An Intermediate Expanded Use Trial of DFMO

Sponsor

Wake Forest University Health Sciences (Other)

Overall Status

No longer available

CT.gov ID

NCT03581240

Collaborator

K C Pharmaceuticals Inc. (Industry)

Location

Study Details

Study Description

Brief Summary

To provide DFMO in an expanded use setting to subjects with relapsed rare tumors with increased LIN28 expression or MYCN amplification or up regulation of ornithine decarboxylase.

Condition or Disease	Intervention/Treatment	Phase
Neuroblastoma Medulloblastoma Typical Teratoid Rhabdoid Tumor Embryonal Tumor With Abundant Neuropil and True Rosettes Ependymoblastoma Medulloepithelioma	Drug: eflornithine HCl

Study Design

Study Type:

Expanded Access

Official Title:

An Intermediate Expanded Use Trial of DFMO

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

0 Years to 30 Years

Sexes Eligible for Study:

All

Inclusion Criteria:

Age: 0-30 years at the time of initial diagnosis.
Diagnosis: Histologic verification at either the time of original diagnosis or a previous relapse of High Risk neuroblastoma, medulloblastoma, atypical teratoid rhabdoid tumor, embryonal tumor with abundant neuropil and true rosettes, ependymoblastoma, medulloepithelioma and other rare pediatric MYC, ODC or LIN28/Let7 driven tumors (each type will form a new subset).
Disease Status: Subjects must be in one of the following disease categories:

High risk neuroblastoma patients that have completed standard of care upfront therapy and are not eligible for NMTRC014.
Medulloblastoma patients who have completed standard of care therapies.
Relapsed/refractory neuroblastoma patients who have completed standard of care therapies.
Rare tumors with increased LIN28 expression or MYCN amplification or up regulation of ornithine decarboxylase who have completed standard of care therapies.

Subjects are not eligible to enroll on DFMO studies NMTRC002, NMTRC003, NMTRC010, or NMTRC014.
A negative serum or urine pregnancy test is required for female subjects of child bearing potential (onset of menses or ≥13 years of age).
Both male and female post-pubertal study subjects need to agree to use one of the more effective birth control methods during treatment and for six months after treatment is stopped. These methods include total abstinence (no sex), oral contraceptives ("the pill"), an intrauterine device (IUD), levonorgestrol implants (Norplant), or medroxyprogesterone acetate injections (Depo-provera shots). If one of these cannot be used, contraceptive foam with a condom is recommended.
Informed Consent: All subjects and/or legal guardians must sign informed written consent. Assent, when appropriate, will be obtained according to institutional guidelines