Corneal Endothelial Cell Injury Induced by Mitomycin-C
Study Details
Study Description
Brief Summary
our study will investigate the effecacy of Mitomycin-C in TransEpi single step photorefractive keratectomy (PRK) and alcohol assisted PRK
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Active Comparator: TransEpi single step PRK
|
Procedure: Transepithelial PRK/MMC
transepithelial photorefractive keratectomy (PRK) and mitomycin C addition
|
Active Comparator: alcohol assisted PRK
|
Procedure: Alcohol-Assisted PRK/MMC
photorefractive keratectomy (PRK) assisted by alchol and mitomycin C addition
|
Outcome Measures
Primary Outcome Measures
- Endothelial cell Density [Base line]
will be measured by Specular microscopy
- Endothelial cell Density [at 1st month]
will be measured by Specular microscopy
- Endothelial cell Density [at 3rd month]
will be measured by Specular microscopy
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age over 18 years.
-
Primary myopia or compound myopic astigmatism.
-
Preoperative manifest refraction spherical equivalent (MRSE) within the range of -1.0 to 8 D
-
Stable refractive error for at least 12 months before the surgery.
-
Contact lens discontinuation for at least 3 weeks.
-
Estimated corneal stromal bed thickness of more than 300mm at the thinnest point
Exclusion Criteria:
-
Unwilling to participate in the study.
-
Previous ocular surgery
-
Any diagnosed ocular disease
-
History of ocular trauma
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Ehab tharwat | Damieta | New Damietta | Egypt | 34517 |
Sponsors and Collaborators
- Al-Azhar University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Mitomycin-C