A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral GB2064 in Participants With Myelofibrosis

Sponsor
Galecto Biotech AB (Industry)
Overall Status
Recruiting
CT.gov ID
NCT04679870
Collaborator
OPIS s.r.l (Other)
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Study Details

Study Description

Brief Summary

This study is an open label, phase IIa trial in subjects with Myelofibrosis

Condition or Disease Intervention/Treatment Phase
Phase 2

Detailed Description

This study is designed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of orally administered GB2064 a LOXL-2 inhibitor over 9 months. Subjects will receive doses of GB2064, given twice per day to participants with primary or secondary Myelofibrosis

Study Design

Study Type:
Interventional
Anticipated Enrollment :
21 participants
Allocation:
N/A
Intervention Model:
Single Group Assignment
Intervention Model Description:
All subjects eligible for the study will receive GB2064 1000mg, twice a dayAll subjects eligible for the study will receive GB2064 1000mg, twice a day
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
An Open-label, Phase IIa Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral GB2064 (a LOXL2 Inhibitor) in Participants With Myelofibrosis (MF)
Actual Study Start Date :
Jun 9, 2021
Anticipated Primary Completion Date :
Dec 31, 2022
Anticipated Study Completion Date :
Dec 31, 2022

Arms and Interventions

Arm Intervention/Treatment
Experimental: GB2064

GB2064 will be administered orally as 4 x 250 mg tablets twice a day.

Drug: GB2064
GB2064 (formerly PAT-1251) is a high-affinity, selective, mechanism-based, small molecule inhibitor of LOXL2, administered twice a day

Outcome Measures

Primary Outcome Measures

  1. Safety and tolerability of GB2064: AE [9 Months]

    Incidence and severity of adverse events as reported by investigators

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
Participants must satisfy all of the following criteria at the Screening visit:
  1. Adult male or female participants ≥ 18 years of age at enrolment:

  2. Female participants may be of non-childbearing potential defined as permanently sterile or postmenopausal, or female participants considered to be of childbearing potential who agree to use highly effective birth control methods until 90 days after the follow-up visit. Female participants should refrain from ova donation from the date of Enrolment (Day -1) until 90 days after the follow-up visit.

  3. Male participants will agree to use contraception throughout the study and until 90-days after the Follow-up visit. Male participants must agree to refrain from sperm donation from the date of Enrolment (Day -1) until 90 days after the follow-up visit.

  4. Diagnosis of PMF or SMF with intermediate -2 or high-risk disease according to the Dynamic International Prognostic Scoring System (DIPSS)-plus or if with low risk disease then with symptomatic splenomegaly as defined by sonographic assessment as spleen length of >12 cm or by physical examination as ≥ 5 cm below left costal margin.

  5. Participants who are not currently taking a Janus kinase (JAK) inhibitor (e.g. ruxolitinib or fedratinib) and are therefore refractory, intolerant or ineligible for a JAK inhibitor according to appropriate guidelines (including local guidelines).

  6. Eastern Cooperative Oncology Group (ECOG) performance status 0-2.

  7. Required baseline laboratory status:

  8. Absolute platelet count (APC) ≥ 50 x 109/L

  9. Absolute neutrophil count (ANC) ≥ 1.5 x 109/L (1500/mm3)

  10. Serum direct bilirubin ≤ 2.0 x ULN (upper limit of normal)

  11. AST (SGOT) or ALT (SGPT) [if both measured, then this applies to both measurements] ≤ 2.5 x ULN, except for participants with MF involvement of the liver who must have levels ≤ 5 x ULN

  12. Estimated Glomerular Filtration Rate (eGFR) or creatinine clearance (CrCl) (CrCl calculated by the Cockroft and Gault method) ≥ 30 ml/min/1.73 m2.

  13. Peripheral blood blasts <10%

  14. Treatment-related toxicities from prior therapies must have resolved to Common Terminology Criteria for Adverse Events (CTCAE) Grade ≤ 1.

  15. Participants must have a documented history of transfusion records (if there have been any such transfusions) in the preceding 12 weeks to Day 1.

Exclusion Criteria:
  1. Current treatment with a JAK inhibitor (e.g. ruxolitinib or fedratinib) or a history of treatment with a JAK inhibitor within two weeks of enrolment.

  2. Positive hepatitis panel and/or positive HIV test.

  3. Any concurrent severe and/or uncontrolled medical conditions that could increase the participant's risk for toxicity while in the study or that could confound discrimination between disease- and study treatment-related toxicities. Any planned major surgery during the study period

  4. Impaired cardiac function or clinically significant cardiac diseases, including any of the following:

  5. History or presence of ventricular tachyarrhythmia.

  6. Presence of unstable atrial fibrillation (ventricular response > 100 bpm); Participants with stable atrial fibrillation are eligible, provided they do not meet any of the other cardiac exclusion criteria.

  7. Clinically significant resting bradycardia (< 50 bpm) and use of a cardiac pacemaker or implantable cardioverter defibrillator.

  8. Angina pectoris or acute myocardial infarction ≤ 90 days prior to starting study drug.

  9. Other clinically significant heart disease (e.g., symptomatic congestive heart failure; uncontrolled arrhythmia or hypertension; history of labile hypertension or poor compliance with an antihypertensive regimen).

  10. Participants who are currently receiving chronic (> 14 days) treatment with corticosteroids at a dose > 10 mg of prednisone (or its glucocorticoid equivalent) per day, or any other chronic immunosuppressive treatment that cannot be discontinued prior to starting study drug.

  11. Participants with impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of GB2064 as per physician's opinion.

  12. Participants who received radiotherapy within the last month prior to screening procedures, or patients who received splenectomy in the previous three months or are scheduled for the procedure in the next three months.

  13. Participants who had a history of malignancy in the past 3 years, except for treated early stage squamous, basal cell carcinoma or treated, localised prostate cancer.

  14. Presence of clinically meaningful active bacterial, fungal, parasitic or viral infection which requires therapy.

  15. Previous history of Progressive Multifocal Leuko-encephalopathy (PML).

  16. Pregnant or breast feeding (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive β- HCG laboratory test.

  17. Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during dosing and for 90 days after study treatment. Highly effective contraception methods must be used.

  18. Sexually active males must use a condom during intercourse while taking the drug and for 90 days after stopping study drug and should not father a child in this period. A condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid.

  19. Hypersensitivity to GB2064 and/or its excipients.

  20. Participants unable or unwilling to comply with protocol requirements.

  21. Participants related to PI/site staff.

  22. Participants who have had a hematopoietic stem cell transplantation.

  23. Participants who are eligible, have a donor and are willing to undergo a hematopoietic stem cell transplantation.

Contacts and Locations

Locations

Site City State Country Postal Code
1 MD Andersson Cancer Hospital Houston Texas United States 77030
2 Woden Dermatology Canberra Australia 2605
3 Heinrich-Heine-University Dusseldorf Düsseldorf Germany 40225
4 Universitätsklinikum Heidelberg Heidelberg Germany 69120
5 Universität Leipzig Leipzig Germany 04103
6 Praxis für Haemathologie and Onkologie am Isartor München Germany 80331
7 Klinikum rechts der Isar der Technischen Universitaet Munchen München Germany 81675
8 University of Bologna Sant Orsola Malpighi Bologna Italy 40138
9 Azienda Ospedaliero-Universitaria Careggi Firenze Italy 50134
10 ASST Grande Ospedale Metropolitano Niguarda Milano Italy 20162
11 Azienda Ospedaliero-Universitaria San Luigi Gonzaga di Orbassano Orbassano Italy 10043
12 Azienda Socio-Sanitaria Territoriale dei Sette Laghi Varese Italy 21100

Sponsors and Collaborators

  • Galecto Biotech AB
  • OPIS s.r.l

Investigators

  • Principal Investigator: Srdan Verstovsek, MD, PhD, The University of Texas MD Anderson Cancer Center, Houston, TX

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Galecto Biotech AB
ClinicalTrials.gov Identifier:
NCT04679870
Other Study ID Numbers:
  • MYLOX-1
  • 2020-003087-45
First Posted:
Dec 22, 2020
Last Update Posted:
Jan 19, 2022
Last Verified:
Jan 1, 2022
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
Yes
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Galecto Biotech AB
Additional relevant MeSH terms:

Study Results

No Results Posted as of Jan 19, 2022