The Effect of Mastiha Oil in Metabolic Syndrome
Study Details
Study Description
Brief Summary
Mastiha Oil is a 100% natural product of the Mediterranean, extracted from the resin of Mastiha. Over 90 compounds have been identified in Mastiha oil, with monoterpenes exhibiting favorable effects in regulating mechanisms of oxidative stress and inflammation. The aim of this study is to determine the effect of Mastiha oil in adults with Metabolic Syndrome. 90 participants will be allocated to two groups, (45 in intervention group and 45 in control group). Mastiha oil will be provided in the form of soft gel capsules to the intervention group, whereas the control group will not consume the capsules. Both groups will receive standard nutritional counselling. The intervention will last 3 months.
The effects of the intervention will be evaluated via clinical and laboratory markers.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Active Comparator: Intervention group Participants with metabolic disorders will be subjected to nutritional counsel and the intake of 1 soft gel capsule daily for a total of 3 months. |
Dietary Supplement: Mastiha oil
1 soft gel capsule of Mastiha oil every day for 3 months
|
No Intervention: Control group Participants with metabolic disorders will be subjected to nutritional counsel for a total of 3 months. |
Outcome Measures
Primary Outcome Measures
- Change in blood total cholesterol [3 months]
Levels will be evaluated pre and prost intervention in both control and intervention groups
- Change in insulin sensitivity [3 months]
Levels will be evaluated pre and prost intervention in both control and intervention groups
- Change in blood triglycerides [3 months]
Levels will be evaluated pre and prost intervention in both control and intervention groups
- Change in blood LDL [3 months]
Levels will be evaluated pre and prost intervention in both control and intervention groups
Secondary Outcome Measures
- Change in blood CRP [3 months]
Levels will be evaluated pre and prost intervention in both control and intervention groups
- Change in blood MPO [3 months]
Levels will be evaluated pre and prost intervention in both control and intervention groups
- Change in blood IL-6 [3 months]
Levels will be evaluated pre and prost intervention in both control and intervention groups
- Change in blood antioxidant potential [3 months]
Levels will be evaluated pre and prost intervention in both control and intervention groups
Eligibility Criteria
Criteria
Inclusion Criteria:
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30 years < Age < 75 years
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BMI > 25 kg/ m2
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Metabolic Syndrome
Exclusion Criteria:
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Hepatotoxic Medication
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Diabetes Mellitus
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Dysthyroidism, hypopituitarism, Cushing syndrome / disease
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Pregnancy, lactation
-
Psychiatric or mental disorder
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Any use of antioxidant-phytochemical rich supplement, vitamin D supplement, nti-, pre- or pro-biotics within 3 months pre-intervention
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Harokopio University | Athens | Attica | Greece | 17671 |
2 | Andriana Kaliora | Athens | Greece | 17671 |
Sponsors and Collaborators
- Harokopio University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Mastiha_oil_GR_477