PEEP Setting in COVID19-related ARDS
Study Details
Study Description
Brief Summary
The best way to titrate positive end-expiratory pressure (PEEP) in patients suffering from acute respiratory distress syndrome is still matter of debate. Electrical impedance tomography (EIT) in a non-invasive technique that could guide PEEP setting based on an optimized ventilation homogeneity.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
COVID-19 related ARDS patients admitted to the ICU in March 2021 requiring mechanical ventilation were enrolled. Patients were monitored by an esophageal catheter and a 32-electrode EIT device. Within 48 hours after the start of mechanical ventilation, different levels of PEEP were applied based upon PEEP/ Fraction of inspired oxygen tables, positive end-expiratory transpulmonary (PL)/ FiO2 table, and EIT. Respiratory mechanics variables were recorded.
Study Design
Outcome Measures
Primary Outcome Measures
- Value of PEEP [a single determination, within 24-48 hours after mechanical ventilation initiation]
different PEEP values obtained through using different methods
Secondary Outcome Measures
- Respiratory mechanics [a single determination, within 24-48 hours after mechanical ventilation initiation]
Respiratory mechanics (plateau pressure, driving pressure, compliance, mechanical power) following different PEEP settings
Eligibility Criteria
Criteria
Inclusion Criteria:
- COVID19-related ARDS under invasive mechanical ventilation
Exclusion Criteria:
- none
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Service de Réanimation Médicale, Hôpital Central | Nancy | France |
Sponsors and Collaborators
- Central Hospital, Nancy, France
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2021PI117