevant data was realised for the subgroup analysis in search of prognostic factors for this rare entity as well as a comparison of the data from this cohort with those from the literature.

Study Design

Study Type:

Observational

Actual Enrollment :

10 participants

Observational Model:

Cohort

Time Perspective:

Retrospective

Official Title:

Medullary Colonic Carcinoma

Actual Study Start Date :

Mar 3, 2020

Actual Primary Completion Date :

Dec 19, 2020

Actual Study Completion Date :

Sep 1, 2021

Outcome Measures

Primary Outcome Measures

Survival [Through study completion in April 2021]
Number of days between diagnosis and death

Secondary Outcome Measures

Progression [Through study completion in April 2021]
Number of days between first surgery and appearance of metastases

Eligibility Criteria

Criteria

Ages Eligible for Study:

N/A and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Pathological diagnosis of colorectal adenocarcinoma of medullary type between 2000 and 2020

Exclusion Criteria:

Absence of anatomopathological confirmation on the surgical specimen

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Service de Chirurgie Digestive et Endocrinienne du CHU de Limoges	Limoges		France	87045

Sponsors and Collaborators

University Hospital, Limoges

Investigators

Principal Investigator: Niki CHRISTOU, Dr, 0 33 5 55 05 67 30

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

University Hospital, Limoges

ClinicalTrials.gov Identifier:

NCT05184153

Other Study ID Numbers:

87RI20_0072 (MEDCCR)

First Posted:

Jan 11, 2022

Last Update Posted:

Jan 11, 2022

Last Verified:

Sep 1, 2021

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by University Hospital, Limoges

Medullary Carcinoma of Colon

prognostic factors

survival analysis

Additional relevant MeSH terms:

Carcinoma

Carcinoma, Medullary

Study Results

No Results Posted as of Jan 11, 2022