ESASP: Association Between a Biological Pattern of Dysregulation of the HPA Axis and Mental Disorders in Children Exposed to Early Life Stress
Study Details
Study Description
Brief Summary
The purpose of this study is to demonstrate an association between a biological pattern of dysregulation of the HPA axis and mental disorders in children exposed to early life stress.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Detailed Description
The purpose of this study is to demonstrate an association between a biological pattern of dysregulation of the HPA axis and mental disorders in children exposed to early life stress.
Cortisol secretion lead to define two groups : pathologic versus normal cortisol secretion.
Mental disorders is evaluate with Mini-Kids II (a mental health questionary) and lead to define two groups : mental disorders versus no mental disorders
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Other: study with just one arm All of participants are in this arm. Mini Kid II and CBCL score are administered between day 3 and 7. Moreover, salivary test will be remove to evaluate cortisol secretion, 4 time per day during 2 consecutive days. Psychologic aftercare will be propose if children have psychologic troubles (results of Mini Kid II) |
Behavioral: Mini Kid II
Mini Kid II (Mini International Neuropsychiatric Interview ) is a standardised, hetero mental health questionary for children, according to DSM IV. Mini Kid II will be administered to children between day 3 and 7 during the study.
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Outcome Measures
Primary Outcome Measures
- Mini Kid II : Mini International Neuropsychiatric Interview [Day 10 to the study]
Standardized questionary administered by a physician. There are 30 pages with 17 subjects like depression, maniac trouble, panic trouble, etc.
Secondary Outcome Measures
- CBCL score : Child Behaviour Check List [Day 10 to the study]
CBCL Score is a hetero scale administered by host family or caseworker. It is a scale 0 (no behavior troubles) to 124 (behavior troubles).
- BRIEF : Behavrioral Rating Inventory of Executive Function [Day 10 to the study]
Standardized questionary administered by by host family or caseworker between day 4 and 13 to the study. BRIEF questionary contains 2 themes (metacognition and Behavior regulation) with 85 items in total. Each item contains 3 answers : Never (0)/ Sometime(1)/ Always(2)
Eligibility Criteria
Criteria
Inclusion Criteria:
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Aged 8 to over 10 years
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To be entrust to ASE of Finistère in stable environment (the same place of residence since 6 months or more)
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French speaking
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Oral consent by children
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Informed and signed consent by tenured of parent authority
Exclusion Criteria:
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Don't want to participate
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To have chronic neurologic or endocrinal pathology or don't have access to verbal language.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | CHRU de Brest | Brest Cedex | France | 29609 |
Sponsors and Collaborators
- University Hospital, Brest
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 29BRC20.0056