OPTI-MOM: Optimizing Medication Management for Mothers With Depression

Sponsor
Northwestern University (Other)
Overall Status
Completed
CT.gov ID
NCT02519790
Collaborator
University of Pittsburgh (Other), The University of Texas Medical Branch, Galveston (Other), Marshfield Clinic (Other)
88
Enrollment
4
Locations
58.9
Actual Duration (Months)
22
Patients Per Site
0.4
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to explore the way the antidepressant concentration (amount of medication) in the blood changes due to the physiological changes in the body (i.e., changes in metabolism, hormones and body fluid) during pregnancy and postpartum and the impact of genetic factors on the degree of these changes. Changes in antidepressant concentration are important to monitor, as decreases in antidepressant concentration may lead to less than therapeutic drug levels, which may cause an increase in mood symptoms or recurrence of depressive episodes. Increases in antidepressant concentration have the potential to lead to increased side effects. The study team is hoping to better understand the course of these changes across pregnancy and postpartum and how an individual's genetic makeup impacts these changes with the goal of developing guidelines to optimize antidepressant treatment of pregnant women.

Condition or DiseaseIntervention/TreatmentPhase

    Detailed Description

    The overarching goal of this The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) funded U54 Obstetric-Fetal Pharmacology Research Center study is to develop evidence to construct guidelines for the optimal use of selective serotonin reuptake inhibitor (SSRI) antidepressants in pregnant women. The progressive changes in plasma SSRI and metabolite concentrations across pregnancy and after birth will be determined in an observational study. Serial evaluations of depressive and anxiety symptoms and side effects will be obtained to evaluate their association with plasma concentrations at monthly intervals during pregnancy and twice post-birth. To assess the subjects' metabolic phenotypes, subjects have the option to receive a probe drug cocktail, which will be given to evaluate the activities of enzymes involved in antidepressant metabolism during the third trimester (when activity change is maximal) compared to the non-pregnant state after birth.

    Additionally, the study team will investigate the impact of genomic variability on inter-individual differences in SSRI dosing, plasma concentrations and pharmacodynamics during pregnancy, with a focus on genes involved in the metabolism and elimination of SSRIs, drug transporters responsible for SSRI access to the central nervous system, and genes encoding critical SSRI targets involved in therapeutic efficacy.

    Finally, the study team will determine the maternal-fetal plasma concentrations and pharmacogenetic characteristics associated with neonatal SSRI abstinence syndrome. Maternal and fetal genotypes will be assessed for their relationship to SSRI drug concentrations and neonatal abstinence syndrome.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    88 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    Optimizing Medication Management for Mothers With Depression
    Actual Study Start Date :
    Aug 1, 2016
    Actual Primary Completion Date :
    Dec 1, 2020
    Actual Study Completion Date :
    Jun 30, 2021

    Outcome Measures

    Primary Outcome Measures

    1. Concentration-to-dose ratio of SSRI in plasma [Every 4 weeks in pregnancy, at delivery, and at 6 and 14 weeks postpartum]

    Secondary Outcome Measures

    1. Edinburgh Postnatal Depression Scale (EPDS) Scores [Every 4 weeks in pregnancy, at delivery, and at 6 and 14 weeks postpartum]

    2. Asberg Side Effects Scale [Every 4 weeks in pregnancy and at 6 and 14 weeks postpartum]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 45 Years
    Sexes Eligible for Study:
    Female
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • Age 18-45

    • Pregnant, less than or at 18 weeks gestation

    • English-speaking

    • DSM-IV diagnosis of Major Depressive Disorder (MDD), any subtype

    • Medically healthy

    • Singleton gestation

    • Taking sertraline (Zoloft), fluoxetine (Prozac), or citalopram (Celexa)/escitalopram (Lexapro) and have made the decision to continue this medication throughout pregnancy

    Exclusion Criteria:
    • DSM-IV diagnosis of bipolar disorder or any psychotic episode

    • Substance abuse or dependence in the last 6 months and/or positive urine drug screen

    • Primary anxiety disorder without MDD

    • EPDS score ≥15, or item 10, self-harm thoughts, is scored 3 "yes, quite often"

    • Current use of other therapies for depression, including herbals (such as St. John's Wort)

    • Chronic use of drugs for medical disorders except aspirin

    • Allergy or adverse reaction to dextromethorphan, omeprazole, midazolam or tolbutamide (exclusion for probe study only; these individuals may still participate in the main study)

    Contacts and Locations

    Locations

    SiteCityStateCountryPostal Code
    1Northwestern University Asher Center for the Study and Treatment of Depressive DisordersChicagoIllinoisUnited States60611
    2University of PittsburghPittsburghPennsylvaniaUnited States15213
    3University of Texas Medical BranchGalvestonTexasUnited States77555
    4Marshfield ClinicMarshfieldWisconsinUnited States

    Sponsors and Collaborators

    • Northwestern University
    • University of Pittsburgh
    • The University of Texas Medical Branch, Galveston
    • Marshfield Clinic

    Investigators

    • Principal Investigator: Katherine L. Wisner, M.D., M.S., Northwestern University

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Katherine Wisner, Professor, Northwestern University
    ClinicalTrials.gov Identifier:
    NCT02519790
    Other Study ID Numbers:
    • 1U54HD085601-01
    First Posted:
    Aug 11, 2015
    Last Update Posted:
    Nov 17, 2021
    Last Verified:
    Nov 1, 2021
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Katherine Wisner, Professor, Northwestern University
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Nov 17, 2021