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Myocardial Function Assessment in Patients With Coronary Artery Disease Using Noninvasive Myocardial Work

Sponsor
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (Other)
Overall Status
Active, not recruiting
CT.gov ID
NCT05874752
Collaborator
(none)
130
Enrollment
1
Location
20
Anticipated Duration (Months)
6.5
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Noninvasive pressure-strain loop (PSL) derived myocardial work (MW) are more sensitive than conventional echocardiographic parameters in quantitative assessment of early myocardial dysfunction. The aim of this study was to assess left ventricular (LV) myocardial function in symptomatic patients with coronary artery disease using the promising method.

Methods: Transthoracic echocardiography was performed on patients with angina or equivalent symptoms before coronary angiography. Images were stored and imported into the software for further offline analysis of PSL-based MW. MW analysis were carried out on each patient for global and regional myocardial function assessment.

Condition or Disease Intervention/Treatment Phase
  • Diagnostic Test: Transthoracic echocardiography

Study Design

Study Type:
Observational
Actual Enrollment :
130 participants
Observational Model:
Other
Time Perspective:
Retrospective
Official Title:
Myocardial Function Assessment in Patients With Coronary Artery Disease Using Noninvasive Myocardial Work
Actual Study Start Date :
Oct 1, 2021
Anticipated Primary Completion Date :
Jun 1, 2023
Anticipated Study Completion Date :
Jun 1, 2023

Arms and Interventions

Arm Intervention/Treatment
nonsignificant coronary artery stenosis group

Exclusion criteria: ≥70% proximal luminal stenosis in at least one major coronary vessel based on coronary angiography

Diagnostic Test: Transthoracic echocardiography
noninvasive myocardial work
significant coronary artery stenosis group

Defined as ≥70% proximal luminal stenosis in at least one major coronary vessel based on coronary angiography

Diagnostic Test: Transthoracic echocardiography
noninvasive myocardial work

Outcome Measures

Primary Outcome Measures

  1. myocardial function [baseline (before coronary angiography)]

    noninvasive myocardial work indices

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 80 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No

Inclusion Criteria: Patients who were hospitalized for coronary angiography with angina or equivalent symptoms.

-

Exclusion Criteria: Acute coronary syndrome, left main stem coronary disease, left ventricular ejection fraction (LVEF) below 55%, observed resting regional wall motion abnormalities (RWMAs), non-sinus rhythm, intraventricular block, previous cardiac surgery, severe valvular heart disease, hypertrophic cardiomyopathy, myocarditis, pericardial diseases, pulmonary hypertension, and poor image quality.

-

Contacts and Locations

Locations

Site City State Country Postal Code
1 Sun Yat-sen Memorial Hospital Guangzhou Guangdong China 510120

Sponsors and Collaborators

  • Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Investigators

  • Principal Investigator: Yingmei Liu, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
ClinicalTrials.gov Identifier:
NCT05874752
Other Study ID Numbers:
  • SYSKY-2022-029-01
First Posted:
May 25, 2023
Last Update Posted:
May 25, 2023
Last Verified:
Apr 1, 2023
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease

Study Results

No Results Posted as of May 25, 2023