Pred-lung: Multi-dimensional Signatures for Precisely Predicting the Response and Prognosis of Lung Cancer Patients
Study Details
Study Description
Brief Summary
This study aims to determine the clinical effectiveness of multi-dimensional signatures in predicting response and prognosis of lung cancer patients. The study is a multi-center perspective research of treatment planning for patients with lung cancer. To characterize clinical effectiveness, the progression-free survival (PFS) and overall survival (OS) impacts of multi-dimensional signatures will be estimated.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Multi-dimensional signatures, including NGS-based genotyping, and other essential detections such as immunohistochemistry (IHC), provides an opportunity to improve outcomes for patients by tailoring treatments to each individual's genomic profile. This is a multi-center single arm research study integrating multi-dimensional signatures into clinical decision-making for patients with lung cancer. The clinical effectiveness of multi-dimensional signatures is unknown in the real-world of clinics. To identify a counterfactual for Pred-lung approach, matching methods combined with administrative healthcare data will be used. The survival impacts of Pred-lung approach compared to usual care in matched controls will then be estimated.
Study Design
Outcome Measures
Primary Outcome Measures
- PFS [through study completion, an average of 6 months]
Progression-free survival
Secondary Outcome Measures
- OS [through study completion, an average of 1 year]
Overall survival
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patients with locally-advanced or metastasis lung cancer
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Life expectancy > 3 months
Exclusion Criteria:
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Age at diagnosis <18
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refuse to enroll
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Wuhan Union Hospital | Wuhan | Hubei | China | 430000 |
Sponsors and Collaborators
- Wuhan Union Hospital, China
- Renmin Hospital of Wuhan University
- Wuhan TongJi Hospital
- Wuhan University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2019-1-12 V1.1