DRAMMATIC: S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration

Sponsor
Southwest Oncology Group (Other)
Overall Status
Recruiting
CT.gov ID
NCT04071457
Collaborator
National Cancer Institute (NCI) (NIH), Janssen, LP (Industry), Adaptive (Other)
1,100
582
7
252.2
1.9
0

Study Details

Study Description

Brief Summary

Patients are enrolled to screening (Reg Step 1) prior to or after ASCT but prior to Reg Step 2. Patients are followed until they will begin Maintenance and then registered to Reg Step 2 (first randomization). Patients are randomized between Lenalidomide for 2 years and Lenalidomide + Daratumumab/rHuPH20. After 2 years of Maintenance, MRD is assessed to guide further therapy. MRD-positive patients will continue with the assigned treatment. MRD-negative patients will be further randomized (Reg Step 3) to either continue or discontinue the assigned treatment. Patients are treated for up to 7 years from Step 2 reg and followed for up to 15 years.

Condition or Disease Intervention/Treatment Phase
Phase 3

Study Design

Study Type:
Interventional
Anticipated Enrollment :
1100 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
S1803, Phase III Study of Daratumumab/rHuPH20 (NSC-810307) + Lenalidomide or Lenalidomide as Post-Autologous Stem Cell Transplant Maintenance Therapy in Patients With Multiple Myeloma (MM) Using Minimal Residual Disease to Direct Therapy Duration (DRAMMATIC Study)
Actual Study Start Date :
Jun 27, 2019
Anticipated Primary Completion Date :
Jul 1, 2029
Anticipated Study Completion Date :
Jul 1, 2040

Arms and Interventions

Arm Intervention/Treatment
No Intervention: Study Entry / Screening

Study entry/screening to follow patient until Maintenance.

Active Comparator: Arm 1: Lenalidomide

Lenalidomide 10 mg/day, D1-28, q28 days for 3 cycles, then 15 mg/day, D1-28 for up to 2 years from starting treatment.

Drug: Lenalidomide
Commercially available intervention
Other Names:
  • CC-5013
  • Revlimid
  • Experimental: Arm 2: Lenalidomide + Daratumumab/rHuPH20

    Lenalidomide 10 mg/day, D1-28, q28 days for 3 cycles, then 15 mg/day, D1-28 for up to 2 years from starting treatment. Plus Daratumumab/rHuPH20 1800 mg/30,000 units D1, 8, 15, 22 q 28 days for 2 cycles, then D 1 and 15 q 28 days for cycles 3-6 then D1 q 28 days for subsequent cycles for up to 2 years from starting treatment.

    Drug: Lenalidomide
    Commercially available intervention
    Other Names:
  • CC-5013
  • Revlimid
  • Drug: Daratumumab/rHuPH20
    SWOG-Held IND

    Active Comparator: Arm 1a: Continue Lenalidomide

    MRD+ or MRD- and randomized to Arm 1a: Lenalidomide 10 mg/day, D1-28, q28 days for 3 cycles, then 15 mg/day, D1-28 for up to 7 years from starting treatment.

    Drug: Lenalidomide
    Commercially available intervention
    Other Names:
  • CC-5013
  • Revlimid
  • No Intervention: Arm 1b: Stop Lenalidomide

    MRD- and randomized to Arm 1b: Discontinue protocol therapy.

    Active Comparator: Arm 2a: Continue Lenalidomide + Daratumumab/rHuPH20

    MRD+ or MRD- and randomized to Arm 2a: Lenalidomide 10 mg/day, D1-28, q28 days for 3 cycles, then 15 mg/day, D1-28 for up to 7 years from starting treatment. Plus Daratumumab/rHuPH20 1800 mg/30,000 units D1, 8, 15, 22 q 28 days for 2 cycles, then D 1 and 15 q 28 days for cycles 3-6 then D1 q 28 days for subsequent cycles for up to 7 years from starting treatment.

    Drug: Lenalidomide
    Commercially available intervention
    Other Names:
  • CC-5013
  • Revlimid
  • Drug: Daratumumab/rHuPH20
    SWOG-Held IND

    No Intervention: Arm 2b: Stop Lenalidomide + Daratumumab/rHuPH20

    MRD- and randomized to Arm 2b: Discontinue protocol therapy.

    Outcome Measures

    Primary Outcome Measures

    1. Overall Survival [From date of intial randomization until death due to any cause, assessed up to 15 years]

      Overall survival will evaluated using a weighted log-rank test and will be compared between primary treatment arms. All eligible patients with valid consent will be included in the analysis. Patients last known to be alive are censored at the date of last contact.

    Secondary Outcome Measures

    1. Progression Free Survival [From date of intial randomization until progression or death due to any cause, whichever occurs first, assessed up to 7 years]

      Progression-free survival will evaluated using a weighted log-rank test and will be compared between primary treatment arms. All eligible patients with valid consent will be included in the analysis. Patients last known to be progression-free and alive are censored at the date of last contact.

    2. Response (PR or better) [From date of initial randomization until date of best response while on study treatment.]

      Per International Uniform Response Criteria for Multiple Myeloma PR- ≥ 50% reduction in size of soft tissue plasmacytomas & plasma cells; ≥ 50% decrease in serum & reduction in urine M protein ≥ 90% or to < 200 mg/24hr or ≥ 50% decrease in difference in uninvolved & involved serum free light chain levels; VGPR- PR + Serum and urine M proteins detectable by immunofixation but not on electrophoresis or ≥ 90% reduction in serum M protein & urine M protein < 100 mg/24 hrs; uPR- 1 objective status of PR, but confirmation studies are not done, or do not meet the requirements necessary to confirm response; SD- does not meet criteria for sCR, CR, VGPR, PR or PROG; PROG- new or increase in size of existing bone lesions or soft tissue plasmacytomas/ development of hypercalcemia attributable solely to MM/ ≥ 25% increase from baseline/ lowest response level of either serum or Urine M protein, difference in involved & uninvolved serum free light chain level or bone marrow plasma cell percentage.

    3. MRD Negativity [24 months from initial randomization]

      The rate of MRD response will be calculated as the number of patients who achieved MRD response divided by the number of eligible patients; patients without a conclusive MRD results will be included as non-responders. Comparisons between arms will be made using a stratified Cochran-Mantel-Haenszel test. MRD data will be collected from the central testing laboratory, including percent of cells detected and total cells collected. Unless the sample is limiting, 5 x 106 events are collected for a standard multiple myeloma MRD sensitivities of 0.0001%. MRD negativity will be defined as no templates observed at a sensitivity of 1 in a million cells assessed, with a minimum of 1 million cells being assessed. MRD positivity will be defined as any templates observed regardless of the number of cells analyzed, or non-diagnostic specimens, including if the reference specimen from diagnosis is not able to be sequenced.

    Other Outcome Measures

    1. Toxicity assessment [From the time of intial randomization for up to 7 years.]

      All randomized patients that have initiated treatment will be considered evaluable for toxicity analyses. The maximum Grade for each toxicity will be recorded for each patient, and frequency tables will be reviewed to determine toxicity patterns.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 75 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No

    Registration Step 1 Except where otherwise indicated below that test is required in a shorter timeframe, all tests for establishing baseline disease status must be completed within 60 days prior to registration. All test results must be documented on the Baseline Tumor Assessment Form for Multiple Myeloma and the Onstudy Form.

    Inclusion Criteria

    • Patients must have had a confirmed diagnosis of symptomatic multiple myeloma (See Section 4.1) that required systemic induction therapy prior to autologous stem cell transplantation (ASCT).

    • Patients with disease measurable by serum light chain assay alone are eligible (defined as >/= 100 mg/L on involved light chain).

    • Patients must be registered to Step 1 prior to registration to Step 2. Registration to Step 1 may take place prior to or after autologous stem cell transplant (ASCT), but after completion of induction therapy.

    • Patients must have initiated induction therapy within 12 months prior to registration Step 1 and have received at least two cycles of induction therapy.

    • Patients must be willing and able to take DVT prophylaxis (aspirin, low molecular weight heparin, warfarin, or equivalent oral anticoagulation).

    • Patients must be >/= 18 and </= 75 years of age at time of registration to Step 1.

    • Patients must have history and physical exam within 28 days prior to registration.

    • Patients must have Zubrod Performance Status </= 2.

    • Patients must have evidence of adequate renal function, as defined by (1) creatinine clearance (CrCl) >/= 30 mL/min., as measured by a 24-hour urine collection, or estimated by the Cockcroft and Gault formula, or (2) serum creatinine < 2.5 mg/dL. Values must be obtained within 28 days prior to registration.

    • Patients must have adequate hepatic function defined by the following within 42 days prior to registration:

    • Total bilirubin </=1.5 x IULN (institutional upper limit of the norm) AND

    • AST and ALT </=3.0 x IULN

    • Patients must meet one of the following criteria:

    • Be acceptable for transplant per institutional guidelines and the criteria evidencing this must be documented on the S1803 Onstudy Form. (See Appendix 18.3 for standard transplant eligibility guidelines. Note that these are guidelines and not required criteria.) OR

    • Have completed autologous stem cell transplant within 180 days prior to registration (see also Section 5.2a).

    • Patient's with human immunodeficiency virus (HIV) are eligible providing they are on effective antiretroviral therapy and have undetectable viral load at their most previous viral load test and within 6 months prior to registration.

    • Patients must be able to take and swallow oral medication (capsules) whole. Patients may not have any known impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of study drug (e.g. ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, or small bowel resection).

    • For patients who have not yet received transplant: Patients must be willing and able to return to the transplant center for their assigned treatment after randomization. Note that patients need not have a direct relationship with the transplant center in order to register.

    • Patients must submit specimens for MRD as outlined in Section 15.1. See Section 15.1 for further information, including specimen submission timepoints. Note that patients are not ineligible based solely on archival specimens being unavailable.

    • Patients must be offered participation in specimen banking for future research. With patient's consent, specimens must be submitted as outlined in Section 15.2.

    • Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.

    • As a part of the OPEN registration process (see Section 13.3 for OPEN access instructions) the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system.

    Exclusion Criteria

    • Patients with smoldering myeloma are not eligible. Patients with purely non-secretory MM as measured by electrophoresis and immunofixation and the absence of Bence Jones proteins in the urine are not eligible. Patients must have measurable M protein in the serum (defined as >/= 0.5g/dL) or urine (defined as >/= 200 mg/24h). Patients with plasma cell leukemia are not eligible.

    • Patients must not have any organ involvement by amyloidosis or evidence of amyloidosis related organ dysfunction.

    • Patients must not have progressive disease at any time prior to registration.

    • Patients must not be refractory to either lenalidomide or daratumumab/rHuPH20.

    • Patients must not be intolerant to either lenalidomide or daratumumab/rHuPH20.

    • Patients must not have received any investigational agents within 14 days prior to registration.

    • Patients must not have chronic obstructive pulmonary disease with a forced expiratory volume in 1 second (FEV1) < 50% of predicted normal. FEV1 is required for patients suspected of having chronic obstructive pulmonary disease and are not eligible if FEV1 is < 50% of predicted normal.

    • Patients must not have moderate or severe persistent asthma within the past 2 years and must not have currently uncontrolled asthma of any classification.

    • Patients must not have had prior autograft or allograft, or prior organ transplant requiring immunosuppressive therapy.

    • Patients must not have known allergy to any of the study drugs.

    • Patients with uncontrolled bacterial, viral or fungal infections (currently taking medication and with progression or no clinical improvement) at time of enrollment are not eligible.

    • Patients must not have known central nervous system (CNS) involvement with multiple myeloma, defined as CSF positivity for plasma cells at any time or a parenchymal CNS plasmacytoma at time of enrollment. Lumbar puncture is not required.

    • Patients must not be seropositive for hepatitis C (except in the setting of sustained virologic response, defined as undetectable viral load at least 12 weeks after completion of antiviral therapy). HCV testing is only required if clinically indicated or if the patient has a history of HCV.

    • No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated Stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for three years.

    • Patients must not have any uncontrolled intercurrent illness including (not limited to): Symptomatic CHF (NYHA III/IV), unstable angina pectoris or coronary angioplasty, or stenting within 6 months prior to registration, Unstable cardiac arrhythmia (ongoing cardiac dysrhythmias of NCI CTCAE v5.0 Grade >/= 2), intra-cardiac defibrillators, known cardiac metastases, or abnormal cardiac valve morphology (>/= Grade 3), or known psychiatric illness that would limit study compliance.

    Registration Step 2 - First Randomization (Post-ASCT, Pre-Maintenance)

    Inclusion Criteria:
    • Patients must have completed ASCT within 180 days prior to registering to Step 2.

    • Patients must have one of the following performed within 60 days prior to registration for disease assessment: diagnostic quality skeletal survey, whole body CT scan, MRI, or PET.

    • Patients must have Zubrod Performance Status </= 2

    • Patients must have adequate bone marrow function as evidenced by platelets >/= 75,000/mm3 and ANC >/= 1,000/mm3 within 28 days prior to first randomization:

    • Patients must have adequate hepatic function defined by the following within 28 days prior to first randomization:

    • Total bilirubin </=1.5 x IULN (institutional upper limit of the norm) AND AST and ALT </=3.0 x IULN

    • Patients must have evidence of adequate renal function, as defined by creatinine clearance (CrCl) >/= 30 mL/min., as measured by a 24-hour urine collection, or estimated by the Cockcroft and Gault formula, or have a serum creatinine < 2.5 mg/dL within 28 days prior to first randomization.

    • All ASCT-related toxicities must have recovered to </=Grade 1 (except for alopecia, fatigue and amenorrhea) prior to first randomization.

    • Mucositis and gastrointestinal symptoms must have resolved to </=Grade 1.

    • Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10-14 days prior to registration.

    • FCBP must agree to have a second pregnancy test within 24 hours prior to starting Cycle 1. Further, FCBP must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control: one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before starting lenalidomide. FCBP must also agree to ongoing pregnancy testing and must agree to not become pregnant for at least 3 months after the last dose of study treatment.

    • Men must agree to use a latex condom during sexual contact with a FCBP, even if they have had a successful vasectomy, during the study treatment and for 3 months after the last dose of study treatment.

    • Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.

    Exclusion Criteria:
    • Patients must not have received any other maintenance therapy post-ASCT and prior to Step 2 registration.

    • Patients must not have had progressive disease between induction and registration to Registration Step 2. (See Section 10.1b).

    Registration Step 3 - Second Randomization (Post 24 Months Maintenance)

    Inclusion Criteria:
    • Patients must have completed 24 cycles of protocol maintenance with either lenalidomide or lenalidomide + daratumumab/rHuPH20.

    • Patients must have 24-month MRD by NGS test results available and must be MRD negative. Patients whose PCR results are indeterminable will be considered to have positive results.

    • Patients must be in very good partial remission (VGPR) or better by IMWG response criteria (see Section 10.1b).

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Anchorage Associates in Radiation Medicine Anchorage Alaska United States 98508
    2 Anchorage Radiation Therapy Center Anchorage Alaska United States 99504
    3 Alaska Breast Care and Surgery LLC Anchorage Alaska United States 99508
    4 Alaska Oncology and Hematology LLC Anchorage Alaska United States 99508
    5 Alaska Women's Cancer Care Anchorage Alaska United States 99508
    6 Anchorage Oncology Centre Anchorage Alaska United States 99508
    7 Katmai Oncology Group Anchorage Alaska United States 99508
    8 Providence Alaska Medical Center Anchorage Alaska United States 99508
    9 Cancer Center at Saint Joseph's Phoenix Arizona United States 85004
    10 University of Arizona Cancer Center-Orange Grove Campus Tucson Arizona United States 85704
    11 Banner University Medical Center - Tucson Tucson Arizona United States 85719
    12 University of Arizona Cancer Center-North Campus Tucson Arizona United States 85719
    13 Mercy Hospital Fort Smith Fort Smith Arkansas United States 72903
    14 CHI Saint Vincent Cancer Center Hot Springs Hot Springs Arkansas United States 71913
    15 University of Arkansas for Medical Sciences Little Rock Arkansas United States 72205
    16 Kaiser Permanente-Deer Valley Medical Center Antioch California United States 94531
    17 Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande California United States 93420
    18 Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California United States 91505
    19 City of Hope Comprehensive Cancer Center Duarte California United States 91010
    20 Epic Care-Dublin Dublin California United States 94568
    21 Kaiser Permanente Dublin Dublin California United States 94568
    22 Bay Area Breast Surgeons Inc Emeryville California United States 94608
    23 Epic Care Partners in Cancer Care Emeryville California United States 94608
    24 Kaiser Permanente-Fremont Fremont California United States 94538
    25 Fresno Cancer Center Fresno California United States 93720
    26 Kaiser Permanente-Fresno Fresno California United States 93720
    27 Cedars Sinai Medical Center Los Angeles California United States 90048
    28 Contra Costa Regional Medical Center Martinez California United States 94553-3156
    29 Fremont - Rideout Cancer Center Marysville California United States 95901
    30 Kaiser Permanente-Modesto Modesto California United States 95356
    31 Alta Bates Summit Medical Center - Summit Campus Oakland California United States 94609
    32 Bay Area Tumor Institute Oakland California United States 94609
    33 Kaiser Permanente Oakland-Broadway Oakland California United States 94611
    34 Kaiser Permanente-Oakland Oakland California United States 94611
    35 UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California United States 92868
    36 Desert Regional Medical Center Palm Springs California United States 92262
    37 Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cordova California United States 95670
    38 Kaiser Permanente- Marshall Medical Offices Redwood City California United States 94063
    39 Kaiser Permanente-Redwood City Redwood City California United States 94063
    40 Kaiser Permanente-Richmond Richmond California United States 94801
    41 Rohnert Park Cancer Center Rohnert Park California United States 94928
    42 Kaiser Permanente-Roseville Roseville California United States 95661
    43 The Permanente Medical Group-Roseville Radiation Oncology Roseville California United States 95678
    44 Kaiser Permanente Downtown Commons Sacramento California United States 95814
    45 University of California Davis Comprehensive Cancer Center Sacramento California United States 95817
    46 Kaiser Permanente-South Sacramento Sacramento California United States 95823
    47 South Sacramento Cancer Center Sacramento California United States 95823
    48 Naval Medical Center -San Diego San Diego California United States 92134
    49 Kaiser Permanente-San Francisco San Francisco California United States 94115
    50 Kaiser Permanente-Santa Teresa-San Jose San Jose California United States 95119
    51 Kaiser Permanente San Leandro San Leandro California United States 94577
    52 Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo California United States 93401
    53 Kaiser San Rafael-Gallinas San Rafael California United States 94903
    54 Kaiser Permanente Medical Center - Santa Clara Santa Clara California United States 95051
    55 Mission Hope Medical Oncology - Santa Maria Santa Maria California United States 93444
    56 Kaiser Permanente-Santa Rosa Santa Rosa California United States 95403
    57 Kaiser Permanente Cancer Treatment Center South San Francisco California United States 94080
    58 Kaiser Permanente-South San Francisco South San Francisco California United States 94080
    59 Kaiser Permanente-Stockton Stockton California United States 95210
    60 Gene Upshaw Memorial Tahoe Forest Cancer Center Truckee California United States 96161
    61 Kaiser Permanente Medical Center-Vacaville Vacaville California United States 95688
    62 Kaiser Permanente-Vallejo Vallejo California United States 94589
    63 Kaiser Permanente-Walnut Creek Walnut Creek California United States 94596
    64 Epic Care Cyberknife Center Walnut Creek California United States 94597
    65 Rocky Mountain Regional VA Medical Center Aurora Colorado United States 80045
    66 Penrose-Saint Francis Healthcare Colorado Springs Colorado United States 80907
    67 Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado United States 80907
    68 Saint Francis Cancer Center Colorado Springs Colorado United States 80923
    69 Kaiser Permanente-Franklin Denver Colorado United States 80205
    70 Porter Adventist Hospital Denver Colorado United States 80210
    71 Mercy Medical Center Durango Colorado United States 81301
    72 Southwest Oncology PC Durango Colorado United States 81301
    73 Kaiser Permanente-Rock Creek Lafayette Colorado United States 80026
    74 Saint Anthony Hospital Lakewood Colorado United States 80228
    75 Littleton Adventist Hospital Littleton Colorado United States 80122
    76 Kaiser Permanente-Lone Tree Lone Tree Colorado United States 80124
    77 Longmont United Hospital Longmont Colorado United States 80501
    78 Rocky Mountain Cancer Centers-Longmont Longmont Colorado United States 80501
    79 Parker Adventist Hospital Parker Colorado United States 80138
    80 Saint Mary Corwin Medical Center Pueblo Colorado United States 81004
    81 Beebe South Coastal Health Campus Frankford Delaware United States 19945
    82 Beebe Medical Center Lewes Delaware United States 19958
    83 Delaware Clinical and Laboratory Physicians PA Newark Delaware United States 19713
    84 Helen F Graham Cancer Center Newark Delaware United States 19713
    85 Medical Oncology Hematology Consultants PA Newark Delaware United States 19713
    86 Christiana Care Health System-Christiana Hospital Newark Delaware United States 19718
    87 Beebe Health Campus Rehoboth Beach Delaware United States 19971
    88 TidalHealth Nanticoke / Allen Cancer Center Seaford Delaware United States 19973
    89 Christiana Care Health System-Wilmington Hospital Wilmington Delaware United States 19801
    90 AdventHealth Altamonte Altamonte Springs Florida United States 32701
    91 AdventHealth Celebration Celebration Florida United States 34747
    92 UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida United States 33146
    93 UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida United States 33442
    94 Regional Cancer Center-Lee Memorial Health System Fort Myers Florida United States 33905
    95 University of Florida Health Science Center - Gainesville Gainesville Florida United States 32610
    96 UM Sylvester Comprehensive Cancer Center at Hollywood Hollywood Florida United States 33021
    97 AdventHealth Kissimmee Kissimmee Florida United States 34744
    98 University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida United States 33136
    99 UM Sylvester Comprehensive Cancer Center at Kendall Miami Florida United States 33176
    100 AdventHealth Medical Group Urology at Orlando Orlando Florida United States 32803
    101 AdventHealth Orlando Orlando Florida United States 32803
    102 Orlando Health Cancer Institute Orlando Florida United States 32806
    103 AdventHealth East Orlando Orlando Florida United States 32822
    104 UM Sylvester Comprehensive Cancer Center at Plantation Plantation Florida United States 33324
    105 Moffitt Cancer Center-International Plaza Tampa Florida United States 33607
    106 Moffitt Cancer Center - McKinley Campus Tampa Florida United States 33612
    107 Moffitt Cancer Center Tampa Florida United States 33612
    108 AdventHealth Winter Park Winter Park Florida United States 32792
    109 Northside Hospital Atlanta Georgia United States 30342
    110 Hawaii Cancer Care - Savio 'Aiea Hawaii United States 96701
    111 Pali Momi Medical Center 'Aiea Hawaii United States 96701
    112 Queen's Cancer Center - Pearlridge 'Aiea Hawaii United States 96701
    113 The Cancer Center of Hawaii-Pali Momi 'Aiea Hawaii United States 96701
    114 Island Urology-Hilo Hilo Hawaii United States 96720
    115 Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii United States 96813
    116 Island Urology Honolulu Hawaii United States 96813
    117 Queen's Cancer Cenrer - POB I Honolulu Hawaii United States 96813
    118 Queen's Medical Center Honolulu Hawaii United States 96813
    119 Straub Clinic and Hospital Honolulu Hawaii United States 96813
    120 University of Hawaii Cancer Center Honolulu Hawaii United States 96813
    121 Hawaii Cancer Care Inc-Liliha Honolulu Hawaii United States 96817
    122 Kuakini Medical Center Honolulu Hawaii United States 96817
    123 Queen's Cancer Center - Kuakini Honolulu Hawaii United States 96817
    124 The Cancer Center of Hawaii-Liliha Honolulu Hawaii United States 96817
    125 Kaiser Permanente Moanalua Medical Center Honolulu Hawaii United States 96819
    126 Kapiolani Medical Center for Women and Children Honolulu Hawaii United States 96826
    127 Wilcox Memorial Hospital and Kauai Medical Clinic Lihue Hawaii United States 96766
    128 Saint Alphonsus Cancer Care Center-Boise Boise Idaho United States 83706
    129 Saint Luke's Cancer Institute - Boise Boise Idaho United States 83712
    130 Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho United States 83605
    131 Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho United States 83814
    132 Walter Knox Memorial Hospital Emmett Idaho United States 83617
    133 Saint Luke's Cancer Institute - Fruitland Fruitland Idaho United States 83619
    134 Idaho Urologic Institute-Meridian Meridian Idaho United States 83642
    135 Saint Luke's Cancer Institute - Meridian Meridian Idaho United States 83642
    136 Saint Alphonsus Medical Center-Nampa Nampa Idaho United States 83686
    137 Saint Luke's Cancer Institute - Nampa Nampa Idaho United States 83686
    138 Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho United States 83854
    139 Kootenai Cancer Clinic Sandpoint Idaho United States 83864
    140 Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho United States 83301
    141 Saint Anthony's Health Alton Illinois United States 62002
    142 Illinois CancerCare-Bloomington Bloomington Illinois United States 61704
    143 Loyola Center for Health at Burr Ridge Burr Ridge Illinois United States 60527
    144 Illinois CancerCare-Canton Canton Illinois United States 61520
    145 Memorial Hospital of Carbondale Carbondale Illinois United States 62902
    146 SIH Cancer Institute Carterville Illinois United States 62918
    147 Illinois CancerCare-Carthage Carthage Illinois United States 62321
    148 Centralia Oncology Clinic Centralia Illinois United States 62801
    149 University of Illinois Chicago Illinois United States 60612
    150 Cancer Care Specialists of Illinois - Decatur Decatur Illinois United States 62526
    151 Decatur Memorial Hospital Decatur Illinois United States 62526
    152 Illinois CancerCare-Dixon Dixon Illinois United States 61021
    153 Crossroads Cancer Center Effingham Illinois United States 62401
    154 Illinois CancerCare-Eureka Eureka Illinois United States 61530
    155 Illinois CancerCare-Galesburg Galesburg Illinois United States 61401
    156 Western Illinois Cancer Treatment Center Galesburg Illinois United States 61401
    157 Loyola Medicine Homer Glen Homer Glen Illinois United States 60491
    158 Illinois CancerCare-Kewanee Clinic Kewanee Illinois United States 61443
    159 Illinois CancerCare-Macomb Macomb Illinois United States 61455
    160 Loyola University Medical Center Maywood Illinois United States 60153
    161 Marjorie Weinberg Cancer Center at Loyola-Gottlieb Melrose Park Illinois United States 60160
    162 Good Samaritan Regional Health Center Mount Vernon Illinois United States 62864
    163 Cancer Care Center of O'Fallon O'Fallon Illinois United States 62269
    164 Illinois CancerCare-Ottawa Clinic Ottawa Illinois United States 61350
    165 Illinois CancerCare-Pekin Pekin Illinois United States 61554
    166 Illinois CancerCare-Peoria Peoria Illinois United States 61615
    167 Methodist Medical Center of Illinois Peoria Illinois United States 61636
    168 Illinois CancerCare-Peru Peru Illinois United States 61354
    169 Valley Radiation Oncology Peru Illinois United States 61354
    170 Illinois CancerCare-Princeton Princeton Illinois United States 61356
    171 Southern Illinois University School of Medicine Springfield Illinois United States 62702
    172 Springfield Clinic Springfield Illinois United States 62702
    173 Memorial Medical Center Springfield Illinois United States 62781
    174 Southwest Illinois Health Services LLP Swansea Illinois United States 62226
    175 Illinois CancerCare - Washington Washington Illinois United States 61571
    176 Indiana University/Melvin and Bren Simon Cancer Center Indianapolis Indiana United States 46202
    177 Community Cancer Center East Indianapolis Indiana United States 46219
    178 Community Cancer Center South Indianapolis Indiana United States 46227
    179 Community Cancer Center North Indianapolis Indiana United States 46256
    180 Springmill Medical Center Indianapolis Indiana United States 46290
    181 Community Howard Regional Health Kokomo Indiana United States 46904
    182 Reid Health Richmond Indiana United States 47374
    183 Mary Greeley Medical Center Ames Iowa United States 50010
    184 McFarland Clinic PC - Ames Ames Iowa United States 50010
    185 University of Iowa Healthcare Cancer Services Quad Cities Bettendorf Iowa United States 52722
    186 McFarland Clinic PC-Boone Boone Iowa United States 50036
    187 Saint Anthony Regional Hospital Carroll Iowa United States 51401
    188 Medical Oncology and Hematology Associates-West Des Moines Clive Iowa United States 50325
    189 Mercy Cancer Center-West Lakes Clive Iowa United States 50325
    190 Alegent Health Mercy Hospital Council Bluffs Iowa United States 51503
    191 Greater Regional Medical Center Creston Iowa United States 50801
    192 Iowa Methodist Medical Center Des Moines Iowa United States 50309
    193 Medical Oncology and Hematology Associates-Des Moines Des Moines Iowa United States 50309
    194 Broadlawns Medical Center Des Moines Iowa United States 50314
    195 Medical Oncology and Hematology Associates-Laurel Des Moines Iowa United States 50314
    196 Mercy Medical Center - Des Moines Des Moines Iowa United States 50314
    197 Iowa Lutheran Hospital Des Moines Iowa United States 50316
    198 McFarland Clinic PC-Trinity Cancer Center Fort Dodge Iowa United States 50501
    199 Trinity Regional Medical Center Fort Dodge Iowa United States 50501
    200 University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa United States 52242
    201 McFarland Clinic PC-Jefferson Jefferson Iowa United States 50129
    202 McFarland Clinic PC-Marshalltown Marshalltown Iowa United States 50158
    203 Methodist West Hospital West Des Moines Iowa United States 50266-7700
    204 Mercy Medical Center-West Lakes West Des Moines Iowa United States 50266
    205 Central Care Cancer Center - Garden City Garden City Kansas United States 67846
    206 Central Care Cancer Center - Great Bend Great Bend Kansas United States 67530
    207 University of Kansas Cancer Center-West Kansas City Kansas United States 66112
    208 University of Kansas Cancer Center Kansas City Kansas United States 66160
    209 University of Kansas Cancer Center-Overland Park Overland Park Kansas United States 66210
    210 University of Kansas Hospital-Westwood Cancer Center Westwood Kansas United States 66205
    211 Flaget Memorial Hospital Bardstown Kentucky United States 40004
    212 Commonwealth Cancer Center-Corbin Corbin Kentucky United States 40701
    213 Saint Joseph Radiation Oncology Resource Center Lexington Kentucky United States 40504
    214 Saint Joseph Hospital East Lexington Kentucky United States 40509
    215 University of Kentucky/Markey Cancer Center Lexington Kentucky United States 40536
    216 Saint Joseph London London Kentucky United States 40741
    217 Jewish Hospital Louisville Kentucky United States 40202
    218 The James Graham Brown Cancer Center at University of Louisville Louisville Kentucky United States 40202
    219 Saints Mary and Elizabeth Hospital Louisville Kentucky United States 40215
    220 Jewish Hospital Medical Center Northeast Louisville Kentucky United States 40245
    221 Jewish Hospital Medical Center South Shepherdsville Kentucky United States 40165
    222 Hematology/Oncology Clinic PLLC Baton Rouge Louisiana United States 70809
    223 Ochsner LSU Health Monroe Medical Center Monroe Louisiana United States 71202
    224 Louisiana State University Health Science Center New Orleans Louisiana United States 70112
    225 Tulane University Health Sciences Center New Orleans Louisiana United States 70112
    226 LSU Health Sciences Center at Shreveport Shreveport Louisiana United States 71103
    227 Eastern Maine Medical Center Bangor Maine United States 04401
    228 Lafayette Family Cancer Center-EMMC Brewer Maine United States 04412
    229 Walter Reed National Military Medical Center Bethesda Maryland United States 20889-5600
    230 Boston Medical Center Boston Massachusetts United States 02118
    231 Lahey Hospital and Medical Center Burlington Massachusetts United States 01805
    232 Lahey Medical Center-Peabody Peabody Massachusetts United States 01960
    233 UMass Memorial Medical Center - University Campus Worcester Massachusetts United States 01655
    234 University of Michigan Comprehensive Cancer Center Ann Arbor Michigan United States 48109
    235 Bronson Battle Creek Battle Creek Michigan United States 49017
    236 McLaren Cancer Institute-Bay City Bay City Michigan United States 48706
    237 Henry Ford Cancer Institute-Downriver Brownstown Michigan United States 48183
    238 McLaren Cancer Institute-Clarkston Clarkston Michigan United States 48346
    239 Henry Ford Macomb Hospital-Clinton Township Clinton Township Michigan United States 48038
    240 Henry Ford Medical Center-Fairlane Dearborn Michigan United States 48126
    241 Wayne State University/Karmanos Cancer Institute Detroit Michigan United States 48201
    242 Henry Ford Hospital Detroit Michigan United States 48202
    243 Weisberg Cancer Treatment Center Farmington Hills Michigan United States 48334
    244 McLaren Cancer Institute-Flint Flint Michigan United States 48532
    245 Singh and Arora Hematology Oncology PC Flint Michigan United States 48532
    246 Helen DeVos Children's Hospital at Spectrum Health Grand Rapids Michigan United States 49503
    247 Mercy Health Saint Mary's Grand Rapids Michigan United States 49503
    248 Spectrum Health at Butterworth Campus Grand Rapids Michigan United States 49503
    249 Allegiance Health Jackson Michigan United States 49201
    250 Bronson Methodist Hospital Kalamazoo Michigan United States 49007
    251 West Michigan Cancer Center Kalamazoo Michigan United States 49007
    252 Ascension Borgess Cancer Center Kalamazoo Michigan United States 49009
    253 Borgess Medical Center Kalamazoo Michigan United States 49048
    254 McLaren-Greater Lansing Lansing Michigan United States 48910
    255 Mid-Michigan Physicians-Lansing Lansing Michigan United States 48912
    256 McLaren Cancer Institute-Lapeer Region Lapeer Michigan United States 48446
    257 McLaren Cancer Institute-Central Michigan Mount Pleasant Michigan United States 48858
    258 Mercy Health Mercy Campus Muskegon Michigan United States 49444
    259 Lakeland Hospital Niles Niles Michigan United States 49120
    260 Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan United States 49444
    261 Ascension Providence Hospitals - Novi Novi Michigan United States 48374
    262 Henry Ford Medical Center-Columbus Novi Michigan United States 48377
    263 McLaren Cancer Institute-Northern Michigan Petoskey Michigan United States 49770
    264 McLaren-Port Huron Port Huron Michigan United States 48060
    265 Spectrum Health Reed City Hospital Reed City Michigan United States 49677
    266 Lakeland Medical Center Saint Joseph Saint Joseph Michigan United States 49085
    267 Marie Yeager Cancer Center Saint Joseph Michigan United States 49085
    268 Henry Ford Macomb Health Center - Shelby Township Shelby Michigan United States 48315
    269 Ascension Providence Hospitals - Southfield Southfield Michigan United States 48075
    270 Munson Medical Center Traverse City Michigan United States 49684
    271 Henry Ford West Bloomfield Hospital West Bloomfield Michigan United States 48322
    272 Metro Health Hospital Wyoming Michigan United States 49519
    273 Riverwood Healthcare Center Aitkin Minnesota United States 56431
    274 Sanford Joe Lueken Cancer Center Bemidji Minnesota United States 56601
    275 Essentia Health Saint Joseph's Medical Center Brainerd Minnesota United States 56401
    276 Fairview Ridges Hospital Burnsville Minnesota United States 55337
    277 Minnesota Oncology - Burnsville Burnsville Minnesota United States 55337
    278 Cambridge Medical Center Cambridge Minnesota United States 55008
    279 Mercy Hospital Coon Rapids Minnesota United States 55433
    280 Essentia Health - Deer River Clinic Deer River Minnesota United States 56636
    281 Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes Minnesota United States 56501
    282 Essentia Health Cancer Center Duluth Minnesota United States 55805
    283 Essentia Health Saint Mary's Medical Center Duluth Minnesota United States 55805
    284 Miller-Dwan Hospital Duluth Minnesota United States 55805
    285 Fairview Southdale Hospital Edina Minnesota United States 55435
    286 Lake Region Healthcare Corporation-Cancer Care Fergus Falls Minnesota United States 56537
    287 Essentia Health - Fosston Fosston Minnesota United States 56542
    288 Unity Hospital Fridley Minnesota United States 55432
    289 Essentia Health Hibbing Clinic Hibbing Minnesota United States 55746
    290 Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota United States 55369
    291 Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota United States 55109
    292 Saint John's Hospital - Healtheast Maplewood Minnesota United States 55109
    293 Abbott-Northwestern Hospital Minneapolis Minnesota United States 55407
    294 Hennepin County Medical Center Minneapolis Minnesota United States 55415
    295 Health Partners Inc Minneapolis Minnesota United States 55454
    296 University of Minnesota/Masonic Cancer Center Minneapolis Minnesota United States 55455
    297 Monticello Cancer Center Monticello Minnesota United States 55362
    298 New Ulm Medical Center New Ulm Minnesota United States 56073
    299 Essentia Health - Park Rapids Park Rapids Minnesota United States 56470
    300 Fairview Northland Medical Center Princeton Minnesota United States 55371
    301 North Memorial Medical Health Center Robbinsdale Minnesota United States 55422
    302 Mayo Clinic in Rochester Rochester Minnesota United States 55905
    303 Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota United States 56303
    304 Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota United States 55416
    305 Regions Hospital Saint Paul Minnesota United States 55101
    306 United Hospital Saint Paul Minnesota United States 55102
    307 Essentia Health Sandstone Sandstone Minnesota United States 55072
    308 Saint Francis Regional Medical Center Shakopee Minnesota United States 55379
    309 Lakeview Hospital Stillwater Minnesota United States 55082
    310 Sanford Thief River Falls Medical Center Thief River Falls Minnesota United States 56701
    311 Essentia Health Virginia Clinic Virginia Minnesota United States 55792
    312 Ridgeview Medical Center Waconia Minnesota United States 55387
    313 Rice Memorial Hospital Willmar Minnesota United States 56201
    314 Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota United States 55125
    315 Fairview Lakes Medical Center Wyoming Minnesota United States 55092
    316 Gulfport Memorial Hospital Gulfport Mississippi United States 39502
    317 Saint Louis Cancer and Breast Institute-Ballwin Ballwin Missouri United States 63011
    318 Central Care Cancer Center - Bolivar Bolivar Missouri United States 65613
    319 Parkland Health Center-Bonne Terre Bonne Terre Missouri United States 63628
    320 Cox Cancer Center Branson Branson Missouri United States 65616
    321 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
    322 Southeast Cancer Center Cape Girardeau Missouri United States 63703
    323 Siteman Cancer Center at West County Hospital Creve Coeur Missouri United States 63141
    324 Parkland Health Center - Farmington Farmington Missouri United States 63640
    325 Capital Region Southwest Campus Jefferson City Missouri United States 65109
    326 Freeman Health System Joplin Missouri United States 64804
    327 Mercy Hospital Joplin Joplin Missouri United States 64804
    328 University of Kansas Cancer Center - North Kansas City Missouri United States 64154
    329 University of Kansas Cancer Center - Lee's Summit Lee's Summit Missouri United States 64064
    330 University of Kansas Cancer Center at North Kansas City Hospital North Kansas City Missouri United States 64116
    331 Delbert Day Cancer Institute at PCRMC Rolla Missouri United States 65401
    332 Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri United States 65401
    333 Heartland Regional Medical Center Saint Joseph Missouri United States 64506
    334 Saint Louis Cancer and Breast Institute-South City Saint Louis Missouri United States 63109
    335 Washington University School of Medicine Saint Louis Missouri United States 63110
    336 Mercy Hospital South Saint Louis Missouri United States 63128
    337 Siteman Cancer Center-South County Saint Louis Missouri United States 63129
    338 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
    339 Siteman Cancer Center at Christian Hospital Saint Louis Missouri United States 63136
    340 Mercy Hospital Saint Louis Saint Louis Missouri United States 63141
    341 Siteman Cancer Center at Saint Peters Hospital Saint Peters Missouri United States 63376
    342 Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri United States 63670
    343 Mercy Hospital Springfield Springfield Missouri United States 65804
    344 CoxHealth South Hospital Springfield Missouri United States 65807
    345 Missouri Baptist Sullivan Hospital Sullivan Missouri United States 63080
    346 Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri United States 63127
    347 Mercy Hospital Washington Washington Missouri United States 63090
    348 Community Hospital of Anaconda Anaconda Montana United States 59711
    349 Billings Clinic Cancer Center Billings Montana United States 59101
    350 Bozeman Deaconess Hospital Bozeman Montana United States 59715
    351 Benefis Healthcare- Sletten Cancer Institute Great Falls Montana United States 59405
    352 Great Falls Clinic Great Falls Montana United States 59405
    353 Kalispell Regional Medical Center Kalispell Montana United States 59901
    354 Saint Patrick Hospital - Community Hospital Missoula Montana United States 59802
    355 Community Medical Hospital Missoula Montana United States 59804
    356 CHI Health Saint Francis Grand Island Nebraska United States 68803
    357 CHI Health Good Samaritan Kearney Nebraska United States 68847
    358 Saint Elizabeth Regional Medical Center Lincoln Nebraska United States 68510
    359 Nebraska Methodist Hospital Omaha Nebraska United States 68114
    360 Alegent Health Immanuel Medical Center Omaha Nebraska United States 68122
    361 Alegent Health Bergan Mercy Medical Center Omaha Nebraska United States 68124
    362 Alegent Health Lakeside Hospital Omaha Nebraska United States 68130
    363 Creighton University Medical Center Omaha Nebraska United States 68131
    364 Midlands Community Hospital Papillion Nebraska United States 68046
    365 Cooper Hospital University Medical Center Camden New Jersey United States 08103
    366 The Valley Hospital-Luckow Pavilion Paramus New Jersey United States 07652
    367 Neurosurgeons of New Jersey-Ridgewood Ridgewood New Jersey United States 07450
    368 Valley Hospital Ridgewood New Jersey United States 07450
    369 Valley Health System-Hematology/Oncology Westwood New Jersey United States 07675
    370 University of New Mexico Cancer Center Albuquerque New Mexico United States 87102
    371 New Mexico Oncology Hematology Consultants Albuquerque New Mexico United States 87109
    372 NYP/Weill Cornell Medical Center New York New York United States 10065
    373 Rochester General Hospital Rochester New York United States 14621
    374 University of Rochester Rochester New York United States 14642
    375 Stony Brook University Medical Center Stony Brook New York United States 11794
    376 AdventHealth Infusion Center Asheville Asheville North Carolina United States 28803
    377 UNC Lineberger Comprehensive Cancer Center Chapel Hill North Carolina United States 27599
    378 Carolinas Medical Center/Levine Cancer Institute Charlotte North Carolina United States 28203
    379 Southeastern Medical Oncology Center-Clinton Clinton North Carolina United States 28328
    380 AdventHealth Infusion Center Haywood Clyde North Carolina United States 28721
    381 Atrium Health Cabarrus/LCI-Concord Concord North Carolina United States 28025
    382 Duke University Medical Center Durham North Carolina United States 27710
    383 Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina United States 27534
    384 AdventHealth Hendersonville Hendersonville North Carolina United States 28792
    385 Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina United States 28546
    386 Vidant Oncology-Kenansville Kenansville North Carolina United States 28349
    387 Vidant Oncology-Kinston Kinston North Carolina United States 28501
    388 FirstHealth of the Carolinas-Moore Regional Hospital Pinehurst North Carolina United States 28374
    389 Vidant Oncology-Richlands Richlands North Carolina United States 28574
    390 AdventHealth Infusion Center Weaverville Weaverville North Carolina United States 28787
    391 Wake Forest University Health Sciences Winston-Salem North Carolina United States 27157
    392 Sanford Bismarck Medical Center Bismarck North Dakota United States 58501
    393 Essentia Health Cancer Center-South University Clinic Fargo North Dakota United States 58103
    394 Sanford South University Medical Center Fargo North Dakota United States 58103
    395 Southpointe-Sanford Medical Center Fargo Fargo North Dakota United States 58103
    396 Sanford Medical Center Fargo Fargo North Dakota United States 58104
    397 Sanford Broadway Medical Center Fargo North Dakota United States 58122
    398 Sanford Roger Maris Cancer Center Fargo North Dakota United States 58122
    399 Essentia Health - Jamestown Clinic Jamestown North Dakota United States 58401
    400 Indu and Raj Soin Medical Center Beavercreek Ohio United States 45431
    401 Strecker Cancer Center-Belpre Belpre Ohio United States 45714
    402 Saint Elizabeth Boardman Hospital Boardman Ohio United States 44512
    403 Dayton Physicians LLC-Miami Valley South Centerville Ohio United States 45459
    404 Miami Valley Hospital South Centerville Ohio United States 45459
    405 Geauga Hospital Chardon Ohio United States 44024
    406 Adena Regional Medical Center Chillicothe Ohio United States 45601
    407 Good Samaritan Hospital - Cincinnati Cincinnati Ohio United States 45220
    408 Oncology Hematology Care Inc-Kenwood Cincinnati Ohio United States 45236
    409 Bethesda North Hospital Cincinnati Ohio United States 45242
    410 TriHealth Cancer Institute-Westside Cincinnati Ohio United States 45247
    411 TriHealth Cancer Institute-Anderson Cincinnati Ohio United States 45255
    412 Case Western Reserve University Cleveland Ohio United States 44106
    413 Cleveland Clinic Cancer Center/Fairview Hospital Cleveland Ohio United States 44111
    414 Cleveland Clinic Foundation Cleveland Ohio United States 44195
    415 Ohio State University Comprehensive Cancer Center Columbus Ohio United States 43210
    416 Mount Carmel East Hospital Columbus Ohio United States 43213
    417 Columbus Oncology and Hematology Associates Inc Columbus Ohio United States 43214
    418 Riverside Methodist Hospital Columbus Ohio United States 43214
    419 Grant Medical Center Columbus Ohio United States 43215
    420 The Mark H Zangmeister Center Columbus Ohio United States 43219
    421 Mount Carmel Health Center West Columbus Ohio United States 43222
    422 Doctors Hospital Columbus Ohio United States 43228
    423 Miami Valley Hospital Dayton Ohio United States 45409
    424 Dayton Physician LLC-Miami Valley Hospital North Dayton Ohio United States 45415
    425 Miami Valley Hospital North Dayton Ohio United States 45415
    426 Dayton Veterans Affairs Medical Center Dayton Ohio United States 45428
    427 Delaware Health Center-Grady Cancer Center Delaware Ohio United States 43015
    428 Grady Memorial Hospital Delaware Ohio United States 43015
    429 Dublin Methodist Hospital Dublin Ohio United States 43016
    430 Armes Family Cancer Center Findlay Ohio United States 45840
    431 Blanchard Valley Hospital Findlay Ohio United States 45840
    432 Orion Cancer Care Findlay Ohio United States 45840
    433 Atrium Medical Center-Middletown Regional Hospital Franklin Ohio United States 45005-1066
    434 Dayton Physicians LLC-Atrium Franklin Ohio United States 45005
    435 Central Ohio Breast and Endocrine Surgery Gahanna Ohio United States 43230
    436 Dayton Physicians LLC-Wayne Greenville Ohio United States 45331
    437 Wayne Hospital Greenville Ohio United States 45331
    438 Mount Carmel Grove City Hospital Grove City Ohio United States 43123
    439 Greater Dayton Cancer Center Kettering Ohio United States 45409
    440 First Dayton Cancer Care Kettering Ohio United States 45420
    441 Kettering Medical Center Kettering Ohio United States 45429
    442 Fairfield Medical Center Lancaster Ohio United States 43130
    443 Saint Rita's Medical Center Lima Ohio United States 45801
    444 OhioHealth Mansfield Hospital Mansfield Ohio United States 44903
    445 Cleveland Clinic Cancer Center Mansfield Mansfield Ohio United States 44906
    446 Marietta Memorial Hospital Marietta Ohio United States 45750
    447 OhioHealth Marion General Hospital Marion Ohio United States 43302
    448 Hillcrest Hospital Cancer Center Mayfield Heights Ohio United States 44124
    449 UH Seidman Cancer Center at Landerbrook Health Center Mayfield Heights Ohio United States 44124
    450 Knox Community Hospital Mount Vernon Ohio United States 43050
    451 Licking Memorial Hospital Newark Ohio United States 43055
    452 Newark Radiation Oncology Newark Ohio United States 43055
    453 Mercy Health Perrysburg Cancer Center Perrysburg Ohio United States 43551
    454 Southern Ohio Medical Center Portsmouth Ohio United States 45662
    455 North Coast Cancer Care Sandusky Ohio United States 44870
    456 UH Seidman Cancer Center at Firelands Regional Medical Center Sandusky Ohio United States 44870
    457 Springfield Regional Cancer Center Springfield Ohio United States 45504
    458 Springfield Regional Medical Center Springfield Ohio United States 45505
    459 Cleveland Clinic Cancer Center Strongsville Strongsville Ohio United States 44136
    460 Saint Vincent Mercy Medical Center Toledo Ohio United States 43608
    461 Mercy Health - Saint Anne Hospital Toledo Ohio United States 43623
    462 Dayton Physicians LLC-Upper Valley Troy Ohio United States 45373
    463 Upper Valley Medical Center Troy Ohio United States 45373
    464 South Pointe Hospital Warrensville Heights Ohio United States 44122
    465 Saint Joseph Warren Hospital Warren Ohio United States 44484
    466 Saint Ann's Hospital Westerville Ohio United States 43081
    467 UH Seidman Cancer Center at Saint John Medical Center Westlake Ohio United States 44145
    468 Cleveland Clinic Wooster Family Health and Surgery Center Wooster Ohio United States 44691
    469 Wright-Patterson Medical Center Wright-Patterson Air Force Base Ohio United States 45433
    470 Saint Elizabeth Youngstown Hospital Youngstown Ohio United States 44501
    471 Genesis Healthcare System Cancer Care Center Zanesville Ohio United States 43701
    472 Cancer Centers of Southwest Oklahoma Research Lawton Oklahoma United States 73505
    473 University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States 73104
    474 Mercy Hospital Oklahoma City Oklahoma City Oklahoma United States 73120
    475 Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa Oklahoma United States 74146
    476 Saint Alphonsus Medical Center-Baker City Baker City Oregon United States 97814
    477 Saint Charles Health System Bend Oregon United States 97701
    478 Clackamas Radiation Oncology Center Clackamas Oregon United States 97015
    479 Providence Cancer Institute Clackamas Clinic Clackamas Oregon United States 97015
    480 Bay Area Hospital Coos Bay Oregon United States 97420
    481 Three Rivers Community Hospital Grants Pass Oregon United States 97527
    482 Rogue Valley Medical Center Medford Oregon United States 97504
    483 Providence Newberg Medical Center Newberg Oregon United States 97132
    484 Saint Alphonsus Medical Center-Ontario Ontario Oregon United States 97914
    485 Legacy Good Samaritan Hospital and Medical Center Portland Oregon United States 97210
    486 Providence Portland Medical Center Portland Oregon United States 97213
    487 Providence Saint Vincent Medical Center Portland Oregon United States 97225
    488 Kaiser Permanente Northwest Portland Oregon United States 97227
    489 Oregon Health and Science University Portland Oregon United States 97239
    490 Portland VA Medical Center Portland Oregon United States 97239
    491 Saint Charles Health System-Redmond Redmond Oregon United States 97756
    492 Christiana Care Health System-Concord Health Center Chadds Ford Pennsylvania United States 19317
    493 Geisinger Medical Center Danville Pennsylvania United States 17822
    494 Penn State Milton S Hershey Medical Center Hershey Pennsylvania United States 17033-0850
    495 University of Pennsylvania/Abramson Cancer Center Philadelphia Pennsylvania United States 19104
    496 Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania United States 18711
    497 Ralph H Johnson VA Medical Center Charleston South Carolina United States 29401
    498 Medical University of South Carolina Charleston South Carolina United States 29425
    499 McLeod Regional Medical Center Florence South Carolina United States 29506
    500 Saint Francis Hospital Greenville South Carolina United States 29601
    501 Saint Francis Cancer Center Greenville South Carolina United States 29607
    502 Avera Cancer Institute Sioux Falls South Dakota United States 57105
    503 Saint Joseph Regional Cancer Center Bryan Texas United States 77802
    504 M D Anderson Cancer Center Houston Texas United States 77030
    505 Huntsman Cancer Institute/University of Utah Salt Lake City Utah United States 84112
    506 Virginia Commonwealth University/Massey Cancer Center Richmond Virginia United States 23298
    507 Providence Regional Cancer System-Aberdeen Aberdeen Washington United States 98520
    508 PeaceHealth Saint Joseph Medical Center Bellingham Washington United States 98225
    509 Harrison HealthPartners Hematology and Oncology-Bremerton Bremerton Washington United States 98310
    510 Harrison Medical Center Bremerton Washington United States 98310
    511 Highline Medical Center-Main Campus Burien Washington United States 98166
    512 Providence Regional Cancer System-Centralia Centralia Washington United States 98531
    513 Swedish Cancer Institute-Edmonds Edmonds Washington United States 98026
    514 Saint Elizabeth Hospital Enumclaw Washington United States 98022
    515 Providence Regional Cancer Partnership Everett Washington United States 98201
    516 Saint Francis Hospital Federal Way Washington United States 98003
    517 Swedish Cancer Institute-Issaquah Issaquah Washington United States 98029
    518 Kadlec Clinic Hematology and Oncology Kennewick Washington United States 99336
    519 Providence Regional Cancer System-Lacey Lacey Washington United States 98503
    520 Saint Clare Hospital Lakewood Washington United States 98499
    521 PeaceHealth Saint John Medical Center Longview Washington United States 98632
    522 Harrison HealthPartners Hematology and Oncology-Poulsbo Poulsbo Washington United States 98370
    523 Pacific Gynecology Specialists Seattle Washington United States 98104
    524 Swedish Medical Center-Ballard Campus Seattle Washington United States 98107
    525 Swedish Medical Center-First Hill Seattle Washington United States 98122-4307
    526 Swedish Medical Center-Cherry Hill Seattle Washington United States 98122-5711
    527 PeaceHealth United General Medical Center Sedro-Woolley Washington United States 98284
    528 Providence Regional Cancer System-Shelton Shelton Washington United States 98584
    529 Franciscan Research Center-Northwest Medical Plaza Tacoma Washington United States 98405
    530 Northwest Medical Specialties PLLC Tacoma Washington United States 98405
    531 PeaceHealth Southwest Medical Center Vancouver Washington United States 98664
    532 Providence Saint Mary Regional Cancer Center Walla Walla Washington United States 99362
    533 Providence Regional Cancer System-Yelm Yelm Washington United States 98597
    534 United Hospital Center Bridgeport West Virginia United States 26330
    535 WVUH-Berkely Medical Center Martinsburg West Virginia United States 25401
    536 West Virginia University Healthcare Morgantown West Virginia United States 26506
    537 Camden Clark Medical Center Parkersburg West Virginia United States 26101
    538 ThedaCare Regional Cancer Center Appleton Wisconsin United States 54911
    539 Duluth Clinic Ashland Ashland Wisconsin United States 54806
    540 Northwest Wisconsin Cancer Center Ashland Wisconsin United States 54806
    541 Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin United States 53105
    542 Aurora Saint Luke's South Shore Cudahy Wisconsin United States 53110
    543 Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin United States 54701
    544 Mayo Clinic Health System-Eau Claire Clinic Eau Claire Wisconsin United States 54701
    545 Mayo Clinic Health System Eau Claire Hospital-Luther Campus Eau Claire Wisconsin United States 54703
    546 Aurora Health Care Germantown Health Center Germantown Wisconsin United States 53022
    547 Aurora Cancer Care-Grafton Grafton Wisconsin United States 53024
    548 Bellin Memorial Hospital Green Bay Wisconsin United States 54301
    549 Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin United States 54301
    550 Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay Wisconsin United States 54303
    551 Aurora BayCare Medical Center Green Bay Wisconsin United States 54311
    552 Aurora Cancer Care-Kenosha South Kenosha Wisconsin United States 53142
    553 Gundersen Lutheran Medical Center La Crosse Wisconsin United States 54601
    554 University of Wisconsin Hospital and Clinics Madison Wisconsin United States 53792
    555 Aurora Bay Area Medical Group-Marinette Marinette Wisconsin United States 54143
    556 Marshfield Medical Center-Marshfield Marshfield Wisconsin United States 54449
    557 Aurora Cancer Care-Milwaukee Milwaukee Wisconsin United States 53209
    558 Aurora Saint Luke's Medical Center Milwaukee Wisconsin United States 53215
    559 Medical College of Wisconsin Milwaukee Wisconsin United States 53226
    560 Aurora Sinai Medical Center Milwaukee Wisconsin United States 53233
    561 Marshfield Clinic-Minocqua Center Minocqua Wisconsin United States 54548
    562 ProHealth D N Greenwald Center Mukwonago Wisconsin United States 53149
    563 Froedtert and MCW Moorland Reserve Health Center New Berlin Wisconsin United States 53151
    564 Cancer Center of Western Wisconsin New Richmond Wisconsin United States 54017
    565 ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin United States 53066
    566 Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls Wisconsin United States 54154
    567 Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin United States 54904
    568 Aurora Cancer Care-Racine Racine Wisconsin United States 53406
    569 Marshfield Medical Center-Rice Lake Rice Lake Wisconsin United States 54868
    570 Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin United States 53081
    571 Marshfield Clinic Stevens Point Center Stevens Point Wisconsin United States 54482
    572 Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay Wisconsin United States 54235-1495
    573 Aurora Medical Center in Summit Summit Wisconsin United States 53066
    574 Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin United States 54241
    575 ProHealth Waukesha Memorial Hospital Waukesha Wisconsin United States 53188
    576 UW Cancer Center at ProHealth Care Waukesha Wisconsin United States 53188
    577 ThedaCare Cancer Care - Waupaca Waupaca Wisconsin United States 54981
    578 Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin United States 53226
    579 Aurora West Allis Medical Center West Allis Wisconsin United States 53227
    580 Marshfield Medical Center - Weston Weston Wisconsin United States 54476
    581 Billings Clinic-Cody Cody Wyoming United States 82414
    582 Welch Cancer Center Sheridan Wyoming United States 82801

    Sponsors and Collaborators

    • Southwest Oncology Group
    • National Cancer Institute (NCI)
    • Janssen, LP
    • Adaptive

    Investigators

    • Principal Investigator: Amrita Krishnan, MD, FACP, City of Hope Medical Center
    • Principal Investigator: Parameswaran Hari, MD, Medical College of Wisconsin

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Southwest Oncology Group
    ClinicalTrials.gov Identifier:
    NCT04071457
    Other Study ID Numbers:
    • S1803
    • U10CA180888
    • NCI-2018-02465
    First Posted:
    Aug 28, 2019
    Last Update Posted:
    Nov 9, 2021
    Last Verified:
    Nov 1, 2021
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Studies a U.S. FDA-regulated Drug Product:
    Yes
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Nov 9, 2021