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A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

Sponsor
National Cancer Institute (NCI) (NIH)
Overall Status
Recruiting
CT.gov ID
NCT02339571
Collaborator
(none)
600
Enrollment
652
Locations
2
Arms
85.7
Anticipated Duration (Months)
0.9
Patients Per Site
0
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This phase II/III trial studies the side effects of nivolumab and ipilimumab when given together with or without sargramostim and to see how well they work in treating patients with stage III-IV melanoma that cannot be removed by surgery (unresectable). Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Colony-stimulating factors, such as sargramostim, may increase the production of white blood cells. It is not yet known whether nivolumab and ipilimumab are more effective with or without sargramostim in treating patients with melanoma.

Condition or Disease Intervention/Treatment Phase
  • Biological: Ipilimumab
  • Biological: Nivolumab
  • Biological: Sargramostim
 Phase 2/Phase 3

Detailed Description

PRIMARY OBJECTIVE:
  1. To compare the overall survival (OS) of nivolumab/ipilimumab/sargramostim (GM-CSF) versus nivolumab/ipilimumab.
SECONDARY OBJECTIVES:

  1. To evaluate progression free survival (PFS) of patients treated with nivolumab/ipilimumab/GM-CSF versus nivolumab/ipilimumab.

  2. To assess for differences in tolerability, specifically the rate of grade III or higher adverse events, between nivolumab/ipilimumab/GM-CSF versus nivolumab/ipilimumab.

  3. To evaluate immune-related response rate (based on immune-related response criteria) and response rate (based on Response Evaluation Criteria in Solid Tumors [RECIST] criteria) and to compare them.

EXPLORATORY TOBACCO USE OBJECTIVES:

  1. To determine the effects of tobacco, operationalized as combustible tobacco (1a), other forms of tobacco (1b), and environmental tobacco exposure (ETS) (1c) on provider-reported cancer-treatment toxicity (adverse events [both clinical and hematologic] and dose modifications).

  2. To determine the effects of tobacco on patient-reported physical symptoms and psychological symptoms.

  3. To examine quitting behaviors and behavioral counseling/support and cessation medication utilization.

  4. To explore the effect of tobacco use and exposure on treatment duration, relative dose intensity, and therapeutic benefit.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM A: INDUCTION THERAPY: Patients receive nivolumab intravenously (IV) over 30 minutes on day 1, ipilimumab IV over 30 minutes on day 1, and sargramostim subcutaneously (SC) on days 1-14. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity.

MAINTENANCE THERAPY: Patients receive nivolumab and sargramostim as in induction therapy. Patients with partial response (PR), stable disease (SD), or complete response (CR) at 24 weeks may continue maintenance therapy for up to 2 years in the absence of disease progression or unacceptable toxicity.

ARM B: INDUCTION THERAPY: Patients receive nivolumab and ipilimumab as in Arm I. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity.

MAINTENANCE THERAPY: Patients receive nivolumab as in induction therapy. Patients with PR, SD, or CR at 24 weeks may continue maintenance therapy for up to 2 years in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
600 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
Randomized Phase II/III Study of Nivolumab Plus Ipilimumab Plus Sargramostim Versus Nivolumab Plus Ipilimumab in Patients With Unresectable Stage III or Stage IV Melanoma
Actual Study Start Date :
Sep 10, 2015
Anticipated Primary Completion Date :
Nov 1, 2022
Anticipated Study Completion Date :
Nov 1, 2022

Arms and Interventions

Arm Intervention/Treatment
Experimental: Arm A (nivolumab, ipilimumab, sargramostim)

INDUCTION THERAPY: Patients receive nivolumab IV over 30 minutes on day 1, ipilimumab IV over 30 minutes on day 1, and sargramostim SC on days 1-14. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. MAINTENANCE THERAPY: Patients receive nivolumab and sargramostim as in Induction therapy. Patients with PR, SC, or CR at 24 weeks may continue maintenance therapy for up to 2 years in the absence of disease progression or unacceptable toxicity.

Biological: Ipilimumab
Given IV
Other Names:
  • Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody
  • BMS-734016
  • Ipilimumab Biosimilar CS1002
  • MDX-010
  • MDX-CTLA4
  • Yervoy

    • Biological: Nivolumab
    Given IV
    Other Names:
  • BMS-936558
  • CMAB819
  • MDX-1106
  • NIVO
  • Nivolumab Biosimilar CMAB819
  • ONO-4538
  • Opdivo

    • Biological: Sargramostim
    Given SC
    Other Names:
  • 23-L-Leucinecolony-Stimulating Factor 2
  • DRG-0012
  • Leukine
  • Prokine
  • rhu GM-CFS
  • Sagramostim
  • Sargramostatin

    		•
    Experimental: Arm B (nivolumab, ipilimumab)

    INDUCTION THERAPY: Patients receive nivolumab and ipilimumab as in Arm I. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. MAINTENANCE THERAPY: Patients receive nivolumab as in Induction therapy. Patients with PR, SD, or CR at 24 weeks may continue maintenance therapy for up to 2 years in the absence of disease progression or unacceptable toxicity.

    Biological: Ipilimumab
    Given IV
    Other Names:
  • Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody
  • BMS-734016
  • Ipilimumab Biosimilar CS1002
  • MDX-010
  • MDX-CTLA4
  • Yervoy

    • Biological: Nivolumab
    Given IV
    Other Names:
  • BMS-936558
  • CMAB819
  • MDX-1106
  • NIVO
  • Nivolumab Biosimilar CMAB819
  • ONO-4538
  • Opdivo

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Overall survival [Time from randomization to death from any cause, assessed up to 5 years]

      Overall survival between the two arms will be compared using the stratified log-rank test. One-sided type I error rate of 0.2 will be used. Kaplan-Meier plot will be generated and two-sided p-values will be reported. This analysis will be summarized using the forest plots with hazard ratios and 95% confidence intervals. Cox multivariate models will be developed for overall survival.

    Secondary Outcome Measures

    1. Progression free survival [Time from randomization to disease progression or death (whichever occurs first), assessed up to 5 years]

      Evaluated based on international criteria proposed by the revised Response Evaluation Criteria in Solid Tumors guideline (version 1.1). This analysis will be summarized using the forest plots with hazard ratios and 95% confidence intervals. Cox multivariate models will be developed for progression free survival.

    2. Incidence of toxicities [Up to 90 days after the last study drug administration]

      Defined using the Common Terminology Criteria for Adverse Events version 4.0 criteria. Individual toxicity type adverse event and categorized adverse event data (by autoimmune disorders, endocrine, gastrointestinal, liver, nervous system, pancreas, psychiatric disorders, skin, thromboembolic disorders) will be summarized by grade and treatment arm. The percentages of patients experiencing the worst degree toxicities (highest grade event per adverse event type per patient) will be evaluated and the distribution of the worst degree toxicities will be compared among the treatment arms. The proportion of patients with worst degree toxicities with 3 or higher will be summarized and compared among the treatment arms.

    3. Immune response [Up to 5 years]

      Assessed using the utility of immune related response criteria. The immune related response criteria and the Response Evaluation Criteria in Solid Tumors-based clinical response data will be compared between the two treatment arms, using the Fisher's exact test. Two-sided p-values will be reported. Furthermore immune related response criteria data will be associated with the Response Evaluation Criteria in Solid Tumors-based clinical response. The Kappa statistics which measures the degree of agreement between the Response Evaluation Criteria in Solid Tumors-based response and immune related response criteria will be estimated. McNemar's test will be used to evaluate the agreement between immune related response criteria and Response Evaluation Criteria in Solid Tumors-based clinical response.

    4. Clinical response [Up to 5 years]

      Assessed using the utility of immune related response criteria. Standard response criteria (based on the Response Evaluation Criteria in Solid Tumors) will be applied to assess clinical response. The immune related response criteria and the Response Evaluation Criteria in Solid Tumors-based clinical response data will be compared between the two treatment arms, using the Fisher's exact test. Two-sided p-values will be reported. Furthermore immune related response criteria data will be associated with the Response Evaluation Criteria in Solid Tumors-based clinical response. The Kappa statistics which measures the degree of agreement between the Response Evaluation Criteria in Solid Tumors-based response and immune related response criteria will be estimated. McNemar's test will be used to evaluate the agreement between immune related response criteria and Response Evaluation Criteria in Solid Tumors-based clinical response.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • All patients must be >= 18 years of age

    • Eastern Cooperative Oncology Group (ECOG) performance status: 0 or 1

    • Patients must have known BRAF mutational status of tumor; wild-type (WT) or mutated, prior to randomization

    • Patients must have unresectable stage III or stage IV melanoma according to American Joint Committee on Cancer (AJCC) version (v)7; patients must have histological or cytological confirmation of melanoma that is metastatic or unresectable and clearly progressive

    • Patients must have measurable disease per RECIST 1.1 criteria; all sites of disease must be evaluated within 4 weeks prior to randomization

    • Patients may have had prior systemic therapy in the adjuvant setting (e.g. interferon, BRAF, or MEK agents). Patients may have had prior anti-CTLA-4 in the adjuvant setting, if at least one year from last dose of treatment has passed prior to beginning treatment. Patients may have had any prior programmed cell death (PD)-1/PD-ligand (PD-L)1 agent in the adjuvant setting, if at least one year from last dose of treatment has passed prior to beginning treatment

    • Patients must have discontinued chemotherapy, immunotherapy or other investigational agents used in the adjuvant setting >= 4 weeks prior to randomization and recovered from adverse events due to those agents; mitomycin and nitrosoureas must have been discontinued at least 6 weeks prior to entering the study; patients must have discontinued radiation therapy >= 2 weeks prior to entering the study and recovered from any adverse events associated with treatment; prior surgery must be >= 4 weeks from randomization and patients must be fully recovered from post-surgical complications

    • White blood count >= 3,000/uL (obtained within 4 weeks prior to randomization)

    • Absolute neutrophil count (ANC) >= 1,500/uL (obtained within 4 weeks prior to randomization)

    • Platelet count >= 100,000/uL (obtained within 4 weeks prior to randomization)

    • Hemoglobin >= 9 g/dL (obtained within 4 weeks prior to randomization)

    • Serum creatinine =< 1.5 x upper limit of normal (ULN) or serum creatinine clearance (CrCl) >= 40 ml/min (obtained within 4 weeks prior to randomization)

    • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x ULN (=< 5 x ULN for patients with documented liver metastases) (obtained within 4 weeks prior to randomization)

    • Alkaline phosphatase =< 2 x ULN (=< 5 x ULN for patients with known liver involvement and =< 7 x ULN for patients with known bone involvement) (obtained within 4 weeks prior to randomization)

    • Total bilirubin =< 1.5 x ULN except subjects with normal direct bilirubin or those with known Gilbert's syndrome (obtained within 4 weeks prior to randomization)

    • Serum lactate dehydrogenase (LDH) =< 10 X ULN (obtained within 4 weeks prior to randomization)

    • Patients with autoimmune hypothyroid disease or type I diabetes on replacement treatment are eligible

    Exclusion Criteria:

    • Patients must not be pregnant or breast-feeding due to use of cytotoxic immunotherapy and risk of teratogenic side effects; all patients of childbearing potential must have a blood test or urine study within 2 weeks prior to randomization to rule out pregnancy; a patient of childbearing potential is anyone, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

    • Patients must not conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse from the time of study registration and continuing (for patients of child bearing potential) for at least 5 months after the last dose of protocol treatment; patients of childbearing potential must also not donate eggs during this same time period

    • Patients may not have had any prior ipilimumab and/or anti-PD-1/PD-L1 agent in the metastatic setting

    • Patients must not receive any other investigational agents while on study or within four weeks prior to randomization

    • Patient must not have received any live vaccine within 30 days prior to randomization, while participating in the study, and for 4 weeks (28 days) after the last dose of protocol treatment; live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, bacillus Calmette-Guerin (BCG), and typhoid (oral) vaccine' patients are permitted to receive inactivated vaccines and any non-live vaccines including those for the seasonal influenza and coronavirus disease 19 (COVID-19) (Note: intranasal influenza vaccines, such as Flu-Mist are live attenuated vaccines and are not allowed); if possible, it is recommended to separate study drug administration from vaccine administration by about a week (primarily, in order to minimize an overlap of adverse events)

    • Patients are ineligible if they have any currently active central nervous system (CNS) metastases; patients who have treated brain metastases (with either surgical resection or stereotactic radiosurgery) that have been stable on head magnetic resonance imaging (MRI) or contrast computed tomography (CT) scan for at least 4 weeks following treatment and within 4 weeks prior to randomization are eligible; patients must not have taken any steroids =< 14 days prior to randomization for the purpose of managing their brain metastases; patients with only whole brain irradiation for treatment of CNS metastases will be ineligible

    • Patients must not have other current malignancies, other than basal cell skin cancer, squamous cell skin cancer, in situ cervical cancer, ductal or lobular carcinoma in situ of the breast; patients with other malignancies are eligible if they have been continuously disease-free for > 3 years prior to the time of randomization

    • Patients must not have any serious or unstable pre-existing medical conditions (aside from malignancy exceptions specified above), including but not limited to, ongoing or active infection requiring parenteral antibiotics on day 1, history of bleeding diathesis or need for concurrent anticoagulation (international normalized ratio [INR] =< 1.5 and partial thromboplastin time [PTT] within 1.1 x ULN), or psychiatric illness/social situations that would limit compliance with study requirements, interfere with subject's safety, or obtaining informed consent

    • Patients with human immunodeficiency virus (HIV) infection are ineligible; due to the mechanism of action of ipilimumab and GM-CSF, activity and side effects in an immune compromised patient are unknown

    • Patients with evidence of active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection are not eligible; patients with cleared HBV and HCV (0 viral load) infection will be allowed

    • Patients must not have autoimmune disorders or conditions of immunosuppression that require current ongoing treatment with systemic corticosteroids (or other systemic immunosuppressants), including oral steroids (e.g., prednisone, dexamethasone) or continuous use of topical steroid creams or ointments or ophthalmologic steroids; a history of occasional (but not continuous) use of steroid inhalers is allowed; replacement doses of steroids for patients with adrenal insufficiency are allowed; patients who discontinue use of these classes of medication for at least 2 weeks prior to randomization are eligible if, in the judgment of the treating physician investigator, the patient is not likely to require resumption of treatment with these classes of drugs during the study

    • Exclusion from this study also includes patients with a history of symptomatic autoimmune disease (e.g., rheumatoid arthritis, systemic progressive sclerosis [scleroderma], systemic lupus erythematosus, Sjogren's syndrome, autoimmune vasculitis [e.g., Wegener's granulomatosis]); motor neuropathy considered of autoimmune origin (e.g., Guillain-Barre syndrome and myasthenia gravis); other CNS autoimmune disease (e.g., multiple sclerosis)

    • Patients must not have a history of inflammatory bowel disease or diverticulitis (history of diverticulosis is allowed)

    • Patients must not have other significant medical, surgical, or psychiatric conditions or require any medication or treatment that in the opinion of the investigator may interfere with compliance, make the administration of the study drugs hazardous or obscure the interpretation of adverse events (AEs), such as a condition associated with frequent diarrhea; patients must not have an active infection requiring current treatment with parenteral antibiotics

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 University of Alabama at Birmingham Cancer Center Birmingham Alabama United States 35233
    2 Kingman Regional Medical Center Kingman Arizona United States 86401
    3 John L McClellan Memorial Veterans Hospital Little Rock Arkansas United States 72205
    4 Kaiser Permanente-Anaheim Anaheim California United States 92806
    5 PCR Oncology Arroyo Grande California United States 93420
    6 Sutter Auburn Faith Hospital Auburn California United States 95602
    7 Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn California United States 95603
    8 Kaiser Permanente-Baldwin Park Baldwin Park California United States 91706
    9 Kaiser Permanente-Bellflower Bellflower California United States 90706
    10 Alta Bates Summit Medical Center-Herrick Campus Berkeley California United States 94704
    11 Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park California United States 95682
    12 Eden Hospital Medical Center Castro Valley California United States 94546
    13 Sutter Davis Hospital Davis California United States 95616
    14 City of Hope Comprehensive Cancer Center Duarte California United States 91010
    15 Kaiser Permanente Dublin Dublin California United States 94568
    16 Kaiser Permanente-Fontana Fontana California United States 92335
    17 Palo Alto Medical Foundation-Fremont Fremont California United States 94538
    18 Kaiser Permanente-Fresno Fresno California United States 93720
    19 Kaiser Permanente - Harbor City Harbor City California United States 90710
    20 Kaiser Permanente-Irvine Irvine California United States 92618
    21 Kaiser Permanente Los Angeles Medical Center Los Angeles California United States 90027
    22 Kaiser Permanente West Los Angeles Los Angeles California United States 90034
    23 Memorial Medical Center Modesto California United States 95355
    24 Kaiser Permanente-Modesto Modesto California United States 95356
    25 Palo Alto Medical Foundation-Camino Division Mountain View California United States 94040
    26 Palo Alto Medical Foundation-Gynecologic Oncology Mountain View California United States 94040
    27 Sutter Cancer Research Consortium Novato California United States 94945
    28 Kaiser Permanente-Oakland Oakland California United States 94611
    29 Kaiser Permanente-Ontario Ontario California United States 91761
    30 Saint Joseph Hospital - Orange Orange California United States 92868
    31 UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California United States 92868
    32 Palo Alto Medical Foundation Health Care Palo Alto California United States 94301
    33 Stanford Cancer Institute Palo Alto Palo Alto California United States 94304
    34 Kaiser Permanente - Panorama City Panorama City California United States 91402
    35 Kaiser Permanente-Richmond Richmond California United States 94801
    36 Kaiser Permanente-Riverside Riverside California United States 92505
    37 Kaiser Permanente-Roseville Roseville California United States 95661
    38 Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville California United States 95661
    39 Sutter Roseville Medical Center Roseville California United States 95661
    40 Kaiser Permanente Downtown Commons Sacramento California United States 95814
    41 Sutter Medical Center Sacramento Sacramento California United States 95816
    42 Kaiser Permanente-South Sacramento Sacramento California United States 95823
    43 Kaiser Permanente - Sacramento Sacramento California United States 95825
    44 Kaiser Permanente-San Diego Mission San Diego California United States 92108
    45 Kaiser Permanente-San Diego Zion San Diego California United States 92120
    46 Naval Medical Center -San Diego San Diego California United States 92134
    47 California Pacific Medical Center-Pacific Campus San Francisco California United States 94115
    48 Kaiser Permanente-Santa Teresa-San Jose San Jose California United States 95119
    49 Kaiser Permanente San Leandro San Leandro California United States 94577
    50 Kaiser Permanente-San Marcos San Marcos California United States 92078
    51 Mills Health Center San Mateo California United States 94401
    52 Kaiser Permanente-San Rafael San Rafael California United States 94903
    53 Kaiser San Rafael-Gallinas San Rafael California United States 94903
    54 Kaiser Permanente Medical Center - Santa Clara Santa Clara California United States 95051
    55 Palo Alto Medical Foundation-Santa Cruz Santa Cruz California United States 95065
    56 Sutter Pacific Medical Foundation Santa Rosa California United States 95403
    57 Kaiser Permanente-Stockton Stockton California United States 95210
    58 Palo Alto Medical Foundation-Sunnyvale Sunnyvale California United States 94086
    59 City of Hope Upland Upland California United States 91786
    60 Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville California United States 95687
    61 Kaiser Permanente Medical Center-Vacaville Vacaville California United States 95688
    62 Kaiser Permanente-Vallejo Vallejo California United States 94589
    63 Sutter Solano Medical Center/Cancer Center Vallejo California United States 94589
    64 Kaiser Permanente-Walnut Creek Walnut Creek California United States 94596
    65 Kaiser Permanente-Woodland Hills Woodland Hills California United States 91367
    66 The Medical Center of Aurora Aurora Colorado United States 80012
    67 Boulder Community Hospital Boulder Colorado United States 80301
    68 Penrose-Saint Francis Healthcare Colorado Springs Colorado United States 80907
    69 Kaiser Permanente-Franklin Denver Colorado United States 80205
    70 Porter Adventist Hospital Denver Colorado United States 80210
    71 Presbyterian - Saint Lukes Medical Center - Health One Denver Colorado United States 80218
    72 SCL Health Saint Joseph Hospital Denver Colorado United States 80218
    73 Rose Medical Center Denver Colorado United States 80220
    74 Mercy Medical Center Durango Colorado United States 81301
    75 Southwest Oncology PC Durango Colorado United States 81301
    76 Mountain Blue Cancer Care Center - Swedish Englewood Colorado United States 80113
    77 Rocky Mountain Cancer Centers - Swedish Englewood Colorado United States 80113
    78 Swedish Medical Center Englewood Colorado United States 80113
    79 The Melanoma and Skin Cancer Institute Englewood Colorado United States 80113
    80 North Colorado Medical Center Greeley Colorado United States 80631
    81 Kaiser Permanente-Rock Creek Lafayette Colorado United States 80026
    82 Saint Anthony Hospital Lakewood Colorado United States 80228
    83 Kaiser Permanente-Lone Tree Lone Tree Colorado United States 80124
    84 Sky Ridge Medical Center Lone Tree Colorado United States 80124
    85 Longmont United Hospital Longmont Colorado United States 80501
    86 McKee Medical Center Loveland Colorado United States 80539
    87 Saint Mary Corwin Medical Center Pueblo Colorado United States 81004
    88 SCL Health Lutheran Medical Center Wheat Ridge Colorado United States 80033
    89 Smilow Cancer Hospital Care Center - Guiford Guilford Connecticut United States 06437
    90 Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut United States 06105
    91 Yale University New Haven Connecticut United States 06520
    92 MedStar Georgetown University Hospital Washington District of Columbia United States 20007
    93 MedStar Washington Hospital Center Washington District of Columbia United States 20010
    94 UM Sylvester Comprehensive Cancer Center at Aventura Aventura Florida United States 33180
    95 UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida United States 33146
    96 UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida United States 33442
    97 Holy Cross Hospital Fort Lauderdale Florida United States 33308
    98 University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida United States 33136
    99 UM Sylvester Comprehensive Cancer Center at Kendall Miami Florida United States 33176
    100 UM Sylvester Comprehensive Cancer Center at Plantation Plantation Florida United States 33324
    101 Moffitt Cancer Center-International Plaza Tampa Florida United States 33607
    102 Moffitt Cancer Center - McKinley Campus Tampa Florida United States 33612
    103 Moffitt Cancer Center Tampa Florida United States 33612
    104 University Cancer and Blood Center LLC Athens Georgia United States 30607
    105 Emory University Hospital/Winship Cancer Institute Atlanta Georgia United States 30322
    106 Northside Hospital Atlanta Georgia United States 30342
    107 Augusta University Medical Center Augusta Georgia United States 30912
    108 Northside Hospital-Forsyth Cumming Georgia United States 30041
    109 Dekalb Medical Center Decatur Georgia United States 30033
    110 Northside Hospital - Duluth Duluth Georgia United States 30096
    111 Northside Hospital - Gwinnett Lawrenceville Georgia United States 30046
    112 Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah Georgia United States 31405
    113 Summit Cancer Care-Candler Savannah Georgia United States 31405
    114 Hawaii Cancer Care - Savio 'Aiea Hawaii United States 96701
    115 Pali Momi Medical Center 'Aiea Hawaii United States 96701
    116 Queen's Cancer Center - Pearlridge 'Aiea Hawaii United States 96701
    117 Straub Pearlridge Clinic 'Aiea Hawaii United States 96701
    118 The Cancer Center of Hawaii-Pali Momi 'Aiea Hawaii United States 96701
    119 The Queen's Medical Center - West Oahu 'Ewa Beach Hawaii United States 96706
    120 Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii United States 96813
    121 Island Urology Honolulu Hawaii United States 96813
    122 Queen's Cancer Cenrer - POB I Honolulu Hawaii United States 96813
    123 Queen's Medical Center Honolulu Hawaii United States 96813
    124 Straub Clinic and Hospital Honolulu Hawaii United States 96813
    125 University of Hawaii Cancer Center Honolulu Hawaii United States 96813
    126 Hawaii Cancer Care Inc-Liliha Honolulu Hawaii United States 96817
    127 Hawaii Diagnostic Radiology Services LLC Honolulu Hawaii United States 96817
    128 Kuakini Medical Center Honolulu Hawaii United States 96817
    129 Queen's Cancer Center - Kuakini Honolulu Hawaii United States 96817
    130 The Cancer Center of Hawaii-Liliha Honolulu Hawaii United States 96817
    131 Kaiser Permanente Moanalua Medical Center Honolulu Hawaii United States 96819
    132 Kapiolani Medical Center for Women and Children Honolulu Hawaii United States 96826
    133 Straub Medical Center - Kahului Clinic Kahului Hawaii United States 96732
    134 Castle Medical Center Kailua Hawaii United States 96734
    135 Wilcox Memorial Hospital and Kauai Medical Clinic Lihue Hawaii United States 96766
    136 Saint Alphonsus Cancer Care Center-Boise Boise Idaho United States 83706
    137 Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho United States 83605
    138 Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho United States 83814
    139 Walter Knox Memorial Hospital Emmett Idaho United States 83617
    140 Idaho Urologic Institute-Meridian Meridian Idaho United States 83642
    141 Saint Alphonsus Medical Center-Nampa Nampa Idaho United States 83686
    142 Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho United States 83854
    143 Kootenai Cancer Clinic Sandpoint Idaho United States 83864
    144 Rush - Copley Medical Center Aurora Illinois United States 60504
    145 Saint Joseph Medical Center Bloomington Illinois United States 61701
    146 Illinois CancerCare-Bloomington Bloomington Illinois United States 61704
    147 Illinois CancerCare-Canton Canton Illinois United States 61520
    148 Memorial Hospital of Carbondale Carbondale Illinois United States 62902
    149 SIH Cancer Institute Carterville Illinois United States 62918
    150 Illinois CancerCare-Carthage Carthage Illinois United States 62321
    151 Centralia Oncology Clinic Centralia Illinois United States 62801
    152 Northwestern University Chicago Illinois United States 60611
    153 Carle on Vermilion Danville Illinois United States 61832
    154 Cancer Care Specialists of Illinois - Decatur Decatur Illinois United States 62526
    155 Decatur Memorial Hospital Decatur Illinois United States 62526
    156 Illinois CancerCare-Dixon Dixon Illinois United States 61021
    157 Carle Physician Group-Effingham Effingham Illinois United States 62401
    158 Crossroads Cancer Center Effingham Illinois United States 62401
    159 Illinois CancerCare-Eureka Eureka Illinois United States 61530
    160 NorthShore University HealthSystem-Evanston Hospital Evanston Illinois United States 60201
    161 Illinois CancerCare-Galesburg Galesburg Illinois United States 61401
    162 Western Illinois Cancer Treatment Center Galesburg Illinois United States 61401
    163 NorthShore University HealthSystem-Glenbrook Hospital Glenview Illinois United States 60026
    164 NorthShore University HealthSystem-Highland Park Hospital Highland Park Illinois United States 60035
    165 Illinois CancerCare-Kewanee Clinic Kewanee Illinois United States 61443
    166 Illinois CancerCare-Macomb Macomb Illinois United States 61455
    167 Carle Physician Group-Mattoon/Charleston Mattoon Illinois United States 61938
    168 Cancer Care Center of O'Fallon O'Fallon Illinois United States 62269
    169 Illinois CancerCare-Ottawa Clinic Ottawa Illinois United States 61350
    170 Illinois CancerCare-Pekin Pekin Illinois United States 61554
    171 OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin Illinois United States 61554
    172 Illinois CancerCare-Peoria Peoria Illinois United States 61615
    173 OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria Illinois United States 61615
    174 Methodist Medical Center of Illinois Peoria Illinois United States 61636
    175 OSF Saint Francis Medical Center Peoria Illinois United States 61637
    176 Illinois CancerCare-Peru Peru Illinois United States 61354
    177 Valley Radiation Oncology Peru Illinois United States 61354
    178 Illinois CancerCare-Princeton Princeton Illinois United States 61356
    179 Southern Illinois University School of Medicine Springfield Illinois United States 62702
    180 Springfield Clinic Springfield Illinois United States 62702
    181 Memorial Medical Center Springfield Illinois United States 62781
    182 Southwest Illinois Health Services LLP Swansea Illinois United States 62226
    183 Carle Cancer Center Urbana Illinois United States 61801
    184 The Carle Foundation Hospital Urbana Illinois United States 61801
    185 Illinois CancerCare - Washington Washington Illinois United States 61571
    186 Rush-Copley Healthcare Center Yorkville Illinois United States 60560
    187 Deaconess Clinic Downtown Evansville Indiana United States 47713
    188 Indiana University/Melvin and Bren Simon Cancer Center Indianapolis Indiana United States 46202
    189 Franciscan Health Indianapolis Indianapolis Indiana United States 46237
    190 Franciscan Saint Anthony Health-Michigan City Michigan City Indiana United States 46360
    191 Woodland Cancer Care Center Michigan City Indiana United States 46360
    192 Franciscan Health Mooresville Mooresville Indiana United States 46158
    193 Chancellor Center for Oncology Newburgh Indiana United States 47630
    194 Reid Health Richmond Indiana United States 47374
    195 Mary Greeley Medical Center Ames Iowa United States 50010
    196 McFarland Clinic PC - Ames Ames Iowa United States 50010
    197 McFarland Clinic PC-Boone Boone Iowa United States 50036
    198 McFarland Clinic PC-Trinity Cancer Center Fort Dodge Iowa United States 50501
    199 McFarland Clinic PC-Jefferson Jefferson Iowa United States 50129
    200 McFarland Clinic PC-Marshalltown Marshalltown Iowa United States 50158
    201 Siouxland Regional Cancer Center Sioux City Iowa United States 51101
    202 Cancer Center of Kansas - Chanute Chanute Kansas United States 66720
    203 Cancer Center of Kansas - Dodge City Dodge City Kansas United States 67801
    204 Cancer Center of Kansas - El Dorado El Dorado Kansas United States 67042
    205 Cancer Center of Kansas - Fort Scott Fort Scott Kansas United States 66701
    206 Cancer Center of Kansas-Independence Independence Kansas United States 67301
    207 Cancer Center of Kansas-Kingman Kingman Kansas United States 67068
    208 Lawrence Memorial Hospital Lawrence Kansas United States 66044
    209 Cancer Center of Kansas-Liberal Liberal Kansas United States 67905
    210 Cancer Center of Kansas-Manhattan Manhattan Kansas United States 66502
    211 Cancer Center of Kansas - McPherson McPherson Kansas United States 67460
    212 Cancer Center of Kansas - Newton Newton Kansas United States 67114
    213 Cancer Center of Kansas - Parsons Parsons Kansas United States 67357
    214 Cancer Center of Kansas - Pratt Pratt Kansas United States 67124
    215 Cancer Center of Kansas - Salina Salina Kansas United States 67401
    216 Cotton O'Neil Cancer Center / Stormont Vail Health Topeka Kansas United States 66606
    217 Cancer Center of Kansas - Wellington Wellington Kansas United States 67152
    218 Associates In Womens Health Wichita Kansas United States 67208
    219 Cancer Center of Kansas-Wichita Medical Arts Tower Wichita Kansas United States 67208
    220 Ascension Via Christi Hospitals Wichita Wichita Kansas United States 67214
    221 Cancer Center of Kansas - Wichita Wichita Kansas United States 67214
    222 Cancer Center of Kansas - Winfield Winfield Kansas United States 67156
    223 Oncology Hematology Care Inc-Crestview Crestview Hills Kentucky United States 41017
    224 The James Graham Brown Cancer Center at University of Louisville Louisville Kentucky United States 40202
    225 LSU Health Baton Rouge-North Clinic Baton Rouge Louisiana United States 70805
    226 Our Lady of The Lake Baton Rouge Louisiana United States 70808
    227 Louisiana Hematology Oncology Associates LLC Baton Rouge Louisiana United States 70809
    228 Mary Bird Perkins Cancer Center Baton Rouge Louisiana United States 70809
    229 Ochsner Health Center-Summa Baton Rouge Louisiana United States 70809
    230 Our Lady of the Lake Physicians Group - Medical Oncology Baton Rouge Louisiana United States 70809
    231 Medical Center of Baton Rouge Baton Rouge Louisiana United States 70816
    232 Ochsner High Grove Baton Rouge Louisiana United States 70836
    233 Mary Bird Perkins Cancer Center - Covington Covington Louisiana United States 70433
    234 Northshore Oncology Associates-Covington Covington Louisiana United States 70433
    235 Mary Bird Perkins Cancer Center - Houma Houma Louisiana United States 70360
    236 Oncology Center of The South Incorporated Houma Louisiana United States 70360
    237 Ochsner Medical Center Kenner Kenner Louisiana United States 70065
    238 Ochsner LSU Health Monroe Medical Center Monroe Louisiana United States 71202
    239 Louisiana State University Health Science Center New Orleans Louisiana United States 70112
    240 University Medical Center New Orleans New Orleans Louisiana United States 70112
    241 Ochsner Medical Center Jefferson New Orleans Louisiana United States 70121
    242 LSU Health Sciences Center at Shreveport Shreveport Louisiana United States 71103
    243 CHRISTUS Highland Medical Center Shreveport Louisiana United States 71105
    244 Eastern Maine Medical Center Bangor Maine United States 04401
    245 Lafayette Family Cancer Center-EMMC Brewer Maine United States 04412
    246 Maine Center for Cancer Medicine-Kennebunk Kennebunk Maine United States 04043
    247 Maine Center for Cancer Medicine-Scarborough Scarborough Maine United States 04074
    248 Greater Baltimore Medical Center Baltimore Maryland United States 21204
    249 Sinai Hospital of Baltimore Baltimore Maryland United States 21215
    250 Saint Agnes Hospital Baltimore Maryland United States 21229
    251 MedStar Franklin Square Medical Center/Weinberg Cancer Institute Baltimore Maryland United States 21237
    252 Western Maryland Regional Medical Center Cumberland Maryland United States 21502
    253 Northwest Hospital Center Randallstown Maryland United States 21133
    254 Massachusetts General Hospital Cancer Center Boston Massachusetts United States 02114
    255 Beth Israel Deaconess Medical Center Boston Massachusetts United States 02215
    256 Dana-Farber Cancer Institute Boston Massachusetts United States 02215
    257 Baystate Medical Center Springfield Massachusetts United States 01199
    258 UMass Memorial Medical Center - University Campus Worcester Massachusetts United States 01655
    259 Hickman Cancer Center Adrian Michigan United States 49221
    260 Saint Joseph Mercy Hospital Ann Arbor Michigan United States 48106
    261 Bronson Battle Creek Battle Creek Michigan United States 49017
    262 Saint Joseph Mercy Brighton Brighton Michigan United States 48114
    263 Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan United States 48114
    264 Saint Joseph Mercy Canton Canton Michigan United States 48188
    265 Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan United States 48188
    266 Caro Cancer Center Caro Michigan United States 48723
    267 Saint Joseph Mercy Chelsea Chelsea Michigan United States 48118
    268 Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan United States 48118
    269 Hematology Oncology Consultants-Clarkston Clarkston Michigan United States 48346
    270 Newland Medical Associates-Clarkston Clarkston Michigan United States 48346
    271 Beaumont Hospital - Dearborn Dearborn Michigan United States 48124
    272 Ascension Saint John Hospital Detroit Michigan United States 48236
    273 Great Lakes Cancer Management Specialists-Doctors Park East China Township Michigan United States 48054
    274 Genesee Cancer and Blood Disease Treatment Center Flint Michigan United States 48503
    275 Genesee Hematology Oncology PC Flint Michigan United States 48503
    276 Genesys Hurley Cancer Institute Flint Michigan United States 48503
    277 Hurley Medical Center Flint Michigan United States 48503
    278 Mercy Health Saint Mary's Grand Rapids Michigan United States 49503
    279 Spectrum Health at Butterworth Campus Grand Rapids Michigan United States 49503
    280 Academic Hematology Oncology Specialists Grosse Pointe Woods Michigan United States 48236
    281 Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Grosse Pointe Woods Michigan United States 48236
    282 Michigan Breast Specialists-Grosse Pointe Woods Grosse Pointe Woods Michigan United States 48236
    283 Allegiance Health Jackson Michigan United States 49201
    284 Bronson Methodist Hospital Kalamazoo Michigan United States 49007
    285 West Michigan Cancer Center Kalamazoo Michigan United States 49007
    286 Ascension Borgess Cancer Center Kalamazoo Michigan United States 49009
    287 Borgess Medical Center Kalamazoo Michigan United States 49048
    288 Sparrow Hospital Lansing Michigan United States 48912
    289 Hope Cancer Clinic Livonia Michigan United States 48154
    290 Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan United States 48154
    291 Great Lakes Cancer Management Specialists-Macomb Medical Campus Macomb Michigan United States 48044
    292 Michigan Breast Specialists-Macomb Township Macomb Michigan United States 48044
    293 Saint Mary's Oncology/Hematology Associates of Marlette Marlette Michigan United States 48453
    294 Toledo Clinic Cancer Centers-Monroe Monroe Michigan United States 48162
    295 Mercy Health Mercy Campus Muskegon Michigan United States 49444
    296 Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan United States 49444
    297 21st Century Oncology-Pontiac Pontiac Michigan United States 48341
    298 Hope Cancer Center Pontiac Michigan United States 48341
    299 Newland Medical Associates-Pontiac Pontiac Michigan United States 48341
    300 Saint Joseph Mercy Oakland Pontiac Michigan United States 48341
    301 Spectrum Health Reed City Hospital Reed City Michigan United States 49677
    302 Great Lakes Cancer Management Specialists-Rochester Hills Rochester Hills Michigan United States 48309
    303 William Beaumont Hospital-Royal Oak Royal Oak Michigan United States 48073
    304 Ascension Saint Mary's Hospital Saginaw Michigan United States 48601
    305 Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan United States 48604
    306 Bhadresh Nayak MD PC-Sterling Heights Sterling Heights Michigan United States 48312
    307 Ascension Saint Joseph Hospital Tawas City Michigan United States 48764
    308 Munson Medical Center Traverse City Michigan United States 49684
    309 William Beaumont Hospital - Troy Troy Michigan United States 48085
    310 Advanced Breast Care Center PLLC Warren Michigan United States 48088
    311 Great Lakes Cancer Management Specialists-Macomb Professional Building Warren Michigan United States 48093
    312 Macomb Hematology Oncology PC Warren Michigan United States 48093
    313 Michigan Breast Specialists-Warren Warren Michigan United States 48093
    314 Saint John Macomb-Oakland Hospital Warren Michigan United States 48093
    315 Saint Mary's Oncology/Hematology Associates of West Branch West Branch Michigan United States 48661
    316 Metro Health Hospital Wyoming Michigan United States 49519
    317 Huron Gastroenterology PC Ypsilanti Michigan United States 48106
    318 Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan United States 48197
    319 Riverwood Healthcare Center Aitkin Minnesota United States 56431
    320 Essentia Health - Baxter Clinic Baxter Minnesota United States 56425
    321 Sanford Joe Lueken Cancer Center Bemidji Minnesota United States 56601
    322 Essentia Health Saint Joseph's Medical Center Brainerd Minnesota United States 56401
    323 Fairview Ridges Hospital Burnsville Minnesota United States 55337
    324 Minnesota Oncology - Burnsville Burnsville Minnesota United States 55337
    325 Cambridge Medical Center Cambridge Minnesota United States 55008
    326 Mercy Hospital Coon Rapids Minnesota United States 55433
    327 Essentia Health - Deer River Clinic Deer River Minnesota United States 56636
    328 Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes Minnesota United States 56501
    329 Essentia Health Cancer Center Duluth Minnesota United States 55805
    330 Essentia Health Saint Mary's Medical Center Duluth Minnesota United States 55805
    331 Miller-Dwan Hospital Duluth Minnesota United States 55805
    332 Fairview Southdale Hospital Edina Minnesota United States 55435
    333 Essentia Health - Ely Clinic Ely Minnesota United States 55731
    334 Lake Region Healthcare Corporation-Cancer Care Fergus Falls Minnesota United States 56537
    335 Essentia Health - Fosston Fosston Minnesota United States 56542
    336 Unity Hospital Fridley Minnesota United States 55432
    337 Essentia Health Hibbing Clinic Hibbing Minnesota United States 55746
    338 Essentia Health - International Falls Clinic International Falls Minnesota United States 56649
    339 Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota United States 55369
    340 Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota United States 55109
    341 Saint John's Hospital - Healtheast Maplewood Minnesota United States 55109
    342 Abbott-Northwestern Hospital Minneapolis Minnesota United States 55407
    343 Hennepin County Medical Center Minneapolis Minnesota United States 55415
    344 Health Partners Inc Minneapolis Minnesota United States 55454
    345 Monticello Cancer Center Monticello Minnesota United States 55362
    346 Essentia Health - Moose Lake Clinic Moose Lake Minnesota United States 55767
    347 New Ulm Medical Center New Ulm Minnesota United States 56073
    348 Essentia Health - Park Rapids Park Rapids Minnesota United States 56470
    349 Fairview Northland Medical Center Princeton Minnesota United States 55371
    350 North Memorial Medical Health Center Robbinsdale Minnesota United States 55422
    351 Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota United States 55416
    352 Regions Hospital Saint Paul Minnesota United States 55101
    353 United Hospital Saint Paul Minnesota United States 55102
    354 Essentia Health Sandstone Sandstone Minnesota United States 55072
    355 Saint Francis Regional Medical Center Shakopee Minnesota United States 55379
    356 Lakeview Hospital Stillwater Minnesota United States 55082
    357 Sanford Thief River Falls Medical Center Thief River Falls Minnesota United States 56701
    358 Essentia Health Virginia Clinic Virginia Minnesota United States 55792
    359 Ridgeview Medical Center Waconia Minnesota United States 55387
    360 Rice Memorial Hospital Willmar Minnesota United States 56201
    361 Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota United States 55125
    362 Sanford Cancer Center Worthington Worthington Minnesota United States 56187
    363 Fairview Lakes Medical Center Wyoming Minnesota United States 55092
    364 Parkland Health Center-Bonne Terre Bonne Terre Missouri United States 63628
    365 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
    366 Southeast Cancer Center Cape Girardeau Missouri United States 63703
    367 Parkland Health Center - Farmington Farmington Missouri United States 63640
    368 Capital Region Southwest Campus Jefferson City Missouri United States 65109
    369 Heartland Regional Medical Center Saint Joseph Missouri United States 64506
    370 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
    371 Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri United States 63670
    372 Mercy Hospital Springfield Springfield Missouri United States 65804
    373 CoxHealth South Hospital Springfield Missouri United States 65807
    374 Missouri Baptist Sullivan Hospital Sullivan Missouri United States 63080
    375 Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri United States 63127
    376 Community Hospital of Anaconda Anaconda Montana United States 59711
    377 Billings Clinic Cancer Center Billings Montana United States 59101
    378 Bozeman Deaconess Hospital Bozeman Montana United States 59715
    379 Saint James Community Hospital and Cancer Treatment Center Butte Montana United States 59701
    380 Benefis Healthcare- Sletten Cancer Institute Great Falls Montana United States 59405
    381 Saint Peter's Community Hospital Helena Montana United States 59601
    382 Kalispell Regional Medical Center Kalispell Montana United States 59901
    383 Great Plains Health Callahan Cancer Center North Platte Nebraska United States 69101
    384 Nebraska Cancer Specialists/Oncology Hematology West PC - MECC Omaha Nebraska United States 68114
    385 Nebraska Methodist Hospital Omaha Nebraska United States 68114
    386 Oncology Associates PC Omaha Nebraska United States 68114
    387 Carson Tahoe Regional Medical Center Carson City Nevada United States 89703
    388 Cancer and Blood Specialists-Henderson Henderson Nevada United States 89052
    389 Comprehensive Cancer Centers of Nevada - Henderson Henderson Nevada United States 89052
    390 Comprehensive Cancer Centers of Nevada-Horizon Ridge Henderson Nevada United States 89052
    391 Las Vegas Cancer Center-Henderson Henderson Nevada United States 89052
    392 OptumCare Cancer Care at Seven Hills Henderson Nevada United States 89052
    393 Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson Nevada United States 89074
    394 GenesisCare USA - Henderson Henderson Nevada United States 89074
    395 Las Vegas Urology - Green Valley Henderson Nevada United States 89074
    396 Las Vegas Urology - Pebble Henderson Nevada United States 89074
    397 Urology Specialists of Nevada - Green Valley Henderson Nevada United States 89074
    398 Las Vegas Urology - Pecos Las Vegas Nevada United States 89074
    399 Desert West Surgery Las Vegas Nevada United States 89102
    400 OptumCare Cancer Care at Charleston Las Vegas Nevada United States 89102
    401 University Medical Center of Southern Nevada Las Vegas Nevada United States 89102
    402 Hope Cancer Care of Nevada Las Vegas Nevada United States 89103
    403 Cancer and Blood Specialists-Shadow Las Vegas Nevada United States 89106
    404 Radiation Oncology Centers of Nevada Central Las Vegas Nevada United States 89106
    405 Urology Specialists of Nevada - Central Las Vegas Nevada United States 89106
    406 GenesisCare USA - Las Vegas Las Vegas Nevada United States 89109
    407 HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Las Vegas Nevada United States 89109
    408 Sunrise Hospital and Medical Center Las Vegas Nevada United States 89109
    409 HealthCare Partners Medical Group Oncology/Hematology-San Martin Las Vegas Nevada United States 89113
    410 Las Vegas Prostate Cancer Center Las Vegas Nevada United States 89113
    411 Las Vegas Urology - Sunset Las Vegas Nevada United States 89113
    412 Urology Specialists of Nevada - Southwest Las Vegas Nevada United States 89113
    413 Radiation Oncology Centers of Nevada Southeast Las Vegas Nevada United States 89119
    414 Ann M Wierman MD LTD Las Vegas Nevada United States 89128
    415 Cancer and Blood Specialists-Tenaya Las Vegas Nevada United States 89128
    416 Comprehensive Cancer Centers of Nevada - Northwest Las Vegas Nevada United States 89128
    417 GenesisCare USA - Vegas Tenaya Las Vegas Nevada United States 89128
    418 HealthCare Partners Medical Group Oncology/Hematology-Tenaya Las Vegas Nevada United States 89128
    419 Las Vegas Urology - Cathedral Rock Las Vegas Nevada United States 89128
    420 Las Vegas Urology - Smoke Ranch Las Vegas Nevada United States 89128
    421 OptumCare Cancer Care at MountainView Las Vegas Nevada United States 89128
    422 Urology Specialists of Nevada - Northwest Las Vegas Nevada United States 89128
    423 Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas Nevada United States 89135
    424 Comprehensive Cancer Centers of Nevada - Town Center Las Vegas Nevada United States 89144
    425 Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas Nevada United States 89144
    426 Summerlin Hospital Medical Center Las Vegas Nevada United States 89144
    427 Las Vegas Cancer Center-Medical Center Las Vegas Nevada United States 89148-2405
    428 Comprehensive Cancer Centers of Nevada Las Vegas Nevada United States 89148
    429 GenesisCare USA - Fort Apache Las Vegas Nevada United States 89148
    430 OptumCare Cancer Care at Fort Apache Las Vegas Nevada United States 89148
    431 HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Las Vegas Nevada United States 89149
    432 Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas Nevada United States 89169
    433 University Cancer Center Las Vegas Nevada United States 89169
    434 Hope Cancer Care of Nevada-Pahrump Pahrump Nevada United States 89048
    435 Renown Regional Medical Center Reno Nevada United States 89502
    436 Saint Mary's Regional Medical Center Reno Nevada United States 89503
    437 Radiation Oncology Associates Reno Nevada United States 89509
    438 Dartmouth Hitchcock Medical Center Lebanon New Hampshire United States 03756
    439 Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey United States 07920
    440 Hackensack University Medical Center Hackensack New Jersey United States 07601
    441 Lovelace Medical Center-Saint Joseph Square Albuquerque New Mexico United States 87102
    442 University of New Mexico Cancer Center Albuquerque New Mexico United States 87102
    443 New Mexico Oncology Hematology Consultants Albuquerque New Mexico United States 87109
    444 Presbyterian Kaseman Hospital Albuquerque New Mexico United States 87110
    445 Presbyterian Rust Medical Center/Jorgensen Cancer Center Rio Rancho New Mexico United States 87124
    446 Christus Saint Vincent Regional Cancer Center Santa Fe New Mexico United States 87505
    447 Roswell Park Cancer Institute Buffalo New York United States 14263
    448 Memorial Sloan Kettering Commack Commack New York United States 11725
    449 Mary Imogene Bassett Hospital Cooperstown New York United States 13326
    450 Memorial Sloan Kettering Westchester Harrison New York United States 10604
    451 Memorial Sloan Kettering Cancer Center New York New York United States 10065
    452 University of Rochester Rochester New York United States 14642
    453 AdventHealth Infusion Center Asheville Asheville North Carolina United States 28803
    454 Southeastern Medical Oncology Center-Clinton Clinton North Carolina United States 28328
    455 Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina United States 27534
    456 Wayne Memorial Hospital Goldsboro North Carolina United States 27534
    457 Hendersonville Hematology and Oncology at Pardee Hendersonville North Carolina United States 28791
    458 Margaret R Pardee Memorial Hospital Hendersonville North Carolina United States 28791
    459 Onslow Memorial Hospital Jacksonville North Carolina United States 28546
    460 Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina United States 28546
    461 Vidant Oncology-Kenansville Kenansville North Carolina United States 28349
    462 Vidant Oncology-Kinston Kinston North Carolina United States 28501
    463 Vidant Oncology-Richlands Richlands North Carolina United States 28574
    464 Sanford Bismarck Medical Center Bismarck North Dakota United States 58501
    465 Essentia Health Cancer Center-South University Clinic Fargo North Dakota United States 58103
    466 Sanford South University Medical Center Fargo North Dakota United States 58103
    467 Sanford Broadway Medical Center Fargo North Dakota United States 58122
    468 Sanford Clinic North-Fargo Fargo North Dakota United States 58122
    469 Sanford Roger Maris Cancer Center Fargo North Dakota United States 58122
    470 Essentia Health - Jamestown Clinic Jamestown North Dakota United States 58401
    471 UHHS-Chagrin Highlands Medical Center Beachwood Ohio United States 44122
    472 Indu and Raj Soin Medical Center Beavercreek Ohio United States 45431
    473 Strecker Cancer Center-Belpre Belpre Ohio United States 45714
    474 Saint Elizabeth Boardman Hospital Boardman Ohio United States 44512
    475 Dayton Physicians LLC-Miami Valley South Centerville Ohio United States 45459
    476 Miami Valley Hospital South Centerville Ohio United States 45459
    477 Adena Regional Medical Center Chillicothe Ohio United States 45601
    478 Oncology Hematology Care Inc-Eden Park Cincinnati Ohio United States 45202
    479 Oncology Hematology Care Inc-Mercy West Cincinnati Ohio United States 45211
    480 University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio United States 45219
    481 Oncology Hematology Care Inc-Anderson Cincinnati Ohio United States 45230
    482 Oncology Hematology Care Inc-Kenwood Cincinnati Ohio United States 45236
    483 Oncology Hematology Care Inc-Blue Ash Cincinnati Ohio United States 45242
    484 Case Western Reserve University Cleveland Ohio United States 44106
    485 MetroHealth Medical Center Cleveland Ohio United States 44109
    486 Mount Carmel East Hospital Columbus Ohio United States 43213
    487 Columbus Oncology and Hematology Associates Inc Columbus Ohio United States 43214
    488 Riverside Methodist Hospital Columbus Ohio United States 43214
    489 Grant Medical Center Columbus Ohio United States 43215
    490 The Mark H Zangmeister Center Columbus Ohio United States 43219
    491 Mount Carmel Health Center West Columbus Ohio United States 43222
    492 Doctors Hospital Columbus Ohio United States 43228
    493 Good Samaritan Hospital - Dayton Dayton Ohio United States 45406
    494 Miami Valley Hospital Dayton Ohio United States 45409
    495 Dayton Physician LLC-Miami Valley Hospital North Dayton Ohio United States 45415
    496 Miami Valley Hospital North Dayton Ohio United States 45415
    497 Delaware Health Center-Grady Cancer Center Delaware Ohio United States 43015
    498 Grady Memorial Hospital Delaware Ohio United States 43015
    499 Columbus Oncology and Hematology Associates Dublin Ohio United States 43016
    500 Oncology Hematology Care Inc-Healthplex Fairfield Ohio United States 45014
    501 Armes Family Cancer Center Findlay Ohio United States 45840
    502 Blanchard Valley Hospital Findlay Ohio United States 45840
    503 Orion Cancer Care Findlay Ohio United States 45840
    504 Atrium Medical Center-Middletown Regional Hospital Franklin Ohio United States 45005-1066
    505 Dayton Physicians LLC-Atrium Franklin Ohio United States 45005
    506 Dayton Physicians LLC-Wayne Greenville Ohio United States 45331
    507 Wayne Hospital Greenville Ohio United States 45331
    508 Mount Carmel Grove City Hospital Grove City Ohio United States 43123
    509 Greater Dayton Cancer Center Kettering Ohio United States 45409
    510 Kettering Medical Center Kettering Ohio United States 45429
    511 Fairfield Medical Center Lancaster Ohio United States 43130
    512 Saint Rita's Medical Center Lima Ohio United States 45801
    513 OhioHealth Mansfield Hospital Mansfield Ohio United States 44903
    514 Marietta Memorial Hospital Marietta Ohio United States 45750
    515 OhioHealth Marion General Hospital Marion Ohio United States 43302
    516 Toledo Clinic Cancer Centers-Maumee Maumee Ohio United States 43537
    517 Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Maumee Ohio United States 43537
    518 UH Seidman Cancer Center at Lake Health Mentor Campus Mentor Ohio United States 44060
    519 Dayton Physicians LLC-Signal Point Middletown Ohio United States 45042
    520 Knox Community Hospital Mount Vernon Ohio United States 43050
    521 Licking Memorial Hospital Newark Ohio United States 43055
    522 Newark Radiation Oncology Newark Ohio United States 43055
    523 Saint Charles Hospital Oregon Ohio United States 43616
    524 Mercy Health Perrysburg Cancer Center Perrysburg Ohio United States 43551
    525 Southern Ohio Medical Center Portsmouth Ohio United States 45662
    526 UH Seidman Cancer Center at Firelands Regional Medical Center Sandusky Ohio United States 44870
    527 Dayton Physicians LLC-Wilson Sidney Ohio United States 45365
    528 Springfield Regional Cancer Center Springfield Ohio United States 45504
    529 Springfield Regional Medical Center Springfield Ohio United States 45505
    530 ProMedica Flower Hospital Sylvania Ohio United States 43560
    531 ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital Toledo Ohio United States 43606
    532 Saint Vincent Mercy Medical Center Toledo Ohio United States 43608
    533 Mercy Health - Saint Anne Hospital Toledo Ohio United States 43623
    534 Toledo Clinic Cancer Centers-Toledo Toledo Ohio United States 43623
    535 Dayton Physicians LLC-Upper Valley Troy Ohio United States 45373
    536 Upper Valley Medical Center Troy Ohio United States 45373
    537 Saint Joseph Warren Hospital Warren Ohio United States 44484
    538 University of Cincinnati Cancer Center-West Chester West Chester Ohio United States 45069
    539 Saint Ann's Hospital Westerville Ohio United States 43081
    540 UH Seidman Cancer Center at Saint John Medical Center Westlake Ohio United States 44145
    541 Saint Elizabeth Youngstown Hospital Youngstown Ohio United States 44501
    542 Genesis Healthcare System Cancer Care Center Zanesville Ohio United States 43701
    543 University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States 73104
    544 Saint Alphonsus Medical Center-Baker City Baker City Oregon United States 97814
    545 Saint Alphonsus Medical Center-Ontario Ontario Oregon United States 97914
    546 Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania United States 18103
    547 UPMC-Heritage Valley Health System Beaver Beaver Pennsylvania United States 15009
    548 Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania United States 18017
    549 Geisinger Medical Center Danville Pennsylvania United States 17822
    550 Pocono Medical Center East Stroudsburg Pennsylvania United States 18301
    551 UPMC Cancer Centers - Arnold Palmer Pavilion Greensburg Pennsylvania United States 15601
    552 Geisinger Medical Center-Cancer Center Hazleton Hazleton Pennsylvania United States 18201
    553 Lehigh Valley Hospital-Hazleton Hazleton Pennsylvania United States 18201
    554 UPMC-Johnstown/John P. Murtha Regional Cancer Center Johnstown Pennsylvania United States 15901
    555 Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania United States 17837
    556 Lewistown Hospital Lewistown Pennsylvania United States 17044
    557 UPMC Cancer Center at UPMC McKeesport McKeesport Pennsylvania United States 15132
    558 UPMC-Coraopolis/Heritage Valley Radiation Oncology Moon Pennsylvania United States 15108
    559 UPMC-Magee Womens Hospital Pittsburgh Pennsylvania United States 15213
    560 UPMC-Presbyterian Hospital Pittsburgh Pennsylvania United States 15213
    561 UPMC-Saint Margaret Pittsburgh Pennsylvania United States 15215
    562 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh Pennsylvania United States 15232
    563 UPMC-Shadyside Hospital Pittsburgh Pennsylvania United States 15232
    564 UPMC-Passavant Hospital Pittsburgh Pennsylvania United States 15237
    565 UPMC-Saint Clair Hospital Cancer Center Pittsburgh Pennsylvania United States 15243
    566 Geisinger Cancer Services-Pottsville Pottsville Pennsylvania United States 17901
    567 Guthrie Medical Group PC-Robert Packer Hospital Sayre Pennsylvania United States 18840
    568 Community Medical Center Scranton Pennsylvania United States 18510
    569 Geisinger Medical Oncology-Selinsgrove Selinsgrove Pennsylvania United States 17870
    570 UPMC Cancer Center at UPMC Northwest Seneca Pennsylvania United States 16346
    571 Geisinger Medical Group State College Pennsylvania United States 16801
    572 UPMC Uniontown Hospital Radiation Oncology Uniontown Pennsylvania United States 15401
    573 UPMC Washington Hospital Radiation Oncology Washington Pennsylvania United States 15301
    574 Reading Hospital West Reading Pennsylvania United States 19611
    575 Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania United States 18711
    576 UPMC Susquehanna Williamsport Pennsylvania United States 17701
    577 Saint Joseph's/Candler - Bluffton Campus Bluffton South Carolina United States 29910
    578 Saint Francis Hospital Greenville South Carolina United States 29601
    579 Saint Francis Cancer Center Greenville South Carolina United States 29607
    580 South Carolina Cancer Specialists PC Hilton Head Island South Carolina United States 29926-3827
    581 Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota United States 57104
    582 Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota United States 57117-5134
    583 Vanderbilt-Ingram Cancer Center Cool Springs Franklin Tennessee United States 37067
    584 Thompson Cancer Survival Center Knoxville Tennessee United States 37916
    585 Thompson Cancer Survival Center - West Knoxville Tennessee United States 37932
    586 Thompson Oncology Group-Maryville Maryville Tennessee United States 37804
    587 Vanderbilt Breast Center at One Hundred Oaks Nashville Tennessee United States 37204
    588 Vanderbilt University/Ingram Cancer Center Nashville Tennessee United States 37232
    589 Thompson Oncology Group-Oak Ridge Oak Ridge Tennessee United States 37830
    590 Parkland Memorial Hospital Dallas Texas United States 75235
    591 UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas United States 75390
    592 Farmington Health Center Farmington Utah United States 84025
    593 Huntsman Cancer Institute/University of Utah Salt Lake City Utah United States 84112
    594 South Jordan Health Center South Jordan Utah United States 84009
    595 University of Vermont Medical Center Burlington Vermont United States 05401
    596 University of Vermont and State Agricultural College Burlington Vermont United States 05405
    597 University of Virginia Cancer Center Charlottesville Virginia United States 22908
    598 Hematology Oncology Associates of Fredericksburg Inc Fredericksburg Virginia United States 22408
    599 Centra Lynchburg Hematology-Oncology Clinic Inc Lynchburg Virginia United States 24501
    600 Virginia Cancer Institute Richmond Virginia United States 23229
    601 Virginia Commonwealth University/Massey Cancer Center Richmond Virginia United States 23298
    602 Shenandoah Oncology PC Winchester Virginia United States 22601
    603 Overlake Medical Center Bellevue Washington United States 98004
    604 Jefferson Healthcare Port Townsend Washington United States 98368
    605 Valley Medical Center Renton Washington United States 98055
    606 North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima Washington United States 98902
    607 Edwards Comprehensive Cancer Center Huntington West Virginia United States 25701
    608 Langlade Hospital and Cancer Center Antigo Wisconsin United States 54409
    609 Duluth Clinic Ashland Ashland Wisconsin United States 54806
    610 Northwest Wisconsin Cancer Center Ashland Wisconsin United States 54806
    611 Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin United States 53105
    612 Marshfield Clinic-Chippewa Center Chippewa Falls Wisconsin United States 54729
    613 Aurora Saint Luke's South Shore Cudahy Wisconsin United States 53110
    614 Marshfield Clinic Cancer Center at Sacred Heart Eau Claire Wisconsin United States 54701
    615 Aurora Health Center-Fond du Lac Fond Du Lac Wisconsin United States 54937
    616 Aurora Health Care Germantown Health Center Germantown Wisconsin United States 53022
    617 Aurora Cancer Care-Grafton Grafton Wisconsin United States 53024
    618 Bellin Memorial Hospital Green Bay Wisconsin United States 54301
    619 Aurora BayCare Medical Center Green Bay Wisconsin United States 54311
    620 UW Cancer Center Johnson Creek Johnson Creek Wisconsin United States 53038
    621 Aurora Cancer Care-Kenosha South Kenosha Wisconsin United States 53142
    622 Gundersen Lutheran Medical Center La Crosse Wisconsin United States 54601
    623 University of Wisconsin Carbone Cancer Center Madison Wisconsin United States 53792
    624 Aurora Bay Area Medical Group-Marinette Marinette Wisconsin United States 54143
    625 Marshfield Medical Center-Marshfield Marshfield Wisconsin United States 54449
    626 Aspirus Medford Hospital Medford Wisconsin United States 54451
    627 Aurora Cancer Care-Milwaukee Milwaukee Wisconsin United States 53209
    628 Aurora Saint Luke's Medical Center Milwaukee Wisconsin United States 53215
    629 Medical College of Wisconsin Milwaukee Wisconsin United States 53226
    630 Aurora Sinai Medical Center Milwaukee Wisconsin United States 53233
    631 Marshfield Clinic-Minocqua Center Minocqua Wisconsin United States 54548
    632 ProHealth D N Greenwald Center Mukwonago Wisconsin United States 53149
    633 Cancer Center of Western Wisconsin New Richmond Wisconsin United States 54017
    634 ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin United States 53066
    635 Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin United States 54904
    636 Aurora Cancer Care-Racine Racine Wisconsin United States 53406
    637 Lakeview Medical Center-Marshfield Clinic Rice Lake Wisconsin United States 54868
    638 Marshfield Medical Center-Rice Lake Rice Lake Wisconsin United States 54868
    639 Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin United States 53081
    640 Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin United States 54482
    641 Aurora Medical Center in Summit Summit Wisconsin United States 53066
    642 Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin United States 54241
    643 Aurora Cancer Care-Waukesha Waukesha Wisconsin United States 53188
    644 ProHealth Waukesha Memorial Hospital Waukesha Wisconsin United States 53188
    645 UW Cancer Center at ProHealth Care Waukesha Wisconsin United States 53188
    646 Aspirus Regional Cancer Center Wausau Wisconsin United States 54401
    647 Marshfield Clinic-Wausau Center Wausau Wisconsin United States 54401
    648 Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin United States 53226
    649 Aurora West Allis Medical Center West Allis Wisconsin United States 53227
    650 Marshfield Medical Center - Weston Weston Wisconsin United States 54476
    651 Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids Wisconsin United States 54494
    652 Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids Wisconsin United States 54494

    Sponsors and Collaborators

    • National Cancer Institute (NCI)

    Investigators

    • Principal Investigator: Frank S Hodi, ECOG-ACRIN Cancer Research Group

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    National Cancer Institute (NCI)
    ClinicalTrials.gov Identifier:
    NCT02339571
    Other Study ID Numbers:
    • NCI-2014-02674
    • NCI-2014-02674
    • EA6141
    • EA6141
    • EA6141
    • U10CA180820
    • U24CA196172
    First Posted:
    Jan 15, 2015
    Last Update Posted:
    Aug 17, 2022
    Last Verified:
    Aug 1, 2022
    Additional relevant MeSH terms:
    Melanoma
    Skin Neoplasms
    Nivolumab
    Ipilimumab
    Sargramostim

    Study Results

    No Results Posted as of Aug 17, 2022