COD2017: The Effects of Intake of Protein From Cod Fillet and Cod Residual Material on Lipid Regulation, Glucose Regulation and Inflammation in Overweight or Obese Adults.
Study Details
Study Description
Brief Summary
A high intake of fish is associated with positive health effects, including prevention and treatment of chronic non-communicable diseases, such as cardiovascular diseases (CVDs) and type 2 diabetes. These health effects have traditionally been attributed to the omega-3 fatty acids in fatty fish, but recent studies have suggested that also fish proteins may improve biomarkers of metabolic disease. Intake of cod fillet have previously shown beneficial effects on blood lipids, glucose regulation and body composition in adults with overweight or obesity. Health effect of cod residual material from fillet production (i.e., head, backbone, skin, cutoffs and entrails) have so far not been investigated, but residuals from other fish species have shown promising effects on glucose regulation in rats. The main aim of the current study is to investigate the effects of protein from cod fillet and cod residuals on serum lipids, glucose regulation and inflammatory markers in healthy overweight or obese adults.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: Intact cod protein from fillet Dietary supplement: intact cod protein from fillet, 8 g protein daily for 8 weeks |
Dietary Supplement: Intact cod protein from fillet
Intact cod protein from fillet 8 g protein daily for 8 weeks
|
Experimental: Intact cod protein from residual material Dietary supplement: intact cod protein from residual material, 8 g protein daily for 8 weeks |
Dietary Supplement: Intact cod protein from residual material
Intact cod protein from residual material, 8 g protein daily for 8 weeks
|
Experimental: Control Control group receive tablet containing fillers and no proteins |
Dietary Supplement: Control
Control group receive tablet containing fillers
|
Outcome Measures
Primary Outcome Measures
- Biomarkers related to lipid metabolism [8 weeks]
Lipids will be measured in fasting serum samples
Secondary Outcome Measures
- Biomarkers related to glucose regulation [8 weeks]
Glucose, insulin and GLP-1 and will be measured in serum/plasma sampled in fasting and postprandial conditions.
- Inflammatory markers [8 weeks]
Cytokines will be measured in fasting serum/plasma
- Body composition [8 weeks]
Percent body fat will be measured using bioimpedance
Eligibility Criteria
Criteria
Inclusion Criteria:
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BMI ≥ 27 kg/m2
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Fasting blood glucose ≤7 mmol/L
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Physically inactive
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Percent body fat > 25 % for men and > 35 % for women
Exclusion Criteria:
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Allergies towards fish, milk, egg, gluten
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Tobacco use > 10 cigarettes (or snus) per day
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Diseases affecting the heart, intestinal function, kidney function or insulin secretion
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Medications targeting cholesterol -or glucose metabolism, hypertension
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Use of dietary supplements
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Pregnancy or lactation
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Oddrun Anita Gudbrandsen | Bergen | Norway | 5053 |
Sponsors and Collaborators
- University of Bergen
- The Research Council of Norway
- K. Halstensen AS
- Regional Research Fund Western Norway
- Nofima
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Drotningsvik A, Mjøs SA, Pampanin DM, Slizyte R, Carvajal A, Remman T, Høgøy I, Gudbrandsen OA. Dietary fish protein hydrolysates containing bioactive motifs affect serum and adipose tissue fatty acid compositions, serum lipids, postprandial glucose regulation and growth in obese Zucker fa/fa rats. Br J Nutr. 2016 Oct;116(8):1336-1345. Epub 2016 Oct 18.
- Vikøren LA, Nygård OK, Lied E, Rostrup E, Gudbrandsen OA. A randomised study on the effects of fish protein supplement on glucose tolerance, lipids and body composition in overweight adults. Br J Nutr. 2013 Feb 28;109(4):648-57. doi: 10.1017/S0007114512001717. Epub 2012 May 31.
- 2015/75 part 1