MPPN: Understanding Motivation in Parkinson's Patients Through Neurophysiology
Study Details
Study Description
Brief Summary
The study's aim is to better understand motivation and value-based decision making in Parkinson's patients through neurophysiology using Medtronic's Percept PC DBS device.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Detailed Description
The investigators will ask patients to complete reward-based decision making tasks in clinic and at home in the presence and absence of Percept PC deep brain stimulation and medication. The Percept PC device has the ability to stream data during paradigms and chronically at home. Patients at home will also be fitted with a wearable device which records motion, sleep, heart rate variability, and self-reported metrics. The investigators will use spectral techniques and statistical analysis to identify the relationship between brain signals and motivation.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: Stimulation Patients will be getting standard clinically acceptable stimulation within already safety validated stimulation ranges through their Medtronic Percept PC device. |
Other: Stimulation on
Stimulation from Percept PC DBS will be on while the patient is playing a decision-making game on a computer-based application.
Other Names:
Behavioral: Decision Making Task
Patients will be playing a decision making task through a computer-based application.
|
Experimental: No Stimulation Patients will have stimulation turned off through their Medtronic Percept PC device. |
Other: Stimulation off
Stimulation from Percept PC DBS will be off while the patient is playing a decision-making game on a computer-based application.
Other Names:
Behavioral: Decision Making Task
Patients will be playing a decision making task through a computer-based application.
|
Outcome Measures
Primary Outcome Measures
- Percent of Risky Decisions made with Percept PC DBS stimulation on for Parkinson's Disease Patients [The values will be collected starting from admission in clinic and the at-home paradigm. Data collection and analysis of said values can take up to three years]
Patients' responses on the tablet will be recorded in-clinic and at home. The investigators will tally their choices from the value-based decision making game (risky versus safe decisions) and report an average of risky responses.
- Percent of Risky Decisions made with Percept PC DBS stimulation off for Parkinson's Disease Patients [The values will be collected starting from admission in clinic and the at-home paradigm. Data collection and analysis of said values can take up to three years]
Patients' responses on the tablet will be recorded in-clinic and at home. The investigators will tally their choices from the value-based decision making game (risky versus safe decisions) and report an average of risky responses.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Has Parkinson's Disease
-
Has Medtronic Percept PC DBS device implanted in either GPI or STN
Exclusion Criteria:
- Severe cognitive impairments
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | University of California San Francisco | San Francisco | California | United States | 94158 |
Sponsors and Collaborators
- University of California, San Francisco
- Yale University
- Rune Labs
Investigators
- Principal Investigator: Simon J Little, MBBS, PhD, University of California, San Francisco
Study Documents (Full-Text)
None provided.More Information
Publications
- Blain B, Rutledge RB. Momentary subjective well-being depends on learning and not reward. Elife. 2020 Nov 17;9. pii: e57977. doi: 10.7554/eLife.57977.
- Eldar E, Rutledge RB, Dolan RJ, Niv Y. Mood as Representation of Momentum. Trends Cogn Sci. 2016 Jan;20(1):15-24. doi: 10.1016/j.tics.2015.07.010. Epub 2015 Nov 3. Review.
- Rutledge RB, Skandali N, Dayan P, Dolan RJ. A computational and neural model of momentary subjective well-being. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12252-7. doi: 10.1073/pnas.1407535111. Epub 2014 Aug 4.
- Rutledge RB, Skandali N, Dayan P, Dolan RJ. Dopaminergic Modulation of Decision Making and Subjective Well-Being. J Neurosci. 2015 Jul 8;35(27):9811-22. doi: 10.1523/JNEUROSCI.0702-15.2015.
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