AS-OCT of the Cornea in Thyroid Diseases
Study Details
Study Description
Brief Summary
use the anterior segment optical coherence tomography (AS-OCT) to evaluate the tear meniscus parameters, total corneal thickness (CT), and epithelial thickness in active and inactive thyroid eye diseases (TED) patients and compare them with age-matched controls.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
A prospective case-control clinical study. The study subjects were divided into 3 groups, group 1 of inactive thyroid patients, group 2 of active thyroid patients, and group 3 of healthy controls. The AS-OCT was used to measure lower tear meniscus parameters (tear meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus area (TMA)), total CT and epithelial thickness
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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group 1 70 eyes of 35 patients of thyroid inactive disease |
Diagnostic Test: AS-OCT
Optical Coherence Tomography (OCT) creates detailed cross-sectional images of the anterior and posterior segments using low coherence interferometry. OCT is a noninvasive, real-time method for evaluating the tear meniscus, total corneal thickness (CT), and corneal epithelial thickness
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Group 2 70 eyes of 35 patients of thyroid active disease |
Diagnostic Test: AS-OCT
Optical Coherence Tomography (OCT) creates detailed cross-sectional images of the anterior and posterior segments using low coherence interferometry. OCT is a noninvasive, real-time method for evaluating the tear meniscus, total corneal thickness (CT), and corneal epithelial thickness
|
Group 3 Healthy controls |
Diagnostic Test: AS-OCT
Optical Coherence Tomography (OCT) creates detailed cross-sectional images of the anterior and posterior segments using low coherence interferometry. OCT is a noninvasive, real-time method for evaluating the tear meniscus, total corneal thickness (CT), and corneal epithelial thickness
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Outcome Measures
Primary Outcome Measures
- Tear Meniscus Height [through study completion, an average of 6 months]
represented by a line joining the points corresponding to the upper corneo-meniscus junction to the lower eyelid-meniscus junction
- Tear Meniscus Depth (TMD): [through study completion, an average of 6 months]
represented as the distance between the center of the upper boundary of the tear meniscus and the point at the bottom boundary where the cornea meets the eyelid
- Tear Meniscus Area (TMA) [through study completion, an average of 6 months]
triangular area formed by the corneal anterior boundary, anterior boundary of the lower eyelid and anterior borderline of the tear meniscus
Eligibility Criteria
Criteria
Inclusion Criteria:
- The inclusion criteria were patients with thyroid disorders with age between 20 to 60 years with no ocular manifestations
Exclusion Criteria:
- being younger than 20 or older than 60, presence of systemic diseases as diabetes mellitus (DM) and autoimmune diseases as rheumatoid arthritis (RA) that may cause dry eye, previous ocular surgery, use of contact lenses, smokers, pregnant women, and breastfeeding women.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Minia Faculty of medicine | Minya | Egypt | ||
2 | Minia University hospital | Minya | Egypt |
Sponsors and Collaborators
- Minia University
Investigators
- Principal Investigator: mohamed Mahmoud, Minia faculty of medicine
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 165-2021