The Mechanism of Modified Utral-long Protocol in Improving Endometrial Receptivity in Patients With PCOS and IR
Study Details
Study Description
Brief Summary
NF-κB pathway activation-induced endometrial insulin resistance was one of the causes of infertility patients with PCOS and insulin resistance whose endometrial receptivity is declined .The investigators' previous findings indicated that the use of modified utral-long protocols ( GnRH-a was used twice in mid-luteal phaes) can improve clinical outcomes by improving endometrial receptivity in patients with PCOS , but the mechanism was not clear. Previous research also found that GnRH-a reduced the activity of NF-κB pathway in endometrial stromal cells and depended the dose and time.Thus, The investigators' subject will try to applicate GnRH-a to explore the influence of NF-κB pathway activity 、the state of insulin resistance and embryo implantation rate ;then we will investgate GnRH-a whether reduce NF-κB pathway activity-induced insulin resistance and ultimately improve endometrial receptivity by using GnRH-a in infertility patients with PCOS and insulin resistance.The investigators' research attempt to provide ideas for seeking inflammatory medication target in assisted reproductive technology in patients with PCOS by exploring the immune mechanism of GnRHa on improving the endometrial receptivity .
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Detailed Description
The endometrial biopsy was performed in the previous cycle of the protocol. According to the expression of NF-κB in the endometrium random group. The difference of NF - κB expression in patients with different protocol were compared.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: Experimental group Modified Supper Long Protocol |
Procedure: Modified Supper Long Protocol
In Modified Supper Long Protocol, GnRH-a was used twice in mid-luteal phaes
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No Intervention: control group long protocol |
Outcome Measures
Primary Outcome Measures
- clinical pregnancy rate [28 days after transplantation]
a beating heart tube was 99 detected by ultrasound examination
Eligibility Criteria
Criteria
Inclusion Criteria:
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age<36years,
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PCOS,
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Insulin resistance (HOMA-IR = fasting insulin (FINS) × fasting blood glucose (FPG) / 22.5, HOMA-IR ≥ 2.69 );
Exclusion Criteria:
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uterine abnormalities (double uterus, bicornuate uterus, unicornuate uterus and uterine mediastinum),
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intrauterine adhesions,
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endometriosis, adenomyosis,
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Hydrosalpinx,
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uterine fibroids (submucosal fibroids, non-mucosal fibroids > 4 cm and / or endometrial pressure),
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Hyroid dysfunction and hyperprolactinemia.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Reproductive & Genetic Hospital of CITIC-XIANGYA | Changsha | Hunan | China | 410008 |
Sponsors and Collaborators
- Reproductive & Genetic Hospital of CITIC-Xiangya
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 81501328