Effect of Daily Infusion Time of Immunotherapy on Overall Survival in NSCLC
Study Details
Study Description
Brief Summary
This study aims to explore the effect of different infusion times (day or night) on the efficacy of immune checkpoint inhibitors on the basis of real-world efficacy of immunotherapy for advanced squamous/non-squamous non-small cell lung cancer.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: morning group The immunotherapy infusion is after 6:00 p.m |
Procedure: Time of immunotherapy infusion
Time of immunotherapy infusion
|
Experimental: afternoon group The immunotherapy infusion is after 6:00 p.m |
Procedure: Time of immunotherapy infusion
Time of immunotherapy infusion
|
Outcome Measures
Primary Outcome Measures
- ORR [1 year]
Defined as the proportion of subjects in complete remission (CR) and partial remission (PR) to the total subjects
- OS [1 year]
Defined as the time from the start of treatment to the death of the subject due to any cause.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patients with untreated non-small cell lung cancer
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ECOG score 0-2
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Asymptomatic brain metastases
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Driver gene was negative
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At least 1 measurable lesion
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First-line patients received immunological monotherapy or immunological combined chemotherapy
Exclusion Criteria:
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Failure to follow the standard treatment plan during diagnosis and treatment;
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Lack of clinical diagnosis and treatment information or loss of follow-up;
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Can't tolerate immunotherapy or ECOG score greater than 2
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Hunan Cancer Hospital | Changsha | Hunan | China | 410013 |
Sponsors and Collaborators
- Hunan Province Tumor Hospital
Investigators
- Principal Investigator: Yongchang Zhang, MD, Hunan Cancer Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- INJECTION