SUNMO: A Study Evaluating Efficacy and Safety of Mosunetuzumab in Combination With Polatuzumab Vedotin Compared to Rituximab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed or Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma
Study Details
Study Description
Brief Summary
This study will assess the efficacy and safety of mosunetuzumab in combination with polatuzumab vedotin (M+P) in participants with relapsed or refractory (R/R) diffuse-large B-cell lymphoma (DLBCL), high-grade B-cell lymphoma, transformed follicular lymphoma (trFL) and FL Grade 3B (FL3B) in comparison with a commonly used regimen in this participant population, rituximab, gemcitabine and oxaliplatin (R-GemOx).
Condition or Disease | Intervention/Treatment | Phase |
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Phase 3 |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: M+P (Arm A) Participants will receive subcutaneous (SC) mosunetuzumab plus intravenous (IV) polatuzumab vedotin (M+P). Mosunetuzumab will be administered on Days 1, 8, and 15 of Cycle 1, and thereafter on Day 1 of Cycles 2-8. Polatuzumab vedotin will be administered on Day 1 of each cycle up to Cycle 6. Cycle length = 21 days. |
Drug: Mosunetuzumab
Participants will receive SC mosunetuzumab on Days 1, 8, and 15 of Cycle 1, and on Day 1 of Cycles 2-8 (cycle length = 21 days).
Drug: Polatuzumab vedotin
Participants will receive IV polatuzumab vedotin every three weeks (Q3W) for 6 cycles (cycle length = 21 days).
Drug: Tocilizumab
Participants will receive IV tocilizumab as needed to manage cytokine release syndrome (CRS) events.
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Experimental: R-GemOx (Arm B) Participants will receive IV rituximab, IV gemcitabine, and IV oxaliplatin (R-GemOx) on Day 1 of each cycle for 8 cycles. Cycle length = 14 days. |
Drug: Rituximab
Participants will receive IV rituximab on Day 1 of each cycle for 8 cycles (cycle length = 14 days).
Drug: Gemcitabine
Participants will receive IV gemcitabine on Day 1 of each cycle for 8 cycles (cycle length = 14 days).
Drug: Oxaliplatin
Participants will receive IV oxaliplatin on Day 1 of each cycle for 8 cycles (cycle length = 14 days).
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Outcome Measures
Primary Outcome Measures
- Progression-free survival (PFS) [From randomization to the first occurrence of disease progression as determined by an independent review facility (IRF), or death due to any cause, whichever occurs first (up to 2 years)]
Secondary Outcome Measures
- Objective response rate (ORR) [Up to 2 years]
- Duration of response (DOR) [The time from the first occurrence of a documented objective response to disease progression or death from any cause, whichever occurs first, as determined by the investigator and IRF (up to 2 years)]
- Overall survival (OS) [From randomization to death from any cause (up to 2 years)]
- PFS [From randomization to the first occurrence of disease progression as determined by the investigator, or death due to any cause, whichever occurs first (up to 2 years)]
- Complete response rate (CRR) [Up to 2 years]
- Duration of complete response (DOCR) [From the first occurrence of a documented complete response (CR) to disease progression or death from any cause, whichever occurs first, as determined by IRF and the investigator (up to 2 years)]
- Time to deterioration in physical functioning and fatigue as measured by the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 [Up to 2 years]
- Time to deterioration in lymphoma symptoms as measured by the functional assessment of cancer therapy lymphoma subscale (FACT-Lym LymS) [Up to 2 years]
- Incidence of adverse events (AEs) [Up to 2 years]
- Change from baseline in peripheral neuropathy as measured by the functional assessment of cancer therapy/gynecologic oncology group - neurotoxicity (FACT/GOG-NTX) [Up to 2 years]
- Serum concentration of mosunetuzumab [Up to 2 years]
- Plasma concentration of polatuzumab vedotin [Up to 2 years]
- Change from baseline in the EuroQol 5-dimension, 5-level questionnaire (EuroQol EQ 5D-5L) index-based scores [Up to 2 years]
- Change from baseline in the EuroQol EQ 5D-5L visual analog scale (VAS) scores [Up to 2 years]
- Incidence of anti-drug antibodies (ADAs) to mosunetuzumab [Up to 2 years]
- Incidence of anti-drug antibodies (ADAs) to polatuzumab vedotin [Up to 2 years]
Eligibility Criteria
Criteria
Inclusion Criteria:
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Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1, or 2
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Life expectancy of at least 12 weeks
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CD20+ aggressive lymphoma as determined by the local hemopathology laboratory from the following diagnoses by 2016 World Health Organization classification of lymphoid neoplasms: DLBCL, not otherwise specified (NOS); high-grade B-cell lymphoma (NOS or double/triple hit); trFL R/R to standard therapies to trFL; FL3B
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Received at least one prior systemic therapy for aggressive non-Hodgkin's lymphoma (aNHL)
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Have either relapsed or have become refractory to a prior regimen must meet the following criteria: relapsed to prior regimen(s) after having a documented history of response (CR or PR) of at least 6 months in duration from completion of regimen(s); refractory to any prior regimen, defined as no response to the prior therapy, or progression within 6 months of completion of the last dose of therapy
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Participants who have received only one prior line of therapy must be ineligible for autologous stem cell transplant (ASCT)
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Measurable disease, defined as at least 1 bi-dimensionally measurable nodal lesion, defined as > 1.5 cm in its longest dimension, or at least 1 bi-dimensionally measurable extra nodal lesion, defined as > 1.0 cm in its longest dimension
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Have a pathology report for the initial histopathology diagnosis and the most recent histopathology diagnosis prior to entering the study
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Representative tumor specimen and the corresponding pathology report available for confirmation of diagnosis as well as for biomarker analysis
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Adequate hepatic, hematologic, and renal function
Exclusion Criteria:
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Pregnant or breast feeding, or intending to become pregnant during the study or within 3 months after the final dose of mosunetuzumab, 9 months after the final dose of polatuzumab vedotin, 12 months after the final dose of rituximab, 6 months after the final dose of gemcitabine, 9 months after the final dose of oxaliplatin, and 3 months after the final dose of tocilizumab, as applicable
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Inability to comply with protocol-mandated activity restrictions
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Prior treatment with mosunetuzumab or other CD-20-directed bispecific antibodies, polatuzumab vedotin, or R-GemOx or Gem-Ox
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Contraindication to any component of the study treatment
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Grade > 1 peripheral neuropathy
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Received anti-lymphoma treatments with monoclonal antibodies, radio-immunoconjugates or antibody-drug conjugates (ADCs) within 4 weeks before the first dose of study treatment
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Treatment with any chemotherapeutic agent, or treatment with any other anti-cancer agent (investigational or otherwise) within 4 weeks or 5 half-lives of the drug, whichever is shorter, prior to the first dose of study treatment
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Treatment with radiotherapy within 2 weeks prior to the first dose of study treatment
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ASCT within 100 days prior to the first study treatment administration
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Prior treatment with chimeric antigen receptor (CAR) T cell therapy within 30 days before the first study treatment administration
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Prior allogenic stem cell transplant (SCT)
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Have had a solid organ transplantation
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Known or suspected history of hemophagocytic lymphohistiocytosis (HLH)
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History of confirmed progressive multifocal leukoencephalopathy
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History of severe allergic or anaphylactic reactions to monoclonal antibody therapy (or recombination antibody-related fusion proteins)
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History of malignancy that has been treated with curative intent within >/= 2 years prior to screening, with the exception of the cancer under investigation in this study and malignancies with a negligible risk of metastasis or death (e.. 5-year overall survival rate > 90%), such as adequately treated carcinoma in situ of the cervix, non-melanoma skin carcinoma, localized prostate cancer, ductal carcinoma in situ, or Stage 1 uterine cancer
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Currently have or have had a past history of central nervous system (CNS) involvement of lymphoma
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History of CNS disease which was symptomatic or required treatment in the past 1 year, such as stroke, epilepsy, CNS vasculitis, or neurodegenerative disease
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Significant cardiovascular disease such as New York Heart Association Class III or IV cardiac disease, myocardial infarction within the last 6 months, unstable arrhythmias, or unstable angina
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Significant active pulmonary disease
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Known active bacterial, viral, fungal, mycobacterial, parasitic, or other infection (excluding fungal infections of the nail beds) at study enrollment, or any major episode of infection requiring treatment with IV antibiotics or hospitalization (relating to the completion of the course of antibiotics) within 2 weeks prior to the first study treatment administration
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Known or suspected chronic active Epstein-Barr virus (EBV) infection
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Recent major surgery within 4 weeks prior to the first study treatment administration
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Positive test results for chronic hepatitis B infection
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Acute or chronic hepatitis C virus (HCV) infection
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History of HIV infection
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Have been administered a live, attenuated vaccine within 4 weeks before the first dose of study treatment administration or anticipation that such a live, attenuated vaccine will be required during the study
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History of autoimmune disease
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Received systemic immunosuppressive medications (including, but not limited to cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-TNF agents) with the exception of corticosteroid treatment </= 10 mg/day prednisone or equivalent within 2 weeks prior to first dose of study treatment
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Received investigational therapy, whether or not intended for lymphoma treatment, within 7 days prior to initiation of study treatment
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Clinically significant history of liver disease, including viral or other hepatitis, or cirrhosis
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Any serious medical condition or abnormality in clinical laboratory tests that precludes the participant's safe participation in and in the completion of the study, or which could affect compliance with the protocol or interpretation of results
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Instituto Alexander Fleming | Buenos Aires | Argentina | 1426 | |
2 | Fundaleu; Haematology | Buenos Aires | Argentina | C1114AAN | |
3 | Hospital Aleman | Ciudad Autonoma Buenos Aires | Argentina | C1118AAT | |
4 | Soroka Medical Center; Hematology Deptartment | Beer Sheva | Israel | 8410101 | |
5 | Meir Medical Center; Heamatology Dept | Kfar Saba | Israel | 4428164 | |
6 | Ichilov Sourasky Medical Center; Heamatology | Tel Aviv | Israel | 6423906 | |
7 | Pusan National University Hospital | Busan | Korea, Republic of | 49241 | |
8 | Chungnam National University Hospital | Daejeon | Korea, Republic of | 35015 | |
9 | Seoul National University Hospital | Seoul | Korea, Republic of | 03080 | |
10 | Severance Hospital, Yonsei University Health System | Seoul | Korea, Republic of | 03722 | |
11 | Samsung Medical Center | Seoul | Korea, Republic of | 06351 | |
12 | Yeouido St. Mary's Hospital | Seoul | Korea, Republic of | 07345 | |
13 | Health Pharma Professional Research | Cdmx | Mexico CITY (federal District) | Mexico | 03100 |
14 | Hospital Universitario Dr. Jose E. Gonzalez; Haematology | Monterrey | Nuevo LEON | Mexico | 64460 |
15 | Middlemore Clinical Trials | Auckland | New Zealand | ||
16 | Siriraj Hospital; Division of Hematology, Department of Medicine | Bangkok | Thailand | 10700 | |
17 | Chiang Mai Uni Hospital; Division of Hematology,Dept of Medicine,Faculty of Medicine | Chiang Mai | Thailand | 50200 | |
18 | Anadolu Health Center; Heamathology Department | Kocaeli | Turkey | 41400 | |
19 | Dokuz Eylul Universitesi Tip Fakultesi | Lzmir | Turkey | 35340 |
Sponsors and Collaborators
- Hoffmann-La Roche
Investigators
- Study Director: Clinical Trials, Hoffmann-La Roche
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- GO43643