A Randomized Study of Olaparib or Placebo in Patients With Surgically Removed Pancreatic Cancer Who Have a BRCA1, BRCA2 or PALB2 Mutation, The APOLLO Trial
Study Details
Study Description
Brief Summary
This phase II trial investigates how well the addition of olaparib following completion of surgery and chemotherapy works in treating patients with pancreatic cancer that has been surgically removed (resected) and has a pathogenic mutation in BRCA1, BRCA2, or PALB2. Olaparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA) when it becomes damaged. Blocking PARP may help keep tumor cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 2 |
Detailed Description
PRIMARY OBJECTIVE:
- To determine the relapse-free survival (RFS)-benefit from the addition of a maintenance olaparib following completion of chemotherapy in patients with resected pancreatic carcinoma and a pathogenic germline or somatic mutation in BRCA1, BRCA2 or PALB2.
SECONDARY OBJECTIVES:
-
To evaluate RFS in patients with olaparib after perioperative chemotherapy compared to those treated with perioperative therapy alone among patients who received prior platinum-based perioperative chemotherapy.
-
To evaluate overall survival (OS) in patients treated with olaparib after adjuvant chemotherapy compared to those treated with adjuvant treatment alone.
-
To analyze the efficacy of olaparib after chemotherapy in patients with a pathogenic germline BRCA or PALB2 mutation compared to those with a somatic mutation.
-
To analyze survival differences between patients who received neoadjuvant or perioperative chemotherapy compared to those who received adjuvant therapy alone.
-
To analyze RFS and OS differences in those who received =< 3 months of perioperative platinum chemotherapy compared to those who received > 3 months of perioperative platinum chemotherapy.
-
To analyze RFS and OS differences in those who received any platinum-based perioperative chemotherapy compared to no-platinum based perioperative chemotherapy.
EXPLORATORY OBJECTIVES:
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To analyze RFS and OS differences in patients who had R1 versus (vs) R0 resections, lymph node positivity at resection, and/or elevated or rising CA 19-9 or CEA at time of study enrollment in the post-operative setting.
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To analyze RFS and OS differences with those who had resectable disease at diagnosis compared to those who did not.
-
To analyze RFS and OS differences in those with gBRCA1 mutations compared to those with gBRCA2 mutations and gPALB2 mutations.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM I: Patients receive olaparib orally (PO) twice daily (BID) on days 1-28. Treatment repeats every 28 days for 12 cycles in the absence of disease progression or unacceptable toxicity.
ARM II: Patients receive placebo PO BID on days 1-28. Treatment repeats every 28 days for 12 cycles in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up at 30 days, every 4 months for year 1, then every 6 months for years 2-10.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Arm I (olaparib) Patients receive olaparib PO BID on days 1-28. Treatment repeats every 28 days for 12 cycles in the absence of disease progression or unacceptable toxicity. |
Drug: Olaparib
Given PO
Other Names:
|
| Placebo Comparator: Arm II (placebo) Patients receive placebo PO BID on days 1-28. Treatment repeats every 28 days for 12 cycles in the absence of disease progression or unacceptable toxicity. |
Drug: Placebo Administration
Given PO
|
Outcome Measures
Primary Outcome Measures
- Improvement in relapse-free survival (RFS) [From randomization to first documentation of disease recurrence (primary tumor relapse) or death, assessed from 22 months to 44 months]
Will demonstrate an improvement in the RFS from 22 months to 44 months (hazard ratio 0.5) in patients treated with olaparib after perioperative (neoadjuvant, adjuvant or a combination) chemotherapy compared to those treated with perioperative therapy alone.
Secondary Outcome Measures
- RFS [From randomization to first documentation of disease recurrence (primary tumor relapse) or death, assessed up to 5 years]
Will evaluate RFS in patients with olaparib after perioperative chemotherapy compared to those treated with perioperative therapy alone. Analysis will be largely exploratory. Within each arm any proportion endpoint (toxicity, mutation rate, etc.) will be estimable with a 95% confidence interval. Arm A would have a confidence interval that is 20 percentage points wide, and Arm B would have a confidence interval that is 29 percentage points wide.
- Overall survival (OS) [From randomization until 10 years after registration or until death, whichever comes first]
Analysis will be largely exploratory. Power for overall survival in particular will be limited. Within each arm any proportion endpoint (toxicity, mutation rate, etc.) will be estimable with a 95% confidence interval. Arm A would have a confidence interval that is 20 percentage points wide, and Arm B would have a confidence interval that is 29 percentage points wide.
- Efficacy of olaparib after chemotherapy in patients with a pathogenic germline BRCA or PALB2 mutation [Up to 10 years]
Will analyze the efficacy of olaparib after chemotherapy in patients with a pathogenic germline BRCA or PALB2 mutation compared to those with a somatic mutation.
- Differences in survival [Up to 10 years]
Will analyze survival differences between patients who received neoadjuvant or perioperative chemotherapy compared to those who received adjuvant therapy alone.
- RFS in those who received =< 3 months of perioperative platinum chemotherapy compared to > 3 months of perioperative platinum chemotherapy [From randomization to first documentation of disease recurrence (primary tumor relapse) or death, assessed up to 5 years]
Analysis will be largely exploratory. Within each arm any proportion endpoint (toxicity, mutation rate, etc.) will be estimable with a 95% confidence interval. Arm A would have a confidence interval that is 20 percentage points wide, and Arm B would have a confidence interval that is 29 percentage points wide.
- OS in those who received =< 3 months of perioperative platinum chemotherapy versus > 3 months of perioperative platinum chemotherapy [From randomization until 10 years after registration or until death, whichever comes first]
Analysis will be largely exploratory. Power for overall survival in particular will be limited. Within each arm any proportion endpoint (toxicity, mutation rate, etc.) will be estimable with a 95% confidence interval. Arm A would have a confidence interval that is 20 percentage points wide, and Arm B would have a confidence interval that is 29 percentage points wide.
- RFS in those who received any platinum-based perioperative chemotherapy versus no platinum-based perioperative chemotherapy [From randomization to first documentation of disease recurrence (primary tumor relapse) or death, assessed up to 5 years]
Analysis will be largely exploratory. Within each arm any proportion endpoint (toxicity, mutation rate, etc.) will be estimable with a 95% confidence interval. Arm A would have a confidence interval that is 20 percentage points wide, and Arm B would have a confidence interval that is 29 percentage points wide.
- OS in those who received any platinum-based perioperative chemotherapy versus no platinum-based perioperative chemotherapy [From randomization until 10 years after registration or until death, whichever comes first]
Analysis will be largely exploratory. Power for overall survival in particular will be limited. Within each arm any proportion endpoint (toxicity, mutation rate, etc.) will be estimable with a 95% confidence interval. Arm A would have a confidence interval that is 20 percentage points wide, and Arm B would have a confidence interval that is 29 percentage points wide.
Other Outcome Measures
- RFS and OS differences in patients who had R1 vs R0 resections [At time of study enrollment]
- RFS and OS differences in patients who had lymph node positivity at resection [At time of study enrollment]
- RFS and OS differences in patients who had elevated or rising CA 19-9 or CEA [At time of study enrollment]
A cutoff of 35 will be used to determine elevated versus normal CA 19-9 (i.e., greater than 35 will be considered elevated), and the cutoff for CEA will be based on the treating institution's definition of the upper limit of normal. Univariate differences by marker status will be analyzed and Cox proportional hazards models will be fit, adjusting for other clinical and demographic factors that may be confounders.
- RFS and OS differences with those who had resectable disease at diagnosis [Up to 10 years]
Will be compared to those who did not.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
STEP 0 (PRE-REGISTRATION) INCLUSION CRITERIA
-
Patient must be >= 18 years of age on day of consent
-
Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
-
Patient must have a diagnosis of pancreatic cancer and have successfully undergone a curative intent surgical resection and must have no evidence of recurrent disease as determined by the investigator
-
NOTE: This includes patients with adenocarcinoma, acinar carcinoma, squamous cell carcinoma adenosquamous and variants thereof. Patients with neuroendocrine tumors are excluded from enrolling
-
Patient must (1) be planning to receive, (2) be receiving or (3) have received at least three combined months (i.e., 12 weeks) of perioperative (neoadjuvant, adjuvant or a combination of both) systemic, multi-agent chemotherapy. Patients may have had up to 6 months of perioperative systemic therapy as deemed appropriate by their primary treating medical team (patients can have received radiation or chemoradiation in addition to this 6 month course)
-
Patient must be no more than 12 weeks from their most recent treatment (this may be chemotherapy, radiotherapy or surgery)
-
Patient must have a known pathogenic or likely pathogenic germline or somatic mutation in BRCA1, BRCA2, or PALB2, as determined by a Clinical Laboratory Improvement Amendments (CLIA) certified or equivalently-accredited laboratory. Mutations must be considered pathogenic or likely pathogenic by a reference database such as ClinVar or OncoKb.org
-
STEP 1 (RANDOMIZATION) INCLUSION CRITERIA
-
Patient must have met the eligibility criteria outlined above
-
Patient must have undergone at least 3 combined months (i.e., 12 weeks) of perioperative (neoadjuvant, adjuvant or a combination of both) systemic, multi-agent chemotherapy. Patients may have had up to 6 months of perioperative systemic therapy as deemed appropriate by their primary treating medical team (patients can have received radiation or chemoradiation in addition to this 6 months course)
-
Central expert reviewer must have determined the patient eligible for randomization after review of local genetic testing reports
-
If mutation in BRCA1, BRCA2 or PALB2 was identified in tumor tissue and the patient has not previously undergone germline testing, the patient must agree to undergo germline testing
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Patient must not have previously had evidence of progressive pancreatic cancer while receiving platinum-based therapy
-
Patient must be >= 21 days (three weeks) from their last treatment (including chemotherapy radiotherapy or surgery) but =< 84 days (twelve weeks) from their last treatment at the time of Step 1 randomization. Patients who have received neoadjuvant and/or adjuvant radiotherapy are eligible
-
Patient must have recovered from any adverse events due to prior anti-cancer therapy (i.e., have no residual toxicities > grade 1 with the exception of alopecia and/or neuropathy)
-
Leukocytes >= 3,000/mcL (obtained =< 28 days prior to Step 1 randomization)
-
Absolute neutrophil count >= 1,500/mcL (obtained =< 28 days prior to Step 1 randomization)
-
Platelets >= 100,000/mcL (obtained =< 28 days prior to Step 1 randomization)
-
Hemoglobin >= 9.0 g/dL with no blood transfusion in the past 28 days (obtained =< 28 days prior to Step 1 randomization)
-
Total bilirubin =< institutional upper limit of normal (ULN) except in patients with Gilbert's syndrome. Patients with Gilbert's syndrome may enroll if direct bilirubin =< 2.5 ULN of the direct bilirubin (obtained =< 28 days prior to Step 1 randomization)
-
Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 institutional ULN (obtained =< 28 days prior to Step 1 randomization)
-
Creatinine =< institutional ULN OR calculated Cockcroft Gault creatinine clearance > 50 mL/min/1.73 m2 unless data exists supporting safe use at lower kidney function values, no lower than 30 mL/min/1.73 m2 (obtained =< 28 days prior to Step 1 randomization)
-
Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
-
For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated
-
Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
-
Patient must have the ability to understand the willingness to sign a written informed consent document, or have legally authorized representative provide authorization to participate
Exclusion Criteria:
-
STEP 1 (RANDOMIZATION) EXCLUSION CRITERIA
-
Patient must have no evidence of recurrent or metastatic pancreatic cancer at the time of randomization as documented by baseline scans obtained =< 4 weeks prior to Step 1 randomization
-
Patient must not be receiving any other investigational agents at the time of Step 1 randomization and while on protocol treatment
-
Patient must not have any history of allergic reactions attributed to compounds of similar chemical or biological composition to olaparib
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Patient must not have any personal history of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Patients with myelodysplastic syndrome/acute myeloid leukemia or with features suggestive of MDS/AML.
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Patient must not have any uncontrolled gastrointestinal disorder that would, in the opinion of the investigator, interfere with the ingestion or absorption of olaparib
-
Patient must not be pregnant or breast-feeding due the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used. All patients of childbearing potential must have a blood test or urine study within 14 days prior to Step 1 randomization to rule out pregnancy. A patient of childbearing potential is defined as anyone, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
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Patients must not expect to conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse for the duration of their participation in the study and for 6 months after the last dose of protocol treatment for female patients and for 3 months after the last dose of protocol treatment for male patients. Patients must also not donate sperm while on protocol treatment and for 3 months after the last dose of protocol treatment. Patients must also not breast-feed while on protocol treatment and for 1 month after the last dose of protocol treatment
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Patient must not have resting electrocardiogram (ECG) indicating uncontrolled, potentially reversible cardiac conditions, as judged by the investigator (e.g. unstable ischemia, uncontrolled symptomatic arrhythmia, congestive heart failure, corrected QT (QTc) prolongation > 500 ms, electrolyte disturbances, etc.) or have congenital long QT syndrome
-
Concomitant use of known potent CYP3A4/5 inhibitors such as ketoconazole, itraconazole, ritonavir, indinavir, saquinavir, telithromycin, clarithromycin and nelfinavir is prohibited
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Patients who are being actively treated for an ongoing concurrent malignancy are ineligible, with the exception of those receiving adjuvant hormone therapies and those receiving topical therapies for skin cancers
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Patient must not have, in the opinion of the investigator, any other concurrent medical condition that would prevent the patient from complying with the study procedures
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Patient must not be considered a poor medical risk due to a serious, uncontrolled medical disorder, non-malignant systemic disease or active, uncontrolled infection. Examples include, but are not limited to, uncontrolled ventricular arrhythmia, recent (within 3 months) myocardial infarction, uncontrolled major seizure disorder, unstable spinal cord compression, superior vena cava syndrome, extensive interstitial bilateral lung disease on high resolution computed tomography (HRCT) scan or any psychiatric disorder that prohibits obtaining informed consent
-
Patient must not have had major surgery within 2 weeks prior to randomization and patients must have recovered from any effects of any major surgery
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Anchorage Associates in Radiation Medicine | Anchorage | Alaska | United States | 98508 |
| 2 | Anchorage Radiation Therapy Center | Anchorage | Alaska | United States | 99504 |
| 3 | Alaska Breast Care and Surgery LLC | Anchorage | Alaska | United States | 99508 |
| 4 | Alaska Oncology and Hematology LLC | Anchorage | Alaska | United States | 99508 |
| 5 | Alaska Women's Cancer Care | Anchorage | Alaska | United States | 99508 |
| 6 | Anchorage Oncology Centre | Anchorage | Alaska | United States | 99508 |
| 7 | Katmai Oncology Group | Anchorage | Alaska | United States | 99508 |
| 8 | Providence Alaska Medical Center | Anchorage | Alaska | United States | 99508 |
| 9 | Fairbanks Memorial Hospital | Fairbanks | Alaska | United States | 99701 |
| 10 | Kingman Regional Medical Center | Kingman | Arizona | United States | 86401 |
| 11 | Cancer Center at Saint Joseph's | Phoenix | Arizona | United States | 85004 |
| 12 | Mercy Hospital Fort Smith | Fort Smith | Arkansas | United States | 72903 |
| 13 | CHI Saint Vincent Cancer Center Hot Springs | Hot Springs | Arkansas | United States | 71913 |
| 14 | Mission Hope Medical Oncology - Arroyo Grande | Arroyo Grande | California | United States | 93420 |
| 15 | PCR Oncology | Arroyo Grande | California | United States | 93420 |
| 16 | Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California | United States | 91505 |
| 17 | Pacific Central Coast Health Center-San Luis Obispo | San Luis Obispo | California | United States | 93401 |
| 18 | Mission Hope Medical Oncology - Santa Maria | Santa Maria | California | United States | 93444 |
| 19 | Northbay Cancer Center | Vacaville | California | United States | 95687 |
| 20 | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | United States | 80907 |
| 21 | Rocky Mountain Cancer Centers-Penrose | Colorado Springs | Colorado | United States | 80907 |
| 22 | Porter Adventist Hospital | Denver | Colorado | United States | 80210 |
| 23 | Mercy Medical Center | Durango | Colorado | United States | 81301 |
| 24 | Southwest Oncology PC | Durango | Colorado | United States | 81301 |
| 25 | Saint Anthony Hospital | Lakewood | Colorado | United States | 80228 |
| 26 | Littleton Adventist Hospital | Littleton | Colorado | United States | 80122 |
| 27 | Longmont United Hospital | Longmont | Colorado | United States | 80501 |
| 28 | Rocky Mountain Cancer Centers-Longmont | Longmont | Colorado | United States | 80501 |
| 29 | Parker Adventist Hospital | Parker | Colorado | United States | 80138 |
| 30 | Saint Mary Corwin Medical Center | Pueblo | Colorado | United States | 81004 |
| 31 | AdventHealth Altamonte | Altamonte Springs | Florida | United States | 32701 |
| 32 | AdventHealth Celebration | Celebration | Florida | United States | 34747 |
| 33 | UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida | United States | 33146 |
| 34 | UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | United States | 33442 |
| 35 | AdventHealth Kissimmee | Kissimmee | Florida | United States | 34744 |
| 36 | University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | United States | 33136 |
| 37 | UM Sylvester Comprehensive Cancer Center at Kendall | Miami | Florida | United States | 33176 |
| 38 | AdventHealth Medical Group Urology at Orlando | Orlando | Florida | United States | 32803 |
| 39 | AdventHealth Orlando | Orlando | Florida | United States | 32803 |
| 40 | AdventHealth East Orlando | Orlando | Florida | United States | 32822 |
| 41 | UM Sylvester Comprehensive Cancer Center at Plantation | Plantation | Florida | United States | 33324 |
| 42 | AdventHealth Winter Park | Winter Park | Florida | United States | 32792 |
| 43 | Emory University Hospital Midtown | Atlanta | Georgia | United States | 30308 |
| 44 | Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | United States | 30322 |
| 45 | Emory Saint Joseph's Hospital | Atlanta | Georgia | United States | 30342 |
| 46 | Saint Luke's Cancer Institute - Boise | Boise | Idaho | United States | 83712 |
| 47 | Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | United States | 83619 |
| 48 | Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | United States | 83642 |
| 49 | Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | United States | 83686 |
| 50 | Saint Luke's Cancer Institute - Twin Falls | Twin Falls | Idaho | United States | 83301 |
| 51 | Saint Anthony's Health | Alton | Illinois | United States | 62002 |
| 52 | Rush - Copley Medical Center | Aurora | Illinois | United States | 60504 |
| 53 | Illinois CancerCare-Bloomington | Bloomington | Illinois | United States | 61704 |
| 54 | Illinois CancerCare-Canton | Canton | Illinois | United States | 61520 |
| 55 | Memorial Hospital of Carbondale | Carbondale | Illinois | United States | 62902 |
| 56 | SIH Cancer Institute | Carterville | Illinois | United States | 62918 |
| 57 | Illinois CancerCare-Carthage | Carthage | Illinois | United States | 62321 |
| 58 | Centralia Oncology Clinic | Centralia | Illinois | United States | 62801 |
| 59 | University of Chicago Comprehensive Cancer Center | Chicago | Illinois | United States | 60637 |
| 60 | Carle on Vermilion | Danville | Illinois | United States | 61832 |
| 61 | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | United States | 62526 |
| 62 | Decatur Memorial Hospital | Decatur | Illinois | United States | 62526 |
| 63 | Illinois CancerCare-Dixon | Dixon | Illinois | United States | 61021 |
| 64 | Carle Physician Group-Effingham | Effingham | Illinois | United States | 62401 |
| 65 | Crossroads Cancer Center | Effingham | Illinois | United States | 62401 |
| 66 | Elmhurst Memorial Hospital | Elmhurst | Illinois | United States | 60126 |
| 67 | Illinois CancerCare-Eureka | Eureka | Illinois | United States | 61530 |
| 68 | Illinois CancerCare-Galesburg | Galesburg | Illinois | United States | 61401 |
| 69 | Western Illinois Cancer Treatment Center | Galesburg | Illinois | United States | 61401 |
| 70 | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | United States | 61443 |
| 71 | Illinois CancerCare-Macomb | Macomb | Illinois | United States | 61455 |
| 72 | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | United States | 61938 |
| 73 | Good Samaritan Regional Health Center | Mount Vernon | Illinois | United States | 62864 |
| 74 | Edward Hospital/Cancer Center | Naperville | Illinois | United States | 60540 |
| 75 | UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | United States | 60451 |
| 76 | Cancer Care Center of O'Fallon | O'Fallon | Illinois | United States | 62269 |
| 77 | University of Chicago Medicine-Orland Park | Orland Park | Illinois | United States | 60462 |
| 78 | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | United States | 61350 |
| 79 | Illinois CancerCare-Pekin | Pekin | Illinois | United States | 61554 |
| 80 | Illinois CancerCare-Peoria | Peoria | Illinois | United States | 61615 |
| 81 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 82 | Illinois CancerCare-Peru | Peru | Illinois | United States | 61354 |
| 83 | Valley Radiation Oncology | Peru | Illinois | United States | 61354 |
| 84 | Edward Hospital/Cancer Center?Plainfield | Plainfield | Illinois | United States | 60585 |
| 85 | Illinois CancerCare-Princeton | Princeton | Illinois | United States | 61356 |
| 86 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62702 |
| 87 | Springfield Clinic | Springfield | Illinois | United States | 62702 |
| 88 | Memorial Medical Center | Springfield | Illinois | United States | 62781 |
| 89 | Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 90 | The Carle Foundation Hospital | Urbana | Illinois | United States | 61801 |
| 91 | Illinois CancerCare - Washington | Washington | Illinois | United States | 61571 |
| 92 | Rush-Copley Healthcare Center | Yorkville | Illinois | United States | 60560 |
| 93 | Northwest Cancer Center - Main Campus | Crown Point | Indiana | United States | 46307 |
| 94 | Northwest Oncology LLC | Dyer | Indiana | United States | 46311 |
| 95 | Saint Mary Medical Center | Hobart | Indiana | United States | 46342 |
| 96 | The Community Hospital | Munster | Indiana | United States | 46321 |
| 97 | Memorial Hospital of South Bend | South Bend | Indiana | United States | 46601 |
| 98 | Mary Greeley Medical Center | Ames | Iowa | United States | 50010 |
| 99 | McFarland Clinic PC - Ames | Ames | Iowa | United States | 50010 |
| 100 | McFarland Clinic PC-Boone | Boone | Iowa | United States | 50036 |
| 101 | Saint Anthony Regional Hospital | Carroll | Iowa | United States | 51401 |
| 102 | Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa | United States | 50325 |
| 103 | Mercy Cancer Center-West Lakes | Clive | Iowa | United States | 50325 |
| 104 | Alegent Health Mercy Hospital | Council Bluffs | Iowa | United States | 51503 |
| 105 | Greater Regional Medical Center | Creston | Iowa | United States | 50801 |
| 106 | Iowa Methodist Medical Center | Des Moines | Iowa | United States | 50309 |
| 107 | Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa | United States | 50309 |
| 108 | Broadlawns Medical Center | Des Moines | Iowa | United States | 50314 |
| 109 | Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa | United States | 50314 |
| 110 | Mercy Medical Center - Des Moines | Des Moines | Iowa | United States | 50314 |
| 111 | Iowa Lutheran Hospital | Des Moines | Iowa | United States | 50316 |
| 112 | McFarland Clinic PC-Trinity Cancer Center | Fort Dodge | Iowa | United States | 50501 |
| 113 | Trinity Regional Medical Center | Fort Dodge | Iowa | United States | 50501 |
| 114 | McFarland Clinic PC-Jefferson | Jefferson | Iowa | United States | 50129 |
| 115 | McFarland Clinic PC-Marshalltown | Marshalltown | Iowa | United States | 50158 |
| 116 | Methodist West Hospital | West Des Moines | Iowa | United States | 50266-7700 |
| 117 | Mercy Medical Center-West Lakes | West Des Moines | Iowa | United States | 50266 |
| 118 | University of Kansas Clinical Research Center | Fairway | Kansas | United States | 66205 |
| 119 | Central Care Cancer Center - Garden City | Garden City | Kansas | United States | 67846 |
| 120 | Central Care Cancer Center - Great Bend | Great Bend | Kansas | United States | 67530 |
| 121 | HaysMed University of Kansas Health System | Hays | Kansas | United States | 67601 |
| 122 | University of Kansas Cancer Center | Kansas City | Kansas | United States | 66160 |
| 123 | Lawrence Memorial Hospital | Lawrence | Kansas | United States | 66044 |
| 124 | Olathe Health Cancer Center | Olathe | Kansas | United States | 66061 |
| 125 | University of Kansas Cancer Center-Overland Park | Overland Park | Kansas | United States | 66210 |
| 126 | University of Kansas Hospital-Indian Creek Campus | Overland Park | Kansas | United States | 66211 |
| 127 | Ascension Via Christi - Pittsburg | Pittsburg | Kansas | United States | 66762 |
| 128 | Salina Regional Health Center | Salina | Kansas | United States | 67401 |
| 129 | University of Kansas Health System Saint Francis Campus | Topeka | Kansas | United States | 66606 |
| 130 | University of Kansas Hospital-Westwood Cancer Center | Westwood | Kansas | United States | 66205 |
| 131 | Flaget Memorial Hospital | Bardstown | Kentucky | United States | 40004 |
| 132 | Commonwealth Cancer Center-Corbin | Corbin | Kentucky | United States | 40701 |
| 133 | Saint Joseph Radiation Oncology Resource Center | Lexington | Kentucky | United States | 40504 |
| 134 | Saint Joseph Hospital East | Lexington | Kentucky | United States | 40509 |
| 135 | Saint Joseph London | London | Kentucky | United States | 40741 |
| 136 | Jewish Hospital | Louisville | Kentucky | United States | 40202 |
| 137 | Saints Mary and Elizabeth Hospital | Louisville | Kentucky | United States | 40215 |
| 138 | UofL Health Medical Center Northeast | Louisville | Kentucky | United States | 40245 |
| 139 | Jewish Hospital Medical Center South | Shepherdsville | Kentucky | United States | 40165 |
| 140 | Hickman Cancer Center | Adrian | Michigan | United States | 49221 |
| 141 | Saint Joseph Mercy Hospital | Ann Arbor | Michigan | United States | 48106 |
| 142 | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | United States | 48109 |
| 143 | Saint Joseph Mercy Brighton | Brighton | Michigan | United States | 48114 |
| 144 | Trinity Health IHA Medical Group Hematology Oncology - Brighton | Brighton | Michigan | United States | 48114 |
| 145 | Saint Joseph Mercy Canton | Canton | Michigan | United States | 48188 |
| 146 | Trinity Health IHA Medical Group Hematology Oncology - Canton | Canton | Michigan | United States | 48188 |
| 147 | Saint Joseph Mercy Chelsea | Chelsea | Michigan | United States | 48118 |
| 148 | Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital | Chelsea | Michigan | United States | 48118 |
| 149 | Ascension Saint John Hospital | Detroit | Michigan | United States | 48236 |
| 150 | Great Lakes Cancer Management Specialists-Doctors Park | East China Township | Michigan | United States | 48054 |
| 151 | Genesee Cancer and Blood Disease Treatment Center | Flint | Michigan | United States | 48503 |
| 152 | Genesee Hematology Oncology PC | Flint | Michigan | United States | 48503 |
| 153 | Genesys Hurley Cancer Institute | Flint | Michigan | United States | 48503 |
| 154 | Academic Hematology Oncology Specialists | Grosse Pointe Woods | Michigan | United States | 48236 |
| 155 | Great Lakes Cancer Management Specialists-Van Elslander Cancer Center | Grosse Pointe Woods | Michigan | United States | 48236 |
| 156 | Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | United States | 48154 |
| 157 | Great Lakes Cancer Management Specialists-Macomb Medical Campus | Macomb | Michigan | United States | 48044 |
| 158 | Toledo Clinic Cancer Centers-Monroe | Monroe | Michigan | United States | 48162 |
| 159 | Ascension Providence Hospitals - Novi | Novi | Michigan | United States | 48374 |
| 160 | Ascension Providence Hospitals - Southfield | Southfield | Michigan | United States | 48075 |
| 161 | Bhadresh Nayak MD PC-Sterling Heights | Sterling Heights | Michigan | United States | 48312 |
| 162 | Great Lakes Cancer Management Specialists-Macomb Professional Building | Warren | Michigan | United States | 48093 |
| 163 | Saint John Macomb-Oakland Hospital | Warren | Michigan | United States | 48093 |
| 164 | Huron Gastroenterology PC | Ypsilanti | Michigan | United States | 48106 |
| 165 | Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus | Ypsilanti | Michigan | United States | 48197 |
| 166 | Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | United States | 56601 |
| 167 | Saint Luke's Hospital of Duluth | Duluth | Minnesota | United States | 55805 |
| 168 | Abbott-Northwestern Hospital | Minneapolis | Minnesota | United States | 55407 |
| 169 | Mayo Clinic in Rochester | Rochester | Minnesota | United States | 55905 |
| 170 | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | United States | 55416 |
| 171 | Regions Hospital | Saint Paul | Minnesota | United States | 55101 |
| 172 | Saint Louis Cancer and Breast Institute-Ballwin | Ballwin | Missouri | United States | 63011 |
| 173 | Central Care Cancer Center - Bolivar | Bolivar | Missouri | United States | 65613 |
| 174 | Saint Francis Medical Center | Cape Girardeau | Missouri | United States | 63703 |
| 175 | Southeast Cancer Center | Cape Girardeau | Missouri | United States | 63703 |
| 176 | Parkland Health Center - Farmington | Farmington | Missouri | United States | 63640 |
| 177 | Capital Region Southwest Campus | Jefferson City | Missouri | United States | 65109 |
| 178 | Freeman Health System | Joplin | Missouri | United States | 64804 |
| 179 | Mercy Hospital Joplin | Joplin | Missouri | United States | 64804 |
| 180 | Truman Medical Centers | Kansas City | Missouri | United States | 64108 |
| 181 | University of Kansas Cancer Center - North | Kansas City | Missouri | United States | 64154 |
| 182 | University of Kansas Cancer Center - Lee's Summit | Lee's Summit | Missouri | United States | 64064 |
| 183 | University of Kansas Cancer Center at North Kansas City Hospital | North Kansas City | Missouri | United States | 64116 |
| 184 | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | United States | 65401 |
| 185 | Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | United States | 65401 |
| 186 | Heartland Regional Medical Center | Saint Joseph | Missouri | United States | 64506 |
| 187 | Saint Louis Cancer and Breast Institute-South City | Saint Louis | Missouri | United States | 63109 |
| 188 | Mercy Hospital South | Saint Louis | Missouri | United States | 63128 |
| 189 | Missouri Baptist Medical Center | Saint Louis | Missouri | United States | 63131 |
| 190 | Mercy Hospital Saint Louis | Saint Louis | Missouri | United States | 63141 |
| 191 | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | United States | 63670 |
| 192 | Mercy Hospital Springfield | Springfield | Missouri | United States | 65804 |
| 193 | CoxHealth South Hospital | Springfield | Missouri | United States | 65807 |
| 194 | Missouri Baptist Sullivan Hospital | Sullivan | Missouri | United States | 63080 |
| 195 | Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri | United States | 63127 |
| 196 | Mercy Hospital Washington | Washington | Missouri | United States | 63090 |
| 197 | Saint Patrick Hospital - Community Hospital | Missoula | Montana | United States | 59802 |
| 198 | CHI Health Saint Francis | Grand Island | Nebraska | United States | 68803 |
| 199 | CHI Health Good Samaritan | Kearney | Nebraska | United States | 68847 |
| 200 | Saint Elizabeth Regional Medical Center | Lincoln | Nebraska | United States | 68510 |
| 201 | Alegent Health Immanuel Medical Center | Omaha | Nebraska | United States | 68122 |
| 202 | Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska | United States | 68124 |
| 203 | Alegent Health Lakeside Hospital | Omaha | Nebraska | United States | 68130 |
| 204 | Creighton University Medical Center | Omaha | Nebraska | United States | 68131 |
| 205 | Midlands Community Hospital | Papillion | Nebraska | United States | 68046 |
| 206 | Carson Tahoe Regional Medical Center | Carson City | Nevada | United States | 89703 |
| 207 | Cancer and Blood Specialists-Henderson | Henderson | Nevada | United States | 89052 |
| 208 | Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada | United States | 89052 |
| 209 | Comprehensive Cancer Centers of Nevada-Horizon Ridge | Henderson | Nevada | United States | 89052 |
| 210 | Las Vegas Cancer Center-Henderson | Henderson | Nevada | United States | 89052 |
| 211 | OptumCare Cancer Care at Seven Hills | Henderson | Nevada | United States | 89052 |
| 212 | Comprehensive Cancer Centers of Nevada-Southeast Henderson | Henderson | Nevada | United States | 89074 |
| 213 | GenesisCare USA - Henderson | Henderson | Nevada | United States | 89074 |
| 214 | Las Vegas Urology - Green Valley | Henderson | Nevada | United States | 89074 |
| 215 | Las Vegas Urology - Pebble | Henderson | Nevada | United States | 89074 |
| 216 | Urology Specialists of Nevada - Green Valley | Henderson | Nevada | United States | 89074 |
| 217 | Las Vegas Urology - Pecos | Las Vegas | Nevada | United States | 89074 |
| 218 | Desert West Surgery | Las Vegas | Nevada | United States | 89102 |
| 219 | OptumCare Cancer Care at Charleston | Las Vegas | Nevada | United States | 89102 |
| 220 | University Medical Center of Southern Nevada | Las Vegas | Nevada | United States | 89102 |
| 221 | Hope Cancer Care of Nevada | Las Vegas | Nevada | United States | 89103 |
| 222 | Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada | United States | 89106 |
| 223 | Urology Specialists of Nevada - Central | Las Vegas | Nevada | United States | 89106 |
| 224 | GenesisCare USA - Las Vegas | Las Vegas | Nevada | United States | 89109 |
| 225 | Sunrise Hospital and Medical Center | Las Vegas | Nevada | United States | 89109 |
| 226 | Las Vegas Prostate Cancer Center | Las Vegas | Nevada | United States | 89113 |
| 227 | Las Vegas Urology - Sunset | Las Vegas | Nevada | United States | 89113 |
| 228 | Urology Specialists of Nevada - Southwest | Las Vegas | Nevada | United States | 89113 |
| 229 | Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada | United States | 89119 |
| 230 | Ann M Wierman MD LTD | Las Vegas | Nevada | United States | 89128 |
| 231 | Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada | United States | 89128 |
| 232 | GenesisCare USA - Vegas Tenaya | Las Vegas | Nevada | United States | 89128 |
| 233 | Las Vegas Urology - Cathedral Rock | Las Vegas | Nevada | United States | 89128 |
| 234 | Las Vegas Urology - Smoke Ranch | Las Vegas | Nevada | United States | 89128 |
| 235 | OptumCare Cancer Care at MountainView | Las Vegas | Nevada | United States | 89128 |
| 236 | Urology Specialists of Nevada - Northwest | Las Vegas | Nevada | United States | 89128 |
| 237 | Alliance for Childhood Diseases/Cure 4 the Kids Foundation | Las Vegas | Nevada | United States | 89135 |
| 238 | Comprehensive Cancer Centers of Nevada - Town Center | Las Vegas | Nevada | United States | 89144 |
| 239 | Comprehensive Cancer Centers of Nevada-Summerlin | Las Vegas | Nevada | United States | 89144 |
| 240 | Summerlin Hospital Medical Center | Las Vegas | Nevada | United States | 89144 |
| 241 | Las Vegas Cancer Center-Medical Center | Las Vegas | Nevada | United States | 89148-2405 |
| 242 | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | United States | 89148 |
| 243 | GenesisCare USA - Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 244 | OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 245 | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada | United States | 89169 |
| 246 | University Cancer Center | Las Vegas | Nevada | United States | 89169 |
| 247 | Hope Cancer Care of Nevada-Pahrump | Pahrump | Nevada | United States | 89048 |
| 248 | Renown Regional Medical Center | Reno | Nevada | United States | 89502 |
| 249 | Saint Mary's Regional Medical Center | Reno | Nevada | United States | 89503 |
| 250 | Radiation Oncology Associates | Reno | Nevada | United States | 89509 |
| 251 | Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | United States | 03756 |
| 252 | Memorial Sloan Kettering Basking Ridge | Basking Ridge | New Jersey | United States | 07920 |
| 253 | Cooper Hospital University Medical Center | Camden | New Jersey | United States | 08103 |
| 254 | Memorial Sloan Kettering Monmouth | Middletown | New Jersey | United States | 07748 |
| 255 | Memorial Sloan Kettering Bergen | Montvale | New Jersey | United States | 07645 |
| 256 | Holy Name Hospital | Teaneck | New Jersey | United States | 07666 |
| 257 | MD Anderson Cancer Center at Cooper-Voorhees | Voorhees | New Jersey | United States | 08043 |
| 258 | University of New Mexico Cancer Center | Albuquerque | New Mexico | United States | 87102 |
| 259 | Memorial Sloan Kettering Commack | Commack | New York | United States | 11725 |
| 260 | Memorial Sloan Kettering Westchester | Harrison | New York | United States | 10604 |
| 261 | Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York | United States | 10016 |
| 262 | Memorial Sloan Kettering Cancer Center | New York | New York | United States | 10065 |
| 263 | Memorial Sloan Kettering Nassau | Uniondale | New York | United States | 11553 |
| 264 | Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina | United States | 28328 |
| 265 | Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina | United States | 27534 |
| 266 | Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina | United States | 28546 |
| 267 | Sanford Bismarck Medical Center | Bismarck | North Dakota | United States | 58501 |
| 268 | Sanford Broadway Medical Center | Fargo | North Dakota | United States | 58122 |
| 269 | Sanford Roger Maris Cancer Center | Fargo | North Dakota | United States | 58122 |
| 270 | Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio | United States | 45220 |
| 271 | Bethesda North Hospital | Cincinnati | Ohio | United States | 45242 |
| 272 | TriHealth Cancer Institute-Westside | Cincinnati | Ohio | United States | 45247 |
| 273 | TriHealth Cancer Institute-Anderson | Cincinnati | Ohio | United States | 45255 |
| 274 | Mercy Health - Saint Anne Hospital | Toledo | Ohio | United States | 43623 |
| 275 | Toledo Clinic Cancer Centers-Toledo | Toledo | Ohio | United States | 43623 |
| 276 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 277 | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | United States | 73120 |
| 278 | Saint Charles Health System | Bend | Oregon | United States | 97701 |
| 279 | Clackamas Radiation Oncology Center | Clackamas | Oregon | United States | 97015 |
| 280 | Providence Cancer Institute Clackamas Clinic | Clackamas | Oregon | United States | 97015 |
| 281 | Bay Area Hospital | Coos Bay | Oregon | United States | 97420 |
| 282 | Providence Newberg Medical Center | Newberg | Oregon | United States | 97132 |
| 283 | Providence Portland Medical Center | Portland | Oregon | United States | 97213 |
| 284 | Providence Saint Vincent Medical Center | Portland | Oregon | United States | 97225 |
| 285 | Saint Charles Health System-Redmond | Redmond | Oregon | United States | 97756 |
| 286 | Bryn Mawr Hospital | Bryn Mawr | Pennsylvania | United States | 19010 |
| 287 | Main Line Health Center-Collegeville | Collegeville | Pennsylvania | United States | 19426 |
| 288 | Main Line Health Center-Exton | Exton | Pennsylvania | United States | 19341 |
| 289 | Riddle Memorial Hospital | Media | Pennsylvania | United States | 19063 |
| 290 | Paoli Memorial Hospital | Paoli | Pennsylvania | United States | 19301 |
| 291 | University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania | United States | 19104 |
| 292 | Fox Chase Cancer Center | Philadelphia | Pennsylvania | United States | 19111 |
| 293 | Lankenau Medical Center | Wynnewood | Pennsylvania | United States | 19096 |
| 294 | Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | United States | 57104 |
| 295 | Avera Cancer Institute | Sioux Falls | South Dakota | United States | 57105 |
| 296 | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | United States | 57117-5134 |
| 297 | Saint Joseph Regional Cancer Center | Bryan | Texas | United States | 77802 |
| 298 | Farmington Health Center | Farmington | Utah | United States | 84025 |
| 299 | University of Utah Sugarhouse Health Center | Salt Lake City | Utah | United States | 84106 |
| 300 | Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | United States | 84112 |
| 301 | Norris Cotton Cancer Center-North | Saint Johnsbury | Vermont | United States | 05819 |
| 302 | Providence Regional Cancer System-Aberdeen | Aberdeen | Washington | United States | 98520 |
| 303 | MultiCare Auburn Medical Center | Auburn | Washington | United States | 98001 |
| 304 | Overlake Medical Center | Bellevue | Washington | United States | 98004 |
| 305 | PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | United States | 98225 |
| 306 | Harrison Medical Center | Bremerton | Washington | United States | 98310 |
| 307 | Highline Medical Center-Main Campus | Burien | Washington | United States | 98166 |
| 308 | Providence Regional Cancer System-Centralia | Centralia | Washington | United States | 98531 |
| 309 | Swedish Cancer Institute-Edmonds | Edmonds | Washington | United States | 98026 |
| 310 | Saint Elizabeth Hospital | Enumclaw | Washington | United States | 98022 |
| 311 | Providence Regional Cancer Partnership | Everett | Washington | United States | 98201 |
| 312 | Saint Francis Hospital | Federal Way | Washington | United States | 98003 |
| 313 | MultiCare Gig Harbor Medical Park | Gig Harbor | Washington | United States | 98335 |
| 314 | Swedish Cancer Institute-Issaquah | Issaquah | Washington | United States | 98029 |
| 315 | Kadlec Clinic Hematology and Oncology | Kennewick | Washington | United States | 99336 |
| 316 | Providence Regional Cancer System-Lacey | Lacey | Washington | United States | 98503 |
| 317 | Saint Clare Hospital | Lakewood | Washington | United States | 98499 |
| 318 | PeaceHealth Saint John Medical Center | Longview | Washington | United States | 98632 |
| 319 | MultiCare Good Samaritan Hospital | Puyallup | Washington | United States | 98372 |
| 320 | Valley Medical Center | Renton | Washington | United States | 98055 |
| 321 | Pacific Gynecology Specialists | Seattle | Washington | United States | 98104 |
| 322 | Swedish Medical Center-Ballard Campus | Seattle | Washington | United States | 98107 |
| 323 | Swedish Medical Center-First Hill | Seattle | Washington | United States | 98122-4307 |
| 324 | Swedish Medical Center-Cherry Hill | Seattle | Washington | United States | 98122-5711 |
| 325 | PeaceHealth United General Medical Center | Sedro-Woolley | Washington | United States | 98284 |
| 326 | Providence Regional Cancer System-Shelton | Shelton | Washington | United States | 98584 |
| 327 | MultiCare Deaconess Cancer and Blood Specialty Center - Valley | Spokane Valley | Washington | United States | 99216 |
| 328 | MultiCare Deaconess Cancer and Blood Specialty Center - Downtown | Spokane | Washington | United States | 99204 |
| 329 | MultiCare Deaconess Cancer and Blood Specialty Center - North | Spokane | Washington | United States | 99218 |
| 330 | Franciscan Research Center-Northwest Medical Plaza | Tacoma | Washington | United States | 98405 |
| 331 | MultiCare Tacoma General Hospital | Tacoma | Washington | United States | 98405 |
| 332 | PeaceHealth Southwest Medical Center | Vancouver | Washington | United States | 98664 |
| 333 | Providence Saint Mary Regional Cancer Center | Walla Walla | Washington | United States | 99362 |
| 334 | North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington | United States | 98902 |
| 335 | Providence Regional Cancer System-Yelm | Yelm | Washington | United States | 98597 |
| 336 | ThedaCare Regional Cancer Center | Appleton | Wisconsin | United States | 54911 |
| 337 | UW Cancer Center Johnson Creek | Johnson Creek | Wisconsin | United States | 53038 |
| 338 | Gundersen Lutheran Medical Center | La Crosse | Wisconsin | United States | 54601 |
| 339 | University of Wisconsin Carbone Cancer Center | Madison | Wisconsin | United States | 53792 |
| 340 | ProHealth D N Greenwald Center | Mukwonago | Wisconsin | United States | 53149 |
| 341 | ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | United States | 53066 |
| 342 | ProHealth Waukesha Memorial Hospital | Waukesha | Wisconsin | United States | 53188 |
| 343 | UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | United States | 53188 |
Sponsors and Collaborators
- National Cancer Institute (NCI)
Investigators
- Principal Investigator: Kim A Reiss Binder, ECOG-ACRIN Cancer Research Group
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NCI-2020-05659
- NCI-2020-05659
- EA2192
- EA2192
- U10CA180820