Neural Changes in the Aging Auditory System

Sponsor

University of Rochester (Other)

Overall Status

Completed

CT.gov ID

NCT00264407

Collaborator

Rochester Institute of Technology (Other), National Institute on Aging (NIA) (NIH), National Institute on Deafness and Other Communication Disorders (NIDCD) (NIH)

126

Enrollment

Locations

Duration (Months)

Patients Per Site

1.3

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study was to determine the effects of hormone replacement therapy (HRT) on hearing in post-menopausal women.

Condition or Disease	Intervention/Treatment	Phase
Progesterone Estrogens Hearing Psychoacoustics Auditory Perceptual Disorders	Drug: Hormone Replacement Therapy - HRT

Detailed Description

Background: Female hormone influences on the development and aging of the auditory system are not completely understood. The present study retrospectively analyzed and compared hearing abilities among post-menopausal women taking hormone replacement therapy (HRT), treated with estrogen and progesterone (E+P); estrogen alone (E), and a third (control - NHRT) group, matched for age, who did not receive any HRT.

Methods: 126 subjects, (60-86 yr), N=32, E+P; N=31, E; N= 63, NHRT; matched for age and health status participated. All had relatively healthy medical histories, absence of significant noise exposure, middle ear problems, major surgeries or current/heavy smoking. Hearing tests included pure tone audiometry (PTA), tympanometry, distortion-product otoacoustic emissions (DPOAEs), transient otoacoustic emissions (TEOAEs) and hearing-in-noise-test (HINT). The latter is a test for speech perception in background noise: the major complaint of hearing-impaired persons.

Study Design

Study Type:

Observational

Observational Model:

Case-Control

Time Perspective:

Other

Official Title:

Age-Related Hearing Loss: Presbycusis & Its Neural Bases

Study Start Date :

Jan 1, 2001

Study Completion Date :

Feb 1, 2005

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

60 Years to 86 Years

Sexes Eligible for Study:

Female

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Healthy middle ears

Exclusion Criteria:

ototoxic medications
serious medical health problems
neurological conditions
Meniere's disease or labyrinthitis
those who failed cognitive screening tests (Mini-Mental Test)
current/heavy smokers
conductive hearing loss
history of noise damage and/or audiograms signifying noise damage
poor speech discrimination scores (80% or less)

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	International Center Hearing & Speech Research - NTID - RIT	Rochester	New York	United States	14623-5604
2	University of Rochester Medical Center	Rochester	New York	United States	14642