Treatment of Non-Hodgkin's Lymphoma With 90Y-hLL2 IgG
Study Details
Study Description
Brief Summary
The purpose of this trial is to determine the safety of a 90Y-radiolabeled, humanized (CDR-grafted) form of the LL2 monoclonal antibody in patients with Non-Hodgkin's lymphoma (NHL) at different dose levels.
Condition or Disease | Intervention/Treatment | Phase |
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Phase 1/Phase 2 |
Study Design
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
Inclusion:
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Histological or cytological diagnosis of B-cell lymphoma, and has failed at least one regimen of standard chemotherapy. (All histological grades of NHL will be eligible for this trial.)
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Measureable via CT, with at least one lesion > or = 1.5cm in one or both dimensions. (Splenic tumors in absence of other tumors will not qualify.)
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Radiological studies (ie - CT) must be performed within 4 weeks prior to study start.
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Acceptable tumor burden that will allow adequate follow-up and evaluation.
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Less that 25% bone marrow involvement, determined by bone marrow biopsy.
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Must observe the following washout periods:
At least 4 weeks beyond any major surgery. At least 4 weeks beyond any radiation therapy to the index lesion, and has recovered from radiation-induced toxicity.
At least 4 weeks beyond chemotherapy and/or immunotherapy. At least 2 weeks beyond corticosteriod(s) use and blood counts are with laboratory criteria.
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Must have Karnofsky score >70% (or equivalent, ECOG 0-2) with expected survival of at least 6 months.
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Serum creatinine < or = 1.5mg/dl or creatinine clearance > or = 50ml/min.
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Serum bilirubin < or = 2mg/dl.
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Hemoglobin > or = 10 g/dl; WBC > or = 3000/mm3; granulocyte count > or = 150/mm3; platelet count > or = 100,000/mm3 with out transfusions or cytokines for at least 30 days prior to study.
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Immunomedics ELISA assay of HahLL2 < 100ng/ml for those with prior history of monoclonal antibody infusions.
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Cognizant informed consent.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Gilead Sciences
Investigators
- Study Director: William Wegener, Gilead Sciences
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- IM-T-hLL2-06-EU