MAA: Microarray Analysis of Gene Expression in Idiopathic Pulmonary Fibrosis (IPF)

Sponsor
University of Pittsburgh (Other)
Overall Status
Active, not recruiting
CT.gov ID
NCT00258544
Collaborator
(none)
80
1
285
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Study Details

Study Description

Brief Summary

This study is investigating the way the lung is damaged in a condition called pulmonary fibrosis. Research studies will be conducted on lung tissue obtained from an open lung biopsy performed by the subject's surgeon. The identification of unique genetic markers of scarred lung may ultimately lead to new approaches to the diagnosis and treatment of pulmonary fibrosis.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Subjects are being asked to participate in a research study that is investigating the way the lung is damaged in a condition called pulmonary fibrosis. These research studies are conducted in the laboratory on a portion of the tissue from the subject's lung biopsy that was performed by a surgeon. The lung biopsy is to be performed for clinical purposes to diagnose the cause of the subject's lung disease. The tissue used for the research study will in no way interfere with the ability of the pathologist to establish a diagnosis. In addition, the results of your breathing tests, chest X-rays and CT scans, and diagnosis made from the lung biopsy (and slides) will be collected. The goal of the study is to gain an understanding of the causes of pulmonary fibrosis and why it gets worse, which may ultimately lead to new therapies for this disease. Once the lung biopsies are obtained, the pathologist will examine the tissue and determine if there is a sufficient amount available to use in the study without compromising their ability to make a diagnosis. If so, the lung biopsy will be divided. One portion will be submitted to the research study and the other processed by the pathologist in the usual manner to make a diagnosis. The decision to use tissue for the research study will be at the complete discretion of the pathologists. The tissue used in the study will be further processed in the laboratory in order to analyze for the presence of genetic markers in the scarred tissue that are not present in normal. The identification of these unique genetic markers of scarred lung may ultimately lead to new approaches to the diagnosis and treatment of pulmonary fibrosis.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    80 participants
    Observational Model:
    Cohort
    Time Perspective:
    Other
    Official Title:
    Microarray Analysis of Gene Expression in Idiopathic Pulmonary Fibrosis
    Study Start Date :
    Oct 1, 2001
    Anticipated Primary Completion Date :
    Jul 1, 2025
    Anticipated Study Completion Date :
    Jul 1, 2025

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:
      • 18 years or age or older

      • Diagnosis of pulmonary fibrosis

      • Undergoing open lung biopsy

      Exclusion Criteria:
      • N/A

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 University of Pittsburgh Pittsburgh Pennsylvania United States 15213

      Sponsors and Collaborators

      • University of Pittsburgh

      Investigators

      • Principal Investigator: Kevin F Gibson, MD, University of Pittsburgh - Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease

      Study Documents (Full-Text)

      None provided.

      More Information

      Additional Information:

      Publications

      None provided.
      Responsible Party:
      Kevin F. Gibson, Professor of Medicine, University of Pittsburgh
      ClinicalTrials.gov Identifier:
      NCT00258544
      Other Study ID Numbers:
      • 010462
      First Posted:
      Nov 24, 2005
      Last Update Posted:
      Nov 3, 2021
      Last Verified:
      Nov 1, 2021
      Keywords provided by Kevin F. Gibson, Professor of Medicine, University of Pittsburgh
      Additional relevant MeSH terms:

      Study Results

      No Results Posted as of Nov 3, 2021