Microbiological Profile of VAP Patients in Respiratory ICU

Sponsor

Assiut University (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT05738928

Collaborator

(none)

Enrollment

Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

Identification of the microbial profile of Ventilator associated pneumonia causing microorganisms among Respiratory ICU patients .

Condition or Disease	Intervention/Treatment	Phase
VAP - Ventilator Associated Pneumonia	Diagnostic Test: blood and sputum culture

Detailed Description

Ventilator-associated pneumonia (VAP) is one of the common serious infectious diseases encountered in the intensive care unit (ICU), which highly affects the healthcare cost and patient prognosis.

All-cause of mortality associated with VAP has been reported to range from 20% to 50%.

The etiology of VAP and their antimicrobial susceptibility pattern varies with different patient populations and types of ICUs.

VAP may be caused by a wide spectrum of bacterial pathogens, which may be polymicrobial and are rarely due to viral or fungal pathogens in immune-competent hosts.

Common etiologic agents are Gram-negative bacilli such as Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Acinetobacter spp. and Staphylococcus aureus among Gram-positive cocci.

Due to the increased incidence of MDR organisms in Intensive Care Units (ICUs), early and correct diagnosis of VAP is mandatory for optimal antibiotic therapy. The frequency of specific MDR pathogens causing VAP varies in hospitals, patient populations. Also varies according underlying disease.

this study will be conducted in respiratory intensive care unit, chest disease and tuberculosis department at Assiut university hospitals.

Study Design

Study Type:

Observational

Anticipated Enrollment :

86 participants

Observational Model:

Case-Only

Time Perspective:

Prospective

Official Title:

Microbiological Profile of Ventilator Associated Pneumonia in Respiratory Intensive Care Unit of Assiut University Hospital

Anticipated Study Start Date :

Feb 1, 2023

Anticipated Primary Completion Date :

Dec 1, 2023

Anticipated Study Completion Date :

Feb 1, 2024

Outcome Measures

Primary Outcome Measures

Microbiological profile of ventilator associated pneumonia in Respiratory ICU in Assiut University Hospital. [1 year]
Identify the microbial profile of VAP causing microorganisms among ICU patients, antimicrobial susceptibility patterns among the frequently isolated organisms and resistant strains.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Mechanically ventilated patient who developed pneumonia after48 hours after endotracheal intubation.
Age > 18 years.

Exclusion Criteria:

Patients with clinical and radiological signs suggestive of pneumonia before intubation (community acquired pneumonia or hospital acquired pneumonia)
Patients age ≤18 years old

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

Assiut University

Investigators

Study Director: mohammed M Abdelhadi, PhD, Assiut University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Manar Abdelhameed Hassan Ali, Doctor, Assiut University

ClinicalTrials.gov Identifier:

NCT05738928

Other Study ID Numbers:

Microbiological profile of VAP

First Posted:

Feb 22, 2023

Last Update Posted:

Feb 22, 2023

Last Verified:

Feb 1, 2023

Individual Participant Data (IPD) Sharing Statement:

Undecided

Plan to Share IPD:

Undecided

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Additional relevant MeSH terms:

Pneumonia

Pneumonia, Ventilator-Associated

Study Results

No Results Posted as of Feb 22, 2023