MAPT Haploid H1b and the Damage of BBB in Dorsal Medulla Oblongata and Autonomic Dysfunction in PD
This study mainly explored the relationship between the permeability of the blood-brain barrier in the dorsal medulla oblongata and autonomic dysfunction, and the relationship and mechanism of MAPT genotype on the permeability of the blood-brain barrier and the progression of autonomic dysfunction in PD patients.
|Condition or Disease||Intervention/Treatment||Phase|
According to the MDS 2015 clinical diagnostic criteria for Parkinson's disease and the diagnostic criteria for autonomic dysfunction (AutD), the patients were divided into PD with AutD group and PD without AutD group. DCE results, pet-pdrp+18f-dopa data and clinical evaluation (SCOPA-AUT, HRV and sleep EEG) were analyzed; Blood samples were collected to detect MAPT gene polymorphism, oligomers and phosphorylated synuclein. To explore the relationship between the permeability of the blood-brain barrier in the dorsal medulla oblongata and autonomic dysfunction, and the relationship and mechanism of MAPT genotype on the permeability of the blood-brain barrier and the progression of autonomic dysfunction in PD patients.
Arms and Interventions
|PD with AutD
Parkinson's disease with autonomic dysfunction
Other: Autonomic dysfunction
|PD without AutD
Parkinson's disease without autonomic dysfunction
Primary Outcome Measures
- MAPT genotype [baseline]
MAPT mainly has two extended haplotypes (H1 and H2) .
- Dynamic changes of the permeability of blood-brain barrier in dorsal medulla oblongata [baseline,the sixth month,1year]
Dynamic contrast-enhanced MRI is used to measure the permeability of blood-brain barrier in dorsal medulla oblongata.Dynamic contrast ⁃ enhanced (DCE) ⁃ MRI is a very valuable quantitative MRI technology, which plays a great role in clinical research. Quantitative analysis can calculate the contrast agent concentration in the region of interest, and then improve the comparability of different research results. The permeability of blood-brain barrier is calculated by the volume transfer constant (Ktrans) between plasma and extravascular-extracellular space.
- Dynamic changes of SCOPA-AUT scale [baseline,the sixth month,1 year]
The Scales for Outcomes in Parkinson's Disease-Autonomic (SCOPA-AUT) is used to evaluate autonomic nerve dysfunction. The SCOPA-AUT consists of 25 items assessing the following regions: gastrointestinal (7), urinary (6), cardiovascular (3), thermoregulatory (4), pupillomotor (1), and sexual (2 items for men and 2 items for women) dysfunction.Higher scores mean more severe autonomic dysfunction, with a minimum score of 0 and a maximum of 69.
Meet the diagnostic criteria for idiopathic PD of MDS 2015
Age ≥ 45 years old
Be able to complete various clinical evaluations and scales; Willing to participate in MRI, no contrast agent allergy
Dementia was diagnosed before or 1 year after the onset of motor symptoms
Single gene form of PD
Coexisting neuropathological diagnosis considered to affect PD progression
Known complications affecting BBB (severe infection, cerebral infarction, etc.
Such as comorbidities known to affect the autonomic nervous system (e.g., diabetes gangliopathy or neuropathy)
Disturbance of consciousness, serious cerebral hemorrhage or cerebral thrombosis, serious brain tumor or brain surgery history, serious mental illness or other serious nervous system diseases, which are enough to seriously interfere with the subjects' motor and non motor symptoms
According to the judgment of the researcher, the researcher is unable to complete the research test according to the requirements of the research scheme.
Contacts and Locations
|1||Zhujiang Hospital of Southern Medical University||Guangzhou||Guangdong||China||510000|
Sponsors and Collaborators
- Zhujiang Hospital
- Principal Investigator: shuzhen zhu, doctor, Southern Medical University, China
Study Documents (Full-Text)None provided.