COCARDE: Myocardial Involvement of Severe Acute Respiratory Syndrome-Cov-2 (Covid19) Infected Patients
Study Details
Study Description
Brief Summary
The effects of severe acute respiratory syndrome SARS-Cov-2 (Covid-19) on the myocardium and their role in the clinical course of infected patients are still unknown. Epidemiological studies report biological myocardial involvement in 10 to 25% of cases. The objective of this study is to cardiac phenotype using comprehensive cardiac imaging tools of patients infected with Covid 19 in order to explore the functional impact of the infection on the myocardium.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
A large population of Covid 19 infected patients of different ages and severity levels will be explored by transthoracic echocardiography with measurement of myocardial functional parameters such as ejection fraction, longitudinal strain and relaxation parameters and will be compared to an uninfected population paired for age and sex.
Patients with biological myocardial involvement will be followed to determine the evolution of their myocardial functional parameters during the course of the infection.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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COVID + patients Major patients hospitalized for respiratory criteria for SARS-Cov-2 infection confirmed by RT-PCR |
Diagnostic Test: Global Longitudinal Strain
Electrocardiogram with measure of the Global Longitudinal Strain to evaluate myocardiac dysfunction
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Outcome Measures
Primary Outcome Measures
- Left ventricular function [Day 0]
Left ventricular function evaluated by global longitudinal strain
- Left ventricular function [Day 3]
Left ventricular function evaluated by global longitudinal strain
- Left ventricular function [Day 7]
Left ventricular function evaluated by global longitudinal strain
Secondary Outcome Measures
- inflammatory biological parameters [Day 0]
Cytokine rate
Eligibility Criteria
Criteria
Inclusion Criteria:
- Major patients hospitalized for respiratory criteria for SARS-Cov-2 infection confirmed by RT-PCR
Exclusion Criteria:
- Underage patients. Patients refusing to participate in research. Patients with a history of heart disease.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | UHToulouse | Toulouse | France | 31059 |
Sponsors and Collaborators
- University Hospital, Toulouse
Investigators
- Principal Investigator: Vincent MINVILLE, PU-PH, University Hospital, Toulouse
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- RC31/20/0117
- 2020-A00852-37