Association Between Periodontitis and the Level of Anti-citrullinated Protein Antibodies in Rheumatoid Arthritis
Study Details
Study Description
Brief Summary
the relationship between rheumatoid arthritis and periodontal disease is crucial and has been explained via a complex interplay of genetic, environmental, and hormonal factors that influence the host immune tolerance leading to both disease characteristics. The aim of this study is to clinically investigate the correlation between the levels of anti-citrullinated protein antibodies (ACPAs) in gingival crevicular fluid before and after non-surgical periodontal treatment and the severity of periodontal disease and rheumatoid arthritis in rheumatoid arthritis (RA) patients
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Detailed Description
the relationship between rheumatoid arthritis and periodontal disease is crucial and has been explained via a complex interplay of genetic, environmental, and hormonal factors that influence the host immune tolerance leading to both disease characteristics.
The aim of this study is to clinically investigate the correlation between the levels of anti-citrullinated protein antibodies (ACPAs) in gingival crevicular fluid before and after non-surgical periodontal treatment and the severity of periodontal disease and rheumatoid arthritis in rheumatoid arthritis (RA) patients Materials and Methods: a total of 40 participants suffering from periodontitis and rheumatoid arthritis will be referred from the Badr Hospital (Faculty of Medicine, Helwan University) to Misr international university's dental clinic complex. Gingival crevicular fluid (GCF) samples will be collected from the patients before performing periodontal therapy (baseline). Assessment of ACPAs will be quantified using enzyme-linked immunoassay (ELISA) as the primary outcome at baseline and after 3 months. Assessment of 2ry outcomes includes clinical periodontal and RA parameters at baseline and after 3 months.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Other: Non-surgical periodontal treatment assessment of different periodontal parameters and gingival crevicular fluid sampling will be done then non surgical periodontal treatment will be performed then after 3 months re assessment of the periodontal parameters and gingival crevicular fluid sampling will be done |
Other: Non surgical periodontal treatment
Non-surgical periodontal treatment will be performed using ultrasonic scaler and subgingival curettes
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Outcome Measures
Primary Outcome Measures
- Change in the level of anti-citrullinated protein antibodies (ACPAs) [at baseline and 3 months]
assessment of the level of anti-citrullinated protein antibodies (ACPAs) in gingival crevicular fluid
Secondary Outcome Measures
- Change in Clinical attachment Loss [at baseline and 3 months]
measuring the distance from the cemento enamel junction to the base of the pocket in mm
- Change in Probing depth [at baseline and 3 months]
measuring the distance from the gingival margin to the base of the pocket in mm
- Change in Plaque index (PI) [at baseline and 3 months]
it is a score (0,1,2 and 3) where: 0 = No plaque in the gingival area. 1 = A film of plaque adhering to the free gingival margin and adjacent area of the tooth. The plaque may only be recognized by running a probe across the tooth surface. 2 = Moderate accumulation of soft deposits within the gingival pocket, on the gingival margin and/or adjacent tooth surface, which can be seen by the naked eye. 3 = Abundance of soft matter within the gingival pocket and/or on the gingival margin and adjacent tooth surface
Eligibility Criteria
Criteria
Inclusion Criteria:
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Rheumatoid patients fulfilling the ACR criteria for the classification of RA
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18 years
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Both genders
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Presence of at least 8 teeth
Exclusion Criteria:
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Smoking
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Diabetes Mellitus
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Pregnant females
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Patients who had undergone periodontal treatment within last 3 months
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Antibiotic therapy during last 3 months
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Other autoimmune diseases
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Faculty of oral and dental medicine, Misr international university | Cairo | Egypt | 12345 |
Sponsors and Collaborators
- Misr International University
Investigators
- Principal Investigator: Zainab Hafez, Lecturer, Lecturer, faculty of oral and dental medicine misr international university
- Principal Investigator: Yahia Hassan, Lecturer, Lecturer, faculty of oral and dental medicine misr international university
- Study Director: Shahinaz Al ashiry, asso.Prof, Associate Professor, faculty of oral and dental medicine misr international universit
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- PER 3312007