177Lu-PSMA-617 Managed Access Program for mCRPC Patients

Sponsor
Advanced Accelerator Applications (Industry)
Overall Status
No longer available
CT.gov ID
NCT04825652
Collaborator
(none)

Study Details

Study Description

Brief Summary

The purpose of this Cohort Treatment Plan is to allow access to 177Lu-PSMA-617 for eligible patients diagnosed with metastatic castration-resistant prostate cancer (mCRPC). The patient's treating physician should follow the suggested treatment guidelines and comply with all local health authority regulations.

Detailed Description

PSMA-11 will be provided in certain cases where it may be required as a diagnostic imaging agent. PSMA-11 is used to confirm the presence of PSMA positive lesions in patients, which then makes them eligible for treatment with 177Lu-PSMA-617

Study Design

Study Type:
Expanded Access
Official Title:
Managed Access Program (MAP) Cohort Treatment Plan [CAAA617A12001M] to Provide Access to 177Lu-PSMA-617 for Patients With Metastatic Castration-resistant Prostate Cancer.

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    Male
    Inclusion Criteria:
    1. Patients must be ≥ 18 years of age.

    2. Patients must have progressive mCRPC. Documented progressive mCRPC will be based on at least 1 of the following criteria:

    • Rising PSA according to PCWG3 criteria (2 rising values above a baseline at a minimum of 1-week intervals) and PSA ≥2.0 ng/mL

    • Soft-tissue progression defined as per prostate cancer working group 3 (PCWG3)-modified RECIST v1.1

    • Progression of bone disease as per PCWG3 criteria

    1. Patients must have mCRPC with histological, pathological, and/or cytological confirmation of adenocarcinoma of the prostate.

    2. Patients must have ≥ 1 metastatic lesion that is present on baseline CT, MRI, or bone scan imaging.

    3. Patients must have prostate-specific membrane antigen (PSMA)- positive prostate cancer, as determined by PSMA-targeted PET / CT scan.

    4. Patients must have a castrate level of serum/plasma testosterone (< 50 ng/dL or < 1.7 nmol/L).

    5. Patients must have received at least one NAAD (such as enzalutamide and/or abiraterone).

    6. Patients must have been previously treated with at least 1, but no more than 2 previous taxane regimens. A taxane regimen is defined as a minimum exposure of 2 cycles of a taxane. If a patient has received only 1 taxane regimen, the patient is eligible if:

    1. The patient's physician deems him unsuitable to receive a second taxane regimen (e.g. frailty assessed by geriatric or health status evaluation, intolerance, etc.).
    1. Patients must have recovered to ≤ Grade 2 from all clinically significant toxicities related to prior therapies (i.e. prior chemotherapy, radiation, immunotherapy, etc.).

    2. Patients must have adequate organ function:

    3. Bone marrow reserve:

    • White blood cell (WBC) count ≥ 2.5 x 109/L (2.5 × 109/L is equivalent to 2.5 × 103/μL and 2.5 × K/μL and 2.5 × 103/cumm and 2500/μL) OR absolute neutrophil count (ANC) ≥ 1.5 × 109/L (1.5 × 109/L is equivalent to 1.5 × 103/μL and 1.5 × K/μL and 1.5 × 103/cumm and 1500/μL).

    • Platelets ≥ 100 × 109/L (100 × 109/L is equivalent to 100 × 103/μL and 100 × K/μL and 100 × 103/cumm and 100 000/μL).

    • Hemoglobin ≥ 9 g/dL (9 g/dL is equivalent to 90 g/L and 5.59 mmol/L).

    1. Hepatic:
    • Total bilirubin ≤ 1.5 × the institutional upper limit of normal (ULN). For patients with known Gilbert's Syndrome ≤ 3 × ULN is permitted.

    • Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 3.0 × ULN OR ≤ 5.0 × ULN for patients with liver metastases.

    1. Renal:
    • Serum/plasma creatinine ≤ 1.5 × ULN or creatinine clearance ≥ 50 mL/min.

    • Albumin > 3.0 g/dL (3.0 g/dL is equivalent to 30 g/L).

    Exclusion Criteria:
    1. History of hypersensitivity to any drugs or metabolites of similar chemical classes as Lu-PSMA-617.

    2. Other concurrent cytotoxic chemotherapy, immunotherapy, radioligand therapy, or investigational therapy.

    3. Transfusion for the sole purpose of making a subject eligible for study inclusion.

    4. Patients with a history of central nervous system (CNS) metastases must have received therapy (surgery, radiotherapy, gamma knife) and be neurologically stable, asymptomatic, and not receiving corticosteroids for the purposes of maintaining neurologic integrity.

    5. Patients with epidural disease, canal disease and prior cord involvement are eligible if those areas have been treated, are stable, and not neurologically impaired. For patients with parenchymal CNS metastasis (or a history of CNS metastasis), baseline and subsequent radiological imaging must include evaluation of the brain (MRI preferred or CT with contrast).

    6. Any pre-existing symptoms, or concurrent severe and/or uncontrolled medical conditions which could compromise safe participation in the MAP.

    7. Not able to understand and comply with treatment instructions and requirements.

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • Advanced Accelerator Applications

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Advanced Accelerator Applications
    ClinicalTrials.gov Identifier:
    NCT04825652
    Other Study ID Numbers:
    • CAAA617A12001M
    First Posted:
    Apr 1, 2021
    Last Update Posted:
    Apr 7, 2022
    Last Verified:
    Mar 1, 2022
    Keywords provided by Advanced Accelerator Applications
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Apr 7, 2022