DRAMMATIC: S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration

Southwest Oncology Group (Other)
Overall Status
CT.gov ID
National Cancer Institute (NCI) (NIH), Janssen, LP (Industry), Adaptive (Other)
Anticipated Duration (Months)
Patients Per Site
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Patients are enrolled to screening (Reg Step 1) prior to or after ASCT but prior to Reg Step 2. Patients are followed until they will begin Maintenance and then registered to Reg Step 2 (first randomization). Patients are randomized between Lenalidomide for 2 years and Lenalidomide + Daratumumab/rHuPH20. After 2 years of Maintenance, MRD is assessed to guide further therapy. MRD-positive patients will continue with the assigned treatment. MRD-negative patients will be further randomized (Reg Step 3) to either continue or discontinue the assigned treatment. Patients are treated for up to 7 years from Step 2 reg and followed for up to 15 years.

Condition or DiseaseIntervention/TreatmentPhase
Phase 3

Study Design

Study Type:
Anticipated Enrollment :
1100 participants
Intervention Model:
Parallel Assignment
None (Open Label)
Primary Purpose:
Official Title:
S1803, Phase III Study of Daratumumab/rHuPH20 (NSC-810307) + Lenalidomide or Lenalidomide as Post-Autologous Stem Cell Transplant Maintenance Therapy in Patients With Multiple Myeloma (MM) Using Minimal Residual Disease to Direct Therapy Duration (DRAMMATIC Study)
Actual Study Start Date :
Jun 27, 2019
Anticipated Primary Completion Date :
Jul 1, 2029
Anticipated Study Completion Date :
Jul 1, 2040

Arms and Interventions

No Intervention: Study Entry / Screening

Study entry/screening to follow patient until Maintenance.

Active Comparator: Arm 1: Lenalidomide

Lenalidomide 10 mg/day, D1-28, q28 days for 3 cycles, then 15 mg/day, D1-28 for up to 2 years from starting treatment.

Drug: Lenalidomide
Commercially available intervention
Other Names:
  • CC-5013
  • Revlimid
  • Experimental: Arm 2: Lenalidomide + Daratumumab/rHuPH20

    Lenalidomide 10 mg/day, D1-28, q28 days for 3 cycles, then 15 mg/day, D1-28 for up to 2 years from starting treatment. Plus Daratumumab/rHuPH20 1800 mg/30,000 units D1, 8, 15, 22 q 28 days for 2 cycles, then D 1 and 15 q 28 days for cycles 3-6 then D1 q 28 days for subsequent cycles for up to 2 years from starting treatment.

    Drug: Lenalidomide
    Commercially available intervention
    Other Names:
  • CC-5013
  • Revlimid
  • Drug: Daratumumab/rHuPH20
    SWOG-Held IND

    Active Comparator: Arm 1a: Continue Lenalidomide

    MRD+ or MRD- and randomized to Arm 1a: Lenalidomide 10 mg/day, D1-28, q28 days for 3 cycles, then 15 mg/day, D1-28 for up to 7 years from starting treatment.

    Drug: Lenalidomide
    Commercially available intervention
    Other Names:
  • CC-5013
  • Revlimid
  • No Intervention: Arm 1b: Stop Lenalidomide

    MRD- and randomized to Arm 1b: Discontinue protocol therapy.

    Active Comparator: Arm 2a: Continue Lenalidomide + Daratumumab/rHuPH20

    MRD+ or MRD- and randomized to Arm 2a: Lenalidomide 10 mg/day, D1-28, q28 days for 3 cycles, then 15 mg/day, D1-28 for up to 7 years from starting treatment. Plus Daratumumab/rHuPH20 1800 mg/30,000 units D1, 8, 15, 22 q 28 days for 2 cycles, then D 1 and 15 q 28 days for cycles 3-6 then D1 q 28 days for subsequent cycles for up to 7 years from starting treatment.

    Drug: Lenalidomide
    Commercially available intervention
    Other Names:
  • CC-5013
  • Revlimid
  • Drug: Daratumumab/rHuPH20
    SWOG-Held IND

    No Intervention: Arm 2b: Stop Lenalidomide + Daratumumab/rHuPH20

    MRD- and randomized to Arm 2b: Discontinue protocol therapy.

    Outcome Measures

    Primary Outcome Measures

    1. Overall Survival [From date of intial randomization until death due to any cause, assessed up to 15 years]

      Overall survival will evaluated using a weighted log-rank test and will be compared between primary treatment arms. All eligible patients with valid consent will be included in the analysis. Patients last known to be alive are censored at the date of last contact.

    Secondary Outcome Measures

    1. Progression Free Survival [From date of intial randomization until progression or death due to any cause, whichever occurs first, assessed up to 7 years]

      Progression-free survival will evaluated using a weighted log-rank test and will be compared between primary treatment arms. All eligible patients with valid consent will be included in the analysis. Patients last known to be progression-free and alive are censored at the date of last contact.

    2. Response (PR or better) [From date of initial randomization until date of best response while on study treatment.]

      Per International Uniform Response Criteria for Multiple Myeloma PR- ≥ 50% reduction in size of soft tissue plasmacytomas & plasma cells; ≥ 50% decrease in serum & reduction in urine M protein ≥ 90% or to < 200 mg/24hr or ≥ 50% decrease in difference in uninvolved & involved serum free light chain levels; VGPR- PR + Serum and urine M proteins detectable by immunofixation but not on electrophoresis or ≥ 90% reduction in serum M protein & urine M protein < 100 mg/24 hrs; uPR- 1 objective status of PR, but confirmation studies are not done, or do not meet the requirements necessary to confirm response; SD- does not meet criteria for sCR, CR, VGPR, PR or PROG; PROG- new or increase in size of existing bone lesions or soft tissue plasmacytomas/ development of hypercalcemia attributable solely to MM/ ≥ 25% increase from baseline/ lowest response level of either serum or Urine M protein, difference in involved & uninvolved serum free light chain level or bone marrow plasma cell percentage.

    3. MRD Negativity [24 months from initial randomization]

      The rate of MRD response will be calculated as the number of patients who achieved MRD response divided by the number of eligible patients; patients without a conclusive MRD results will be included as non-responders. Comparisons between arms will be made using a stratified Cochran-Mantel-Haenszel test. MRD data will be collected from the central testing laboratory, including percent of cells detected and total cells collected. Unless the sample is limiting, 5 x 106 events are collected for a standard multiple myeloma MRD sensitivities of 0.0001%. MRD negativity will be defined as no templates observed at a sensitivity of 1 in a million cells assessed, with a minimum of 1 million cells being assessed. MRD positivity will be defined as any templates observed regardless of the number of cells analyzed, or non-diagnostic specimens, including if the reference specimen from diagnosis is not able to be sequenced.

    Other Outcome Measures

    1. Toxicity assessment [From the time of intial randomization for up to 7 years.]

      All randomized patients that have initiated treatment will be considered evaluable for toxicity analyses. The maximum Grade for each toxicity will be recorded for each patient, and frequency tables will be reviewed to determine toxicity patterns.

    Eligibility Criteria


    Ages Eligible for Study:
    18 Years to 75 Years
    Sexes Eligible for Study:
    Accepts Healthy Volunteers:

    Registration Step 1 Except where otherwise indicated below that test is required in a shorter timeframe, all tests for establishing baseline disease status must be completed within 60 days prior to registration. All test results must be documented on the Baseline Tumor Assessment Form for Multiple Myeloma and the Onstudy Form.

    Inclusion Criteria

    • Patients must have had a confirmed diagnosis of symptomatic multiple myeloma (See Section 4.1) that required systemic induction therapy prior to autologous stem cell transplantation (ASCT).

    • Patients with disease measurable by serum light chain assay alone are eligible (defined as >/= 100 mg/L on involved light chain).

    • Patients must be registered to Step 1 prior to registration to Step 2. Registration to Step 1 may take place prior to or after autologous stem cell transplant (ASCT), but after completion of induction therapy.

    • Patients must have initiated induction therapy within 12 months prior to registration Step 1 and have received at least two cycles of induction therapy.

    • Patients must be willing and able to take DVT prophylaxis (aspirin, low molecular weight heparin, warfarin, or equivalent oral anticoagulation).

    • Patients must be >/= 18 and </= 75 years of age at time of registration to Step 1.

    • Patients must have history and physical exam within 28 days prior to registration.

    • Patients must have Zubrod Performance Status </= 2.

    • Patients must have evidence of adequate renal function, as defined by (1) creatinine clearance (CrCl) >/= 30 mL/min., as measured by a 24-hour urine collection, or estimated by the Cockcroft and Gault formula, or (2) serum creatinine < 2.5 mg/dL. Values must be obtained within 28 days prior to registration.

    • Patients must have adequate hepatic function defined by the following within 42 days prior to registration:

    • Total bilirubin </=1.5 x IULN (institutional upper limit of the norm) AND

    • AST and ALT </=3.0 x IULN

    • Patients must meet one of the following criteria:

    • Be acceptable for transplant per institutional guidelines and the criteria evidencing this must be documented on the S1803 Onstudy Form. (See Appendix 18.3 for standard transplant eligibility guidelines. Note that these are guidelines and not required criteria.) OR

    • Have completed autologous stem cell transplant within 180 days prior to registration (see also Section 5.2a).

    • Patient's with human immunodeficiency virus (HIV) are eligible providing they are on effective antiretroviral therapy and have undetectable viral load at their most previous viral load test and within 6 months prior to registration.

    • Patients must be able to take and swallow oral medication (capsules) whole. Patients may not have any known impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of study drug (e.g. ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, or small bowel resection).

    • For patients who have not yet received transplant: Patients must be willing and able to return to the transplant center for their assigned treatment after randomization. Note that patients need not have a direct relationship with the transplant center in order to register.

    • Patients must submit specimens for MRD as outlined in Section 15.1. See Section 15.1 for further information, including specimen submission timepoints. Note that patients are not ineligible based solely on archival specimens being unavailable.

    • Patients must be offered participation in specimen banking for future research. With patient's consent, specimens must be submitted as outlined in Section 15.2.

    • Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.

    • As a part of the OPEN registration process (see Section 13.3 for OPEN access instructions) the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system.

    Exclusion Criteria

    • Patients with smoldering myeloma are not eligible. Patients with purely non-secretory MM as measured by electrophoresis and immunofixation and the absence of Bence Jones proteins in the urine are not eligible. Patients must have measurable M protein in the serum (defined as >/= 0.5g/dL) or urine (defined as >/= 200 mg/24h). Patients with plasma cell leukemia are not eligible.

    • Patients must not have any organ involvement by amyloidosis or evidence of amyloidosis related organ dysfunction.

    • Patients must not have progressive disease at any time prior to registration.

    • Patients must not be refractory to either lenalidomide or daratumumab/rHuPH20.

    • Patients must not be intolerant to either lenalidomide or daratumumab/rHuPH20.

    • Patients must not have received any investigational agents within 14 days prior to registration.

    • Patients must not have chronic obstructive pulmonary disease with a forced expiratory volume in 1 second (FEV1) < 50% of predicted normal. FEV1 is required for patients suspected of having chronic obstructive pulmonary disease and are not eligible if FEV1 is < 50% of predicted normal.

    • Patients must not have moderate or severe persistent asthma within the past 2 years and must not have currently uncontrolled asthma of any classification.

    • Patients must not have had prior autograft or allograft, or prior organ transplant requiring immunosuppressive therapy.

    • Patients must not have known allergy to any of the study drugs.

    • Patients with uncontrolled bacterial, viral or fungal infections (currently taking medication and with progression or no clinical improvement) at time of enrollment are not eligible.

    • Patients must not have known central nervous system (CNS) involvement with multiple myeloma, defined as CSF positivity for plasma cells at any time or a parenchymal CNS plasmacytoma at time of enrollment. Lumbar puncture is not required.

    • Patients must not be seropositive for hepatitis C (except in the setting of sustained virologic response, defined as undetectable viral load at least 12 weeks after completion of antiviral therapy). HCV testing is only required if clinically indicated or if the patient has a history of HCV.

    • No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated Stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for three years.

    • Patients must not have any uncontrolled intercurrent illness including (not limited to): Symptomatic CHF (NYHA III/IV), unstable angina pectoris or coronary angioplasty, or stenting within 6 months prior to registration, Unstable cardiac arrhythmia (ongoing cardiac dysrhythmias of NCI CTCAE v5.0 Grade >/= 2), intra-cardiac defibrillators, known cardiac metastases, or abnormal cardiac valve morphology (>/= Grade 3), or known psychiatric illness that would limit study compliance.

    Registration Step 2 - First Randomization (Post-ASCT, Pre-Maintenance)

    Inclusion Criteria:
    • Patients must have completed ASCT within 180 days prior to registering to Step 2.

    • Patients must have one of the following performed within 60 days prior to registration for disease assessment: diagnostic quality skeletal survey, whole body CT scan, MRI, or PET.

    • Patients must have Zubrod Performance Status </= 2

    • Patients must have adequate bone marrow function as evidenced by platelets >/= 75,000/mm3 and ANC >/= 1,000/mm3 within 28 days prior to first randomization:

    • Patients must have adequate hepatic function defined by the following within 28 days prior to first randomization:

    • Total bilirubin </=1.5 x IULN (institutional upper limit of the norm) AND AST and ALT </=3.0 x IULN

    • Patients must have evidence of adequate renal function, as defined by creatinine clearance (CrCl) >/= 30 mL/min., as measured by a 24-hour urine collection, or estimated by the Cockcroft and Gault formula, or have a serum creatinine < 2.5 mg/dL within 28 days prior to first randomization.

    • All ASCT-related toxicities must have recovered to </=Grade 1 (except for alopecia, fatigue and amenorrhea) prior to first randomization.

    • Mucositis and gastrointestinal symptoms must have resolved to </=Grade 1.

    • Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10-14 days prior to registration.

    • FCBP must agree to have a second pregnancy test within 24 hours prior to starting Cycle 1. Further, FCBP must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control: one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before starting lenalidomide. FCBP must also agree to ongoing pregnancy testing and must agree to not become pregnant for at least 3 months after the last dose of study treatment.

    • Men must agree to use a latex condom during sexual contact with a FCBP, even if they have had a successful vasectomy, during the study treatment and for 3 months after the last dose of study treatment.

    • Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.

    Exclusion Criteria:
    • Patients must not have received any other maintenance therapy post-ASCT and prior to Step 2 registration.

    • Patients must not have had progressive disease between induction and registration to Registration Step 2. (See Section 10.1b).

    Registration Step 3 - Second Randomization (Post 24 Months Maintenance)

    Inclusion Criteria:
    • Patients must have completed 24 cycles of protocol maintenance with either lenalidomide or lenalidomide + daratumumab/rHuPH20.

    • Patients must have 24-month MRD by NGS test results available and must be MRD negative. Patients whose PCR results are indeterminable will be considered to have positive results.

    • Patients must be in very good partial remission (VGPR) or better by IMWG response criteria (see Section 10.1b).

    Contacts and Locations


    SiteCityStateCountryPostal Code
    1Anchorage Associates in Radiation MedicineAnchorageAlaskaUnited States98508
    2Anchorage Radiation Therapy CenterAnchorageAlaskaUnited States99504
    3Alaska Breast Care and Surgery LLCAnchorageAlaskaUnited States99508
    4Alaska Oncology and Hematology LLCAnchorageAlaskaUnited States99508
    5Alaska Women's Cancer CareAnchorageAlaskaUnited States99508
    6Anchorage Oncology CentreAnchorageAlaskaUnited States99508
    7Katmai Oncology GroupAnchorageAlaskaUnited States99508
    8Providence Alaska Medical CenterAnchorageAlaskaUnited States99508
    9Cancer Center at Saint Joseph'sPhoenixArizonaUnited States85004
    10University of Arizona Cancer Center-Orange Grove CampusTucsonArizonaUnited States85704
    11Banner University Medical Center - TucsonTucsonArizonaUnited States85719
    12University of Arizona Cancer Center-North CampusTucsonArizonaUnited States85719
    13Mercy Hospital Fort SmithFort SmithArkansasUnited States72903
    14CHI Saint Vincent Cancer Center Hot SpringsHot SpringsArkansasUnited States71913
    15University of Arkansas for Medical SciencesLittle RockArkansasUnited States72205
    16Kaiser Permanente-Deer Valley Medical CenterAntiochCaliforniaUnited States94531
    17Mission Hope Medical Oncology - Arroyo GrandeArroyo GrandeCaliforniaUnited States93420
    18Providence Saint Joseph Medical Center/Disney Family Cancer CenterBurbankCaliforniaUnited States91505
    19City of Hope Comprehensive Cancer CenterDuarteCaliforniaUnited States91010
    20Epic Care-DublinDublinCaliforniaUnited States94568
    21Kaiser Permanente DublinDublinCaliforniaUnited States94568
    22Bay Area Breast Surgeons IncEmeryvilleCaliforniaUnited States94608
    23Epic Care Partners in Cancer CareEmeryvilleCaliforniaUnited States94608
    24Kaiser Permanente-FremontFremontCaliforniaUnited States94538
    25Fresno Cancer CenterFresnoCaliforniaUnited States93720
    26Kaiser Permanente-FresnoFresnoCaliforniaUnited States93720
    27Cedars Sinai Medical CenterLos AngelesCaliforniaUnited States90048
    28Contra Costa Regional Medical CenterMartinezCaliforniaUnited States94553-3156
    29Fremont - Rideout Cancer CenterMarysvilleCaliforniaUnited States95901
    30Kaiser Permanente-ModestoModestoCaliforniaUnited States95356
    31Alta Bates Summit Medical Center - Summit CampusOaklandCaliforniaUnited States94609
    32Bay Area Tumor InstituteOaklandCaliforniaUnited States94609
    33Kaiser Permanente Oakland-BroadwayOaklandCaliforniaUnited States94611
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    35UC Irvine Health/Chao Family Comprehensive Cancer CenterOrangeCaliforniaUnited States92868
    36Desert Regional Medical CenterPalm SpringsCaliforniaUnited States92262
    37Kaiser Permanente-Rancho Cordova Cancer CenterRancho CordovaCaliforniaUnited States95670
    38Kaiser Permanente- Marshall Medical OfficesRedwood CityCaliforniaUnited States94063
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    40Kaiser Permanente-RichmondRichmondCaliforniaUnited States94801
    41Rohnert Park Cancer CenterRohnert ParkCaliforniaUnited States94928
    42Kaiser Permanente-RosevilleRosevilleCaliforniaUnited States95661
    43The Permanente Medical Group-Roseville Radiation OncologyRosevilleCaliforniaUnited States95678
    44Kaiser Permanente Downtown CommonsSacramentoCaliforniaUnited States95814
    45University of California Davis Comprehensive Cancer CenterSacramentoCaliforniaUnited States95817
    46Kaiser Permanente-South SacramentoSacramentoCaliforniaUnited States95823
    47South Sacramento Cancer CenterSacramentoCaliforniaUnited States95823
    48Naval Medical Center -San DiegoSan DiegoCaliforniaUnited States92134
    49Kaiser Permanente-San FranciscoSan FranciscoCaliforniaUnited States94115
    50Kaiser Permanente-Santa Teresa-San JoseSan JoseCaliforniaUnited States95119
    51Kaiser Permanente San LeandroSan LeandroCaliforniaUnited States94577
    52Pacific Central Coast Health Center-San Luis ObispoSan Luis ObispoCaliforniaUnited States93401
    53Kaiser San Rafael-GallinasSan RafaelCaliforniaUnited States94903
    54Kaiser Permanente Medical Center - Santa ClaraSanta ClaraCaliforniaUnited States95051
    55Mission Hope Medical Oncology - Santa MariaSanta MariaCaliforniaUnited States93444
    56Kaiser Permanente-Santa RosaSanta RosaCaliforniaUnited States95403
    57Kaiser Permanente Cancer Treatment CenterSouth San FranciscoCaliforniaUnited States94080
    58Kaiser Permanente-South San FranciscoSouth San FranciscoCaliforniaUnited States94080
    59Kaiser Permanente-StocktonStocktonCaliforniaUnited States95210
    60Gene Upshaw Memorial Tahoe Forest Cancer CenterTruckeeCaliforniaUnited States96161
    61Kaiser Permanente Medical Center-VacavilleVacavilleCaliforniaUnited States95688
    62Kaiser Permanente-VallejoVallejoCaliforniaUnited States94589
    63Kaiser Permanente-Walnut CreekWalnut CreekCaliforniaUnited States94596
    64Epic Care Cyberknife CenterWalnut CreekCaliforniaUnited States94597
    65Rocky Mountain Regional VA Medical CenterAuroraColoradoUnited States80045
    66Penrose-Saint Francis HealthcareColorado SpringsColoradoUnited States80907
    67Rocky Mountain Cancer Centers-PenroseColorado SpringsColoradoUnited States80907
    68Saint Francis Cancer CenterColorado SpringsColoradoUnited States80923
    69Kaiser Permanente-FranklinDenverColoradoUnited States80205
    70Porter Adventist HospitalDenverColoradoUnited States80210
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    72Southwest Oncology PCDurangoColoradoUnited States81301
    73Kaiser Permanente-Rock CreekLafayetteColoradoUnited States80026
    74Saint Anthony HospitalLakewoodColoradoUnited States80228
    75Littleton Adventist HospitalLittletonColoradoUnited States80122
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    77Longmont United HospitalLongmontColoradoUnited States80501
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    80Saint Mary Corwin Medical CenterPuebloColoradoUnited States81004
    81Beebe South Coastal Health CampusFrankfordDelawareUnited States19945
    82Beebe Medical CenterLewesDelawareUnited States19958
    83Delaware Clinical and Laboratory Physicians PANewarkDelawareUnited States19713
    84Helen F Graham Cancer CenterNewarkDelawareUnited States19713
    85Medical Oncology Hematology Consultants PANewarkDelawareUnited States19713
    86Christiana Care Health System-Christiana HospitalNewarkDelawareUnited States19718
    87Beebe Health CampusRehoboth BeachDelawareUnited States19971
    88TidalHealth Nanticoke / Allen Cancer CenterSeafordDelawareUnited States19973
    89Christiana Care Health System-Wilmington HospitalWilmingtonDelawareUnited States19801
    90AdventHealth AltamonteAltamonte SpringsFloridaUnited States32701
    91AdventHealth CelebrationCelebrationFloridaUnited States34747
    92UM Sylvester Comprehensive Cancer Center at Coral GablesCoral GablesFloridaUnited States33146
    93UM Sylvester Comprehensive Cancer Center at Deerfield BeachDeerfield BeachFloridaUnited States33442
    94Regional Cancer Center-Lee Memorial Health SystemFort MyersFloridaUnited States33905
    95University of Florida Health Science Center - GainesvilleGainesvilleFloridaUnited States32610
    96UM Sylvester Comprehensive Cancer Center at HollywoodHollywoodFloridaUnited States33021
    97AdventHealth KissimmeeKissimmeeFloridaUnited States34744
    98University of Miami Miller School of Medicine-Sylvester Cancer CenterMiamiFloridaUnited States33136
    99UM Sylvester Comprehensive Cancer Center at KendallMiamiFloridaUnited States33176
    100AdventHealth Medical Group Urology at OrlandoOrlandoFloridaUnited States32803
    101AdventHealth OrlandoOrlandoFloridaUnited States32803
    102Orlando Health Cancer InstituteOrlandoFloridaUnited States32806
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    109Northside HospitalAtlantaGeorgiaUnited States30342
    110Hawaii Cancer Care - Savio'AieaHawaiiUnited States96701
    111Pali Momi Medical Center'AieaHawaiiUnited States96701
    112Queen's Cancer Center - Pearlridge'AieaHawaiiUnited States96701
    113The Cancer Center of Hawaii-Pali Momi'AieaHawaiiUnited States96701
    114Island Urology-HiloHiloHawaiiUnited States96720
    115Hawaii Cancer Care Inc - Waterfront PlazaHonoluluHawaiiUnited States96813
    116Island UrologyHonoluluHawaiiUnited States96813
    117Queen's Cancer Cenrer - POB IHonoluluHawaiiUnited States96813
    118Queen's Medical CenterHonoluluHawaiiUnited States96813
    119Straub Clinic and HospitalHonoluluHawaiiUnited States96813
    120University of Hawaii Cancer CenterHonoluluHawaiiUnited States96813
    121Hawaii Cancer Care Inc-LilihaHonoluluHawaiiUnited States96817
    122Kuakini Medical CenterHonoluluHawaiiUnited States96817
    123Queen's Cancer Center - KuakiniHonoluluHawaiiUnited States96817
    124The Cancer Center of Hawaii-LilihaHonoluluHawaiiUnited States96817
    125Kaiser Permanente Moanalua Medical CenterHonoluluHawaiiUnited States96819
    126Kapiolani Medical Center for Women and ChildrenHonoluluHawaiiUnited States96826
    127Wilcox Memorial Hospital and Kauai Medical ClinicLihueHawaiiUnited States96766
    128Saint Alphonsus Cancer Care Center-BoiseBoiseIdahoUnited States83706
    129Saint Luke's Cancer Institute - BoiseBoiseIdahoUnited States83712
    130Saint Alphonsus Cancer Care Center-CaldwellCaldwellIdahoUnited States83605
    131Kootenai Health - Coeur d'AleneCoeur d'AleneIdahoUnited States83814
    132Walter Knox Memorial HospitalEmmettIdahoUnited States83617
    133Saint Luke's Cancer Institute - FruitlandFruitlandIdahoUnited States83619
    134Idaho Urologic Institute-MeridianMeridianIdahoUnited States83642
    135Saint Luke's Cancer Institute - MeridianMeridianIdahoUnited States83642
    136Saint Alphonsus Medical Center-NampaNampaIdahoUnited States83686
    137Saint Luke's Cancer Institute - NampaNampaIdahoUnited States83686
    138Kootenai Clinic Cancer Services - Post FallsPost FallsIdahoUnited States83854
    139Kootenai Cancer ClinicSandpointIdahoUnited States83864
    140Saint Luke's Cancer Institute - Twin FallsTwin FallsIdahoUnited States83301
    141Saint Anthony's HealthAltonIllinoisUnited States62002
    142Illinois CancerCare-BloomingtonBloomingtonIllinoisUnited States61704
    143Loyola Center for Health at Burr RidgeBurr RidgeIllinoisUnited States60527
    144Illinois CancerCare-CantonCantonIllinoisUnited States61520
    145Memorial Hospital of CarbondaleCarbondaleIllinoisUnited States62902
    146SIH Cancer InstituteCartervilleIllinoisUnited States62918
    147Illinois CancerCare-CarthageCarthageIllinoisUnited States62321
    148Centralia Oncology ClinicCentraliaIllinoisUnited States62801
    149University of IllinoisChicagoIllinoisUnited States60612
    150Cancer Care Specialists of Illinois - DecaturDecaturIllinoisUnited States62526
    151Decatur Memorial HospitalDecaturIllinoisUnited States62526
    152Illinois CancerCare-DixonDixonIllinoisUnited States61021
    153Crossroads Cancer CenterEffinghamIllinoisUnited States62401
    154Illinois CancerCare-EurekaEurekaIllinoisUnited States61530
    155Illinois CancerCare-GalesburgGalesburgIllinoisUnited States61401
    156Western Illinois Cancer Treatment CenterGalesburgIllinoisUnited States61401
    157Loyola Medicine Homer GlenHomer GlenIllinoisUnited States60491
    158Illinois CancerCare-Kewanee ClinicKewaneeIllinoisUnited States61443
    159Illinois CancerCare-MacombMacombIllinoisUnited States61455
    160Loyola University Medical CenterMaywoodIllinoisUnited States60153
    161Marjorie Weinberg Cancer Center at Loyola-GottliebMelrose ParkIllinoisUnited States60160
    162Good Samaritan Regional Health CenterMount VernonIllinoisUnited States62864
    163Cancer Care Center of O'FallonO'FallonIllinoisUnited States62269
    164Illinois CancerCare-Ottawa ClinicOttawaIllinoisUnited States61350
    165Illinois CancerCare-PekinPekinIllinoisUnited States61554
    166Illinois CancerCare-PeoriaPeoriaIllinoisUnited States61615
    167Methodist Medical Center of IllinoisPeoriaIllinoisUnited States61636
    168Illinois CancerCare-PeruPeruIllinoisUnited States61354
    169Valley Radiation OncologyPeruIllinoisUnited States61354
    170Illinois CancerCare-PrincetonPrincetonIllinoisUnited States61356
    171Southern Illinois University School of MedicineSpringfieldIllinoisUnited States62702
    172Springfield ClinicSpringfieldIllinoisUnited States62702
    173Memorial Medical CenterSpringfieldIllinoisUnited States62781
    174Southwest Illinois Health Services LLPSwanseaIllinoisUnited States62226
    175Illinois CancerCare - WashingtonWashingtonIllinoisUnited States61571
    176Indiana University/Melvin and Bren Simon Cancer CenterIndianapolisIndianaUnited States46202
    177Community Cancer Center EastIndianapolisIndianaUnited States46219
    178Community Cancer Center SouthIndianapolisIndianaUnited States46227
    179Community Cancer Center NorthIndianapolisIndianaUnited States46256
    180Springmill Medical CenterIndianapolisIndianaUnited States46290
    181Community Howard Regional HealthKokomoIndianaUnited States46904
    182Reid HealthRichmondIndianaUnited States47374
    183Mary Greeley Medical CenterAmesIowaUnited States50010
    184McFarland Clinic PC - AmesAmesIowaUnited States50010
    185University of Iowa Healthcare Cancer Services Quad CitiesBettendorfIowaUnited States52722
    186McFarland Clinic PC-BooneBooneIowaUnited States50036
    187Saint Anthony Regional HospitalCarrollIowaUnited States51401
    188Medical Oncology and Hematology Associates-West Des MoinesCliveIowaUnited States50325
    189Mercy Cancer Center-West LakesCliveIowaUnited States50325
    190Alegent Health Mercy HospitalCouncil BluffsIowaUnited States51503
    191Greater Regional Medical CenterCrestonIowaUnited States50801
    192Iowa Methodist Medical CenterDes MoinesIowaUnited States50309
    193Medical Oncology and Hematology Associates-Des MoinesDes MoinesIowaUnited States50309
    194Broadlawns Medical CenterDes MoinesIowaUnited States50314
    195Medical Oncology and Hematology Associates-LaurelDes MoinesIowaUnited States50314
    196Mercy Medical Center - Des MoinesDes MoinesIowaUnited States50314
    197Iowa Lutheran HospitalDes MoinesIowaUnited States50316
    198McFarland Clinic PC-Trinity Cancer CenterFort DodgeIowaUnited States50501
    199Trinity Regional Medical CenterFort DodgeIowaUnited States50501
    200University of Iowa/Holden Comprehensive Cancer CenterIowa CityIowaUnited States52242
    201McFarland Clinic PC-JeffersonJeffersonIowaUnited States50129
    202McFarland Clinic PC-MarshalltownMarshalltownIowaUnited States50158
    203Methodist West HospitalWest Des MoinesIowaUnited States50266-7700
    204Mercy Medical Center-West LakesWest Des MoinesIowaUnited States50266
    205Central Care Cancer Center - Garden CityGarden CityKansasUnited States67846
    206Central Care Cancer Center - Great BendGreat BendKansasUnited States67530
    207University of Kansas Cancer Center-WestKansas CityKansasUnited States66112
    208University of Kansas Cancer CenterKansas CityKansasUnited States66160
    209University of Kansas Cancer Center-Overland ParkOverland ParkKansasUnited States66210
    210University of Kansas Hospital-Westwood Cancer CenterWestwoodKansasUnited States66205
    211Flaget Memorial HospitalBardstownKentuckyUnited States40004
    212Commonwealth Cancer Center-CorbinCorbinKentuckyUnited States40701
    213Saint Joseph Radiation Oncology Resource CenterLexingtonKentuckyUnited States40504
    214Saint Joseph Hospital EastLexingtonKentuckyUnited States40509
    215University of Kentucky/Markey Cancer CenterLexingtonKentuckyUnited States40536
    216Saint Joseph LondonLondonKentuckyUnited States40741
    217Jewish HospitalLouisvilleKentuckyUnited States40202
    218The James Graham Brown Cancer Center at University of LouisvilleLouisvilleKentuckyUnited States40202
    219Saints Mary and Elizabeth HospitalLouisvilleKentuckyUnited States40215
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    221Jewish Hospital Medical Center SouthShepherdsvilleKentuckyUnited States40165
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    223Ochsner LSU Health Monroe Medical CenterMonroeLouisianaUnited States71202
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    225Tulane University Health Sciences CenterNew OrleansLouisianaUnited States70112
    226LSU Health Sciences Center at ShreveportShreveportLouisianaUnited States71103
    227Eastern Maine Medical CenterBangorMaineUnited States04401
    228Lafayette Family Cancer Center-EMMCBrewerMaineUnited States04412
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    231Lahey Hospital and Medical CenterBurlingtonMassachusettsUnited States01805
    232Lahey Medical Center-PeabodyPeabodyMassachusettsUnited States01960
    233UMass Memorial Medical Center - University CampusWorcesterMassachusettsUnited States01655
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    235Bronson Battle CreekBattle CreekMichiganUnited States49017
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    239Henry Ford Macomb Hospital-Clinton TownshipClinton TownshipMichiganUnited States48038
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    248Spectrum Health at Butterworth CampusGrand RapidsMichiganUnited States49503
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    293Abbott-Northwestern HospitalMinneapolisMinnesotaUnited States55407
    294Hennepin County Medical CenterMinneapolisMinnesotaUnited States55415
    295Health Partners IncMinneapolisMinnesotaUnited States55454
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    298New Ulm Medical CenterNew UlmMinnesotaUnited States56073
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    300Fairview Northland Medical CenterPrincetonMinnesotaUnited States55371
    301North Memorial Medical Health CenterRobbinsdaleMinnesotaUnited States55422
    302Mayo Clinic in RochesterRochesterMinnesotaUnited States55905
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    304Park Nicollet Clinic - Saint Louis ParkSaint Louis ParkMinnesotaUnited States55416
    305Regions HospitalSaint PaulMinnesotaUnited States55101
    306United HospitalSaint PaulMinnesotaUnited States55102
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    309Lakeview HospitalStillwaterMinnesotaUnited States55082
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    314Minnesota Oncology Hematology PA-WoodburyWoodburyMinnesotaUnited States55125
    315Fairview Lakes Medical CenterWyomingMinnesotaUnited States55092
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    320Cox Cancer Center BransonBransonMissouriUnited States65616
    321Saint Francis Medical CenterCape GirardeauMissouriUnited States63703
    322Southeast Cancer CenterCape GirardeauMissouriUnited States63703
    323Siteman Cancer Center at West County HospitalCreve CoeurMissouriUnited States63141
    324Parkland Health Center - FarmingtonFarmingtonMissouriUnited States63640
    325Capital Region Southwest CampusJefferson CityMissouriUnited States65109
    326Freeman Health SystemJoplinMissouriUnited States64804
    327Mercy Hospital JoplinJoplinMissouriUnited States64804
    328University of Kansas Cancer Center - NorthKansas CityMissouriUnited States64154
    329University of Kansas Cancer Center - Lee's SummitLee's SummitMissouriUnited States64064
    330University of Kansas Cancer Center at North Kansas City HospitalNorth Kansas CityMissouriUnited States64116
    331Delbert Day Cancer Institute at PCRMCRollaMissouriUnited States65401
    332Mercy Clinic-Rolla-Cancer and HematologyRollaMissouriUnited States65401
    333Heartland Regional Medical CenterSaint JosephMissouriUnited States64506
    334Saint Louis Cancer and Breast Institute-South CitySaint LouisMissouriUnited States63109
    335Washington University School of MedicineSaint LouisMissouriUnited States63110
    336Mercy Hospital SouthSaint LouisMissouriUnited States63128
    337Siteman Cancer Center-South CountySaint LouisMissouriUnited States63129
    338Missouri Baptist Medical CenterSaint LouisMissouriUnited States63131
    339Siteman Cancer Center at Christian HospitalSaint LouisMissouriUnited States63136
    340Mercy Hospital Saint LouisSaint LouisMissouriUnited States63141
    341Siteman Cancer Center at Saint Peters HospitalSaint PetersMissouriUnited States63376
    342Sainte Genevieve County Memorial HospitalSainte GenevieveMissouriUnited States63670
    343Mercy Hospital SpringfieldSpringfieldMissouriUnited States65804
    344CoxHealth South HospitalSpringfieldMissouriUnited States65807
    345Missouri Baptist Sullivan HospitalSullivanMissouriUnited States63080
    346Missouri Baptist Outpatient Center-Sunset HillsSunset HillsMissouriUnited States63127
    347Mercy Hospital WashingtonWashingtonMissouriUnited States63090
    348Community Hospital of AnacondaAnacondaMontanaUnited States59711
    349Billings Clinic Cancer CenterBillingsMontanaUnited States59101
    350Bozeman Deaconess HospitalBozemanMontanaUnited States59715
    351Benefis Healthcare- Sletten Cancer InstituteGreat FallsMontanaUnited States59405
    352Great Falls ClinicGreat FallsMontanaUnited States59405
    353Kalispell Regional Medical CenterKalispellMontanaUnited States59901
    354Saint Patrick Hospital - Community HospitalMissoulaMontanaUnited States59802
    355Community Medical HospitalMissoulaMontanaUnited States59804
    356CHI Health Saint FrancisGrand IslandNebraskaUnited States68803
    357CHI Health Good SamaritanKearneyNebraskaUnited States68847
    358Saint Elizabeth Regional Medical CenterLincolnNebraskaUnited States68510
    359Nebraska Methodist HospitalOmahaNebraskaUnited States68114
    360Alegent Health Immanuel Medical CenterOmahaNebraskaUnited States68122
    361Alegent Health Bergan Mercy Medical CenterOmahaNebraskaUnited States68124
    362Alegent Health Lakeside HospitalOmahaNebraskaUnited States68130
    363Creighton University Medical CenterOmahaNebraskaUnited States68131
    364Midlands Community HospitalPapillionNebraskaUnited States68046
    365Cooper Hospital University Medical CenterCamdenNew JerseyUnited States08103
    366The Valley Hospital-Luckow PavilionParamusNew JerseyUnited States07652
    367Neurosurgeons of New Jersey-RidgewoodRidgewoodNew JerseyUnited States07450
    368Valley HospitalRidgewoodNew JerseyUnited States07450
    369Valley Health System-Hematology/OncologyWestwoodNew JerseyUnited States07675
    370University of New Mexico Cancer CenterAlbuquerqueNew MexicoUnited States87102
    371New Mexico Oncology Hematology ConsultantsAlbuquerqueNew MexicoUnited States87109
    372NYP/Weill Cornell Medical CenterNew YorkNew YorkUnited States10065
    373Rochester General HospitalRochesterNew YorkUnited States14621
    374University of RochesterRochesterNew YorkUnited States14642
    375Stony Brook University Medical CenterStony BrookNew YorkUnited States11794
    376AdventHealth Infusion Center AshevilleAshevilleNorth CarolinaUnited States28803
    377UNC Lineberger Comprehensive Cancer CenterChapel HillNorth CarolinaUnited States27599
    378Carolinas Medical Center/Levine Cancer InstituteCharlotteNorth CarolinaUnited States28203
    379Southeastern Medical Oncology Center-ClintonClintonNorth CarolinaUnited States28328
    380AdventHealth Infusion Center HaywoodClydeNorth CarolinaUnited States28721
    381Atrium Health Cabarrus/LCI-ConcordConcordNorth CarolinaUnited States28025
    382Duke University Medical CenterDurhamNorth CarolinaUnited States27710
    383Southeastern Medical Oncology Center-GoldsboroGoldsboroNorth CarolinaUnited States27534
    384AdventHealth HendersonvilleHendersonvilleNorth CarolinaUnited States28792
    385Southeastern Medical Oncology Center-JacksonvilleJacksonvilleNorth CarolinaUnited States28546
    386Vidant Oncology-KenansvilleKenansvilleNorth CarolinaUnited States28349
    387Vidant Oncology-KinstonKinstonNorth CarolinaUnited States28501
    388FirstHealth of the Carolinas-Moore Regional HospitalPinehurstNorth CarolinaUnited States28374
    389Vidant Oncology-RichlandsRichlandsNorth CarolinaUnited States28574
    390AdventHealth Infusion Center WeavervilleWeavervilleNorth CarolinaUnited States28787
    391Wake Forest University Health SciencesWinston-SalemNorth CarolinaUnited States27157
    392Sanford Bismarck Medical CenterBismarckNorth DakotaUnited States58501
    393Essentia Health Cancer Center-South University ClinicFargoNorth DakotaUnited States58103
    394Sanford South University Medical CenterFargoNorth DakotaUnited States58103
    395Southpointe-Sanford Medical Center FargoFargoNorth DakotaUnited States58103
    396Sanford Medical Center FargoFargoNorth DakotaUnited States58104
    397Sanford Broadway Medical CenterFargoNorth DakotaUnited States58122
    398Sanford Roger Maris Cancer CenterFargoNorth DakotaUnited States58122
    399Essentia Health - Jamestown ClinicJamestownNorth DakotaUnited States58401
    400Indu and Raj Soin Medical CenterBeavercreekOhioUnited States45431
    401Strecker Cancer Center-BelpreBelpreOhioUnited States45714
    402Saint Elizabeth Boardman HospitalBoardmanOhioUnited States44512
    403Dayton Physicians LLC-Miami Valley SouthCentervilleOhioUnited States45459
    404Miami Valley Hospital SouthCentervilleOhioUnited States45459
    405Geauga HospitalChardonOhioUnited States44024
    406Adena Regional Medical CenterChillicotheOhioUnited States45601
    407Good Samaritan Hospital - CincinnatiCincinnatiOhioUnited States45220
    408Oncology Hematology Care Inc-KenwoodCincinnatiOhioUnited States45236
    409Bethesda North HospitalCincinnatiOhioUnited States45242
    410TriHealth Cancer Institute-WestsideCincinnatiOhioUnited States45247
    411TriHealth Cancer Institute-AndersonCincinnatiOhioUnited States45255
    412Case Western Reserve UniversityClevelandOhioUnited States44106
    413Cleveland Clinic Cancer Center/Fairview HospitalClevelandOhioUnited States44111
    414Cleveland Clinic FoundationClevelandOhioUnited States44195
    415Ohio State University Comprehensive Cancer CenterColumbusOhioUnited States43210
    416Mount Carmel East HospitalColumbusOhioUnited States43213
    417Columbus Oncology and Hematology Associates IncColumbusOhioUnited States43214
    418Riverside Methodist HospitalColumbusOhioUnited States43214
    419Grant Medical CenterColumbusOhioUnited States43215
    420The Mark H Zangmeister CenterColumbusOhioUnited States43219
    421Mount Carmel Health Center WestColumbusOhioUnited States43222
    422Doctors HospitalColumbusOhioUnited States43228
    423Miami Valley HospitalDaytonOhioUnited States45409
    424Dayton Physician LLC-Miami Valley Hospital NorthDaytonOhioUnited States45415
    425Miami Valley Hospital NorthDaytonOhioUnited States45415
    426Dayton Veterans Affairs Medical CenterDaytonOhioUnited States45428
    427Delaware Health Center-Grady Cancer CenterDelawareOhioUnited States43015
    428Grady Memorial HospitalDelawareOhioUnited States43015
    429Dublin Methodist HospitalDublinOhioUnited States43016
    430Armes Family Cancer CenterFindlayOhioUnited States45840
    431Blanchard Valley HospitalFindlayOhioUnited States45840
    432Orion Cancer CareFindlayOhioUnited States45840
    433Atrium Medical Center-Middletown Regional HospitalFranklinOhioUnited States45005-1066
    434Dayton Physicians LLC-AtriumFranklinOhioUnited States45005
    435Central Ohio Breast and Endocrine SurgeryGahannaOhioUnited States43230
    436Dayton Physicians LLC-WayneGreenvilleOhioUnited States45331
    437Wayne HospitalGreenvilleOhioUnited States45331
    438Mount Carmel Grove City HospitalGrove CityOhioUnited States43123
    439Greater Dayton Cancer CenterKetteringOhioUnited States45409
    440First Dayton Cancer CareKetteringOhioUnited States45420
    441Kettering Medical CenterKetteringOhioUnited States45429
    442Fairfield Medical CenterLancasterOhioUnited States43130
    443Saint Rita's Medical CenterLimaOhioUnited States45801
    444OhioHealth Mansfield HospitalMansfieldOhioUnited States44903
    445Cleveland Clinic Cancer Center MansfieldMansfieldOhioUnited States44906
    446Marietta Memorial HospitalMariettaOhioUnited States45750
    447OhioHealth Marion General HospitalMarionOhioUnited States43302
    448Hillcrest Hospital Cancer CenterMayfield HeightsOhioUnited States44124
    449UH Seidman Cancer Center at Landerbrook Health CenterMayfield HeightsOhioUnited States44124
    450Knox Community HospitalMount VernonOhioUnited States43050
    451Licking Memorial HospitalNewarkOhioUnited States43055
    452Newark Radiation OncologyNewarkOhioUnited States43055
    453Mercy Health Perrysburg Cancer CenterPerrysburgOhioUnited States43551
    454Southern Ohio Medical CenterPortsmouthOhioUnited States45662
    455North Coast Cancer CareSanduskyOhioUnited States44870
    456UH Seidman Cancer Center at Firelands Regional Medical CenterSanduskyOhioUnited States44870
    457Springfield Regional Cancer CenterSpringfieldOhioUnited States45504
    458Springfield Regional Medical CenterSpringfieldOhioUnited States45505
    459Cleveland Clinic Cancer Center StrongsvilleStrongsvilleOhioUnited States44136
    460Saint Vincent Mercy Medical CenterToledoOhioUnited States43608
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    462Dayton Physicians LLC-Upper ValleyTroyOhioUnited States45373
    463Upper Valley Medical CenterTroyOhioUnited States45373
    464South Pointe HospitalWarrensville HeightsOhioUnited States44122
    465Saint Joseph Warren HospitalWarrenOhioUnited States44484
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    467UH Seidman Cancer Center at Saint John Medical CenterWestlakeOhioUnited States44145
    468Cleveland Clinic Wooster Family Health and Surgery CenterWoosterOhioUnited States44691
    469Wright-Patterson Medical CenterWright-Patterson Air Force BaseOhioUnited States45433
    470Saint Elizabeth Youngstown HospitalYoungstownOhioUnited States44501
    471Genesis Healthcare System Cancer Care CenterZanesvilleOhioUnited States43701
    472Cancer Centers of Southwest Oklahoma ResearchLawtonOklahomaUnited States73505
    473University of Oklahoma Health Sciences CenterOklahoma CityOklahomaUnited States73104
    474Mercy Hospital Oklahoma CityOklahoma CityOklahomaUnited States73120
    475Oklahoma Cancer Specialists and Research Institute-TulsaTulsaOklahomaUnited States74146
    476Saint Alphonsus Medical Center-Baker CityBaker CityOregonUnited States97814
    477Saint Charles Health SystemBendOregonUnited States97701
    478Clackamas Radiation Oncology CenterClackamasOregonUnited States97015
    479Providence Cancer Institute Clackamas ClinicClackamasOregonUnited States97015
    480Bay Area HospitalCoos BayOregonUnited States97420
    481Three Rivers Community HospitalGrants PassOregonUnited States97527
    482Rogue Valley Medical CenterMedfordOregonUnited States97504
    483Providence Newberg Medical CenterNewbergOregonUnited States97132
    484Saint Alphonsus Medical Center-OntarioOntarioOregonUnited States97914
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    486Providence Portland Medical CenterPortlandOregonUnited States97213
    487Providence Saint Vincent Medical CenterPortlandOregonUnited States97225
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    494Penn State Milton S Hershey Medical CenterHersheyPennsylvaniaUnited States17033-0850
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    496Geisinger Wyoming Valley/Henry Cancer CenterWilkes-BarrePennsylvaniaUnited States18711
    497Ralph H Johnson VA Medical CenterCharlestonSouth CarolinaUnited States29401
    498Medical University of South CarolinaCharlestonSouth CarolinaUnited States29425
    499McLeod Regional Medical CenterFlorenceSouth CarolinaUnited States29506
    500Saint Francis HospitalGreenvilleSouth CarolinaUnited States29601
    501Saint Francis Cancer CenterGreenvilleSouth CarolinaUnited States29607
    502Avera Cancer InstituteSioux FallsSouth DakotaUnited States57105
    503Saint Joseph Regional Cancer CenterBryanTexasUnited States77802
    504M D Anderson Cancer CenterHoustonTexasUnited States77030
    505Huntsman Cancer Institute/University of UtahSalt Lake CityUtahUnited States84112
    506Virginia Commonwealth University/Massey Cancer CenterRichmondVirginiaUnited States23298
    507Providence Regional Cancer System-AberdeenAberdeenWashingtonUnited States98520
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    509Harrison HealthPartners Hematology and Oncology-BremertonBremertonWashingtonUnited States98310
    510Harrison Medical CenterBremertonWashingtonUnited States98310
    511Highline Medical Center-Main CampusBurienWashingtonUnited States98166
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    513Swedish Cancer Institute-EdmondsEdmondsWashingtonUnited States98026
    514Saint Elizabeth HospitalEnumclawWashingtonUnited States98022
    515Providence Regional Cancer PartnershipEverettWashingtonUnited States98201
    516Saint Francis HospitalFederal WayWashingtonUnited States98003
    517Swedish Cancer Institute-IssaquahIssaquahWashingtonUnited States98029
    518Kadlec Clinic Hematology and OncologyKennewickWashingtonUnited States99336
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    520Saint Clare HospitalLakewoodWashingtonUnited States98499
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    523Pacific Gynecology SpecialistsSeattleWashingtonUnited States98104
    524Swedish Medical Center-Ballard CampusSeattleWashingtonUnited States98107
    525Swedish Medical Center-First HillSeattleWashingtonUnited States98122-4307
    526Swedish Medical Center-Cherry HillSeattleWashingtonUnited States98122-5711
    527PeaceHealth United General Medical CenterSedro-WoolleyWashingtonUnited States98284
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    529Franciscan Research Center-Northwest Medical PlazaTacomaWashingtonUnited States98405
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    531PeaceHealth Southwest Medical CenterVancouverWashingtonUnited States98664
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    533Providence Regional Cancer System-YelmYelmWashingtonUnited States98597
    534United Hospital CenterBridgeportWest VirginiaUnited States26330
    535WVUH-Berkely Medical CenterMartinsburgWest VirginiaUnited States25401
    536West Virginia University HealthcareMorgantownWest VirginiaUnited States26506
    537Camden Clark Medical CenterParkersburgWest VirginiaUnited States26101
    538ThedaCare Regional Cancer CenterAppletonWisconsinUnited States54911
    539Duluth Clinic AshlandAshlandWisconsinUnited States54806
    540Northwest Wisconsin Cancer CenterAshlandWisconsinUnited States54806
    541Aurora Cancer Care-Southern Lakes VLCCBurlingtonWisconsinUnited States53105
    542Aurora Saint Luke's South ShoreCudahyWisconsinUnited States53110
    543Marshfield Medical Center-EC Cancer CenterEau ClaireWisconsinUnited States54701
    544Mayo Clinic Health System-Eau Claire ClinicEau ClaireWisconsinUnited States54701
    545Mayo Clinic Health System Eau Claire Hospital-Luther CampusEau ClaireWisconsinUnited States54703
    546Aurora Health Care Germantown Health CenterGermantownWisconsinUnited States53022
    547Aurora Cancer Care-GraftonGraftonWisconsinUnited States53024
    548Bellin Memorial HospitalGreen BayWisconsinUnited States54301
    549Saint Vincent Hospital Cancer Center Green BayGreen BayWisconsinUnited States54301
    550Saint Vincent Hospital Cancer Center at Saint Mary'sGreen BayWisconsinUnited States54303
    551Aurora BayCare Medical CenterGreen BayWisconsinUnited States54311
    552Aurora Cancer Care-Kenosha SouthKenoshaWisconsinUnited States53142
    553Gundersen Lutheran Medical CenterLa CrosseWisconsinUnited States54601
    554University of Wisconsin Hospital and ClinicsMadisonWisconsinUnited States53792
    555Aurora Bay Area Medical Group-MarinetteMarinetteWisconsinUnited States54143
    556Marshfield Medical Center-MarshfieldMarshfieldWisconsinUnited States54449
    557Aurora Cancer Care-MilwaukeeMilwaukeeWisconsinUnited States53209
    558Aurora Saint Luke's Medical CenterMilwaukeeWisconsinUnited States53215
    559Medical College of WisconsinMilwaukeeWisconsinUnited States53226
    560Aurora Sinai Medical CenterMilwaukeeWisconsinUnited States53233
    561Marshfield Clinic-Minocqua CenterMinocquaWisconsinUnited States54548
    562ProHealth D N Greenwald CenterMukwonagoWisconsinUnited States53149
    563Froedtert and MCW Moorland Reserve Health CenterNew BerlinWisconsinUnited States53151
    564Cancer Center of Western WisconsinNew RichmondWisconsinUnited States54017
    565ProHealth Oconomowoc Memorial HospitalOconomowocWisconsinUnited States53066
    566Saint Vincent Hospital Cancer Center at Oconto FallsOconto FallsWisconsinUnited States54154
    567Vince Lombardi Cancer Clinic - OshkoshOshkoshWisconsinUnited States54904
    568Aurora Cancer Care-RacineRacineWisconsinUnited States53406
    569Marshfield Medical Center-Rice LakeRice LakeWisconsinUnited States54868
    570Vince Lombardi Cancer Clinic-SheboyganSheboyganWisconsinUnited States53081
    571Marshfield Clinic Stevens Point CenterStevens PointWisconsinUnited States54482
    572Saint Vincent Hospital Cancer Center at Sturgeon BaySturgeon BayWisconsinUnited States54235-1495
    573Aurora Medical Center in SummitSummitWisconsinUnited States53066
    574Vince Lombardi Cancer Clinic-Two RiversTwo RiversWisconsinUnited States54241
    575ProHealth Waukesha Memorial HospitalWaukeshaWisconsinUnited States53188
    576UW Cancer Center at ProHealth CareWaukeshaWisconsinUnited States53188
    577ThedaCare Cancer Care - WaupacaWaupacaWisconsinUnited States54981
    578Aurora Cancer Care-Milwaukee WestWauwatosaWisconsinUnited States53226
    579Aurora West Allis Medical CenterWest AllisWisconsinUnited States53227
    580Marshfield Medical Center - WestonWestonWisconsinUnited States54476
    581Billings Clinic-CodyCodyWyomingUnited States82414
    582Welch Cancer CenterSheridanWyomingUnited States82801

    Sponsors and Collaborators

    • Southwest Oncology Group
    • National Cancer Institute (NCI)
    • Janssen, LP
    • Adaptive


    • Principal Investigator: Amrita Krishnan, MD, FACP, City of Hope Medical Center
    • Principal Investigator: Parameswaran Hari, MD, Medical College of Wisconsin

    Study Documents (Full-Text)

    None provided.

    More Information


    None provided.
    Responsible Party:
    Southwest Oncology Group
    ClinicalTrials.gov Identifier:
    Other Study ID Numbers:
    • S1803
    • U10CA180888
    • NCI-2018-02465
    First Posted:
    Aug 28, 2019
    Last Update Posted:
    Nov 9, 2021
    Last Verified:
    Nov 1, 2021
    Individual Participant Data (IPD) Sharing Statement:
    Plan to Share IPD:
    Studies a U.S. FDA-regulated Drug Product:
    Studies a U.S. FDA-regulated Device Product:
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Nov 9, 2021