Optical Coherence Tomography of Nerve Fiber Layer and Ganglion Cell Complex After Cataract Extraction
Study Details
Study Description
Brief Summary
Optical coherence tomography (OCT) for retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) is done before and after cataract extraction in patients with or without primary open angle glaucoma (POAG)
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
The investigator's study includes two groups of patients, each consists of 25 eyes, group 1 (cataract group)includes patients who are planned for cataract extraction without any other preexisting retinal or optic nerve pathology that may affect the RNFL thickness, while group 2 (combined cataract and glaucoma group) includes patients who are diagnosed with POAG controlled on medical treatment with cataract and planned for cataract extraction only.
The OCT scans with complete ophthalmological examination are done before surgery and 6 weeks after uneventful cataract extraction (phacoemulsification with intraocular lens implantation)
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Cataract group Group 1 includes patients who are planned for cataract extraction without any other preexisting retinal or optic nerve pathology that may affect the RNFL thickness. OCT (investigation) before and after cataract extraction |
Diagnostic Test: Oct scans
Oct scans to assess thickness of RNFL and GCC before and after cataract extraction surgery in both groups
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Combined cataract and glaucoma group Group 2 includes patients who are diagnosed with POAG controlled on medical treatment and have cataract and planned for cataract extraction only OCT is done before and after cataract extraction |
Diagnostic Test: Oct scans
Oct scans to assess thickness of RNFL and GCC before and after cataract extraction surgery in both groups
|
Outcome Measures
Primary Outcome Measures
- RNFL and GCC thickness [Oct scans before and 6 weeks after surgery]
Assessment of RNFL and GCC thickness change after cataract extraction
Secondary Outcome Measures
- Final best corrected visual acuity (BCVA) [Six weeks after cataract surgery]
Assessment of the final BCVA recorded according to the Snellen chart and converted to logMAR for statistical analysis
Other Outcome Measures
- Intraocular pressure (IOP) change and central foveal thickness (CFT) change [Six weeks after cataract surgery]
Assessment of the IOP and CFT change after cataract extraction
Eligibility Criteria
Criteria
Inclusion Criteria:
• patients with cataract without any other concomitant retinal, optic nerve head pathology other than POAG are included in the study and divided onto two groups
Exclusion Criteria:
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Patients having any retinal or optic nerve pathology that might have affected nerve fiber layer thickness other than POAG eg: high myopia
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POAG patients who are planned for combined surgery
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Refractive errors greater than spherical equivalent of 6 diopters (myopia or hypermetropia)
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Dense cataract hindering OCT imaging
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History of previous ocular surgery or trauma
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Kasr Al-Ainy teaching hospital | Cairo | Egypt | 11562 |
Sponsors and Collaborators
- Kasr El Aini Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- N-68-2018