Copy Number Variation in CHRNA7 Gene in Migraine and Gene Expression
Study Details
Study Description
Brief Summary
Migraine is a common and possible hereditary disease. Copy number variation (CNV) is a phenomenon in which parts of the genome are repeated and the number of repeats in the genome varies between individuals in the human population.The CHRNA7 gene has a major role in the neuropsychiatric phenotypes observed in patients. The 15q13.3 gain/loss variation in this gene may be associated with migraine.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Detailed Description
Migraine is a common neurological disorder. Although they have different genetic bases according to their types, cholinergic receptors after calcium channels play an important role in the clinic and genetics of the disease. Neuronal acetylcholine receptor subunit alpha-7, also known as nAChRα7, is a protein that in humans is encoded by the CHRNA7 gene.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Other: Case-Control Copy number variation |
Genetic: Migraine CNV
Copy number variation effect on migraine disease
|
Experimental: Case-Control 1 Gene expression |
Genetic: Migraine CNV
Copy number variation effect on migraine disease
|
Outcome Measures
Primary Outcome Measures
- CNV number [1 year]
CNV number effect on migraine
Eligibility Criteria
Criteria
Inclusion Criteria:
Migraine
Exclusion Criteria:
Vascular problems
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Medicine | Gaziantep | Şehitkamil | Turkey | 27310 |
Sponsors and Collaborators
- University of Gaziantep
Investigators
- Principal Investigator: Mehmet Fatih Özaltun, MD, Assist
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2020/12