Bisphenol Role in the Pathogenesis of PCOS
Study Details
Study Description
Brief Summary
Polycystic ovary syndrome (PCOS) is the most common and the most heterogeneous endocrine disorder in premenopausal women. Its prevalence is estimated from 5 to 10% depending on the diagnosis' criteria .
Apart from signs of hyperandrogenism such as acne, hirsutism and hair loss; women with PCOS usually present with menstrual irregularities and fertility problems ..
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Bisphenol A is formed from acetone and phenol, it is used in production of epoxy resin, polyster resins and polyvarbonate resins. Epoxy resins are used in plastics, adhesives, and structural composites .
Humans are at the end of the food chain, thus they are exposed to the highest doses of these compounds. EDs have been detected in human adipose tissue and biological fluids such as: serum, urine, milk and amniotic fluid .
Additionally, it has been proven that BPA can also directly stimulate androgen synthesis in the ovarian theca-interstitial cells. A correlation between increased serum testosterone levels observed in women with PCOS with serum BPA concentrations has also been found .
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
PCOS group patients who have PCOS |
Diagnostic Test: Measurement of Bisphenol in urine
to see level of this material in blood of women
|
control group patients who donnot have PCOS |
Diagnostic Test: Measurement of Bisphenol in urine
to see level of this material in blood of women
|
Outcome Measures
Primary Outcome Measures
- the number of participants who will have high level of bisphenol in btheir blood [within 6 weeks]
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age group: 18-40
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Females
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Diagnosed a case of polycystic ovary syndrome
Exclusion Criteria:
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• Female patients with other acute or chronic illness
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Cardiovascular disease
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Neoplasms
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Current smoking, diabetes mellitus,
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Renal impairment (serum creatinine 120 mol/liter), and hypertension (blood pressure 140/85 mm Hg).
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Algazeerah | Giza | Egypt |
Sponsors and Collaborators
- Aljazeera Hospital
- Kasr El Aini Hospital
- Cairo University
Investigators
- Principal Investigator: Mahmoud Alalfy, Algazeerah hospital -Location (Giza -Egypt )
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Bisphenol and PCOS