Branched-chain Amino Acids Supplementation and Resistance Exercise-induced Muscle Damage and Inflammation

• Sponsor: University of Sao Paulo (Other)
• Overall Status: Suspended
• CT.gov ID: NCT01305018
• Collaborator: (none)
• Enrollment: 30
• Location: 1
• Arms: 3
• Duration (Months): 12
• Patients Per Site Per Month: 2.5

Study Details

Study Description

Brief Summary

This study aims to evaluate the effects of branched-chain amino acids (BCAA) supplementation on resistance exercise-induced muscle damage and inflammation.

Condition or Disease	Intervention/Treatment	Phase
Muscle Damage; Inflammation	Dietary Supplement: BCAA; Dietary Supplement: Leucine; Dietary Supplement: Placebo	N/A

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 30 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Double (Participant, Investigator)
• Primary Purpose: Treatment
• Official Title: Effects of Leucine and Branched-chain Amino Acids (BCAA) Supplementation on Resistance Exercise-induced Muscle Damage and Inflammation: a Randomized, Double-blind, and Placebo-controlled Study
• Study Start Date: Aug 1, 2011
• Anticipated Primary Completion Date: Jan 1, 2012
• Anticipated Study Completion Date: Aug 1, 2012

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Exercise and BCAA	Dietary Supplement: BCAA; 7 g of leucine + 3,5 g of isoleucine + 3,5 g of valine per day during 9 days
Experimental: Exercise and Leucine	Dietary Supplement: Leucine; 7 g of leucine + 7 g of alanine per day during 9 days
Placebo Comparator: Exercise and Placebo	Dietary Supplement: Placebo; 14 g of alanine per day during 9 days

Outcome Measures

Primary Outcome Measures

1. Muscle maximal strength [4 days]

2. Muscle edema [4 days]

3. Muscle soreness [4 days]

Secondary Outcome Measures

1. Muscle inflammation [4 days]

   Immunohistochemistry, protein expression.

2. Muscle damage [4 days]

   Serum creatine kinase

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 30 Years
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Sedentary;

• No muscle disorders;

• Must be able to swallow tablets

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of São Paulo - School of Physical Education and Sports	São Paulo		Brazil	05508-030

Sponsors and Collaborators

• University of Sao Paulo

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT01305018
• Other Study ID Numbers: 071287
• First Posted: Feb 28, 2011
• Last Update Posted: May 5, 2011
• Last Verified: Apr 1, 2011

• Keywords provided by , ,: Branched-chain amino acids; Leucine; Muscle damage; Inflammation; supplementation; resistance exercise-induced
• Additional relevant MeSH terms: Inflammation

Study Results

No Results Posted as of May 5, 2011