Periodontal and Salivary Evaluation of Type 1 Diabetes Mellitus Patients
Study Details
Study Description
Brief Summary
Diabetes Mellitus is a risk factor for periodontal disease increasing its prevalence, extension and severity. Periodontal disease is considered the sixth complication of diabetes. There is a global epidemic of diabetes, including an increase of incidence of type 1 diabetes in younger patients. Thus, the aim of this observational study was to evaluate the periodontal and salivary condition of a sample of patients with type 1 diabetes of a brazillian city.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
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Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Test group Patients with Type 1 diabetes mellitus |
|
| Control Group Patients without systemic diseases |
Outcome Measures
Primary Outcome Measures
- Periodontal disease (gingivitis and periodontitis) measured by a periodontal probe and classified according to severity [one day]
Severe periodontitis was defined by the presence of ≥ 2 interproximal sites in different teeth with CAL (clinical attachment level) ≥ 6mm and ≥1 interproximal site with PPD (periodontal probing depth) ≥5mm. Moderate periodontitis was defined by the presence of ≥ 2 interproximal sites in different teeth with CAL ≥ 4mm or ≥ 2 interproximal sites in different teeth with PPD ≥5mm. Mild periodontitis was defined as ≥ 2 interproximal sites in different teeth with ≥ 3 mm CAL and ≥ 2 interproximal sites in different teeth with ≥ 4 mm PPD or at least 1 site with PPD ≥ 5 mm (20,21). Gingivitis was determined as follows: Subjects were considered healthy if presented PPD ≤3mm/BOP (bleeding on probing) extent scores < 10% and with gingivitis if presented PPD ≤3mm/ BOP extent scores >10%.
- Salivary pH and buffering Capacity - collection of stimulated saliva in 10 minutes and measurement of acidity with a pHmeter [one day]
Normal Salivary pH = 6 to 7. Buffering capacity: ≥ 5.6 were considered as ''high'', ranging from 4.1 to 5.5 were labelled as ''medium'' and those ≤4 were defined as ''low''
- Salivary glucose - collection of stimulated saliva in 10 minutes and measurement with a colorimetric kit [one day]
Salivary glucose is measured by a colorimetric kit and the values are converted and presented as mg/dL. There are no reference value for this measurement. The analysis is done by means of correlation to blood glucose levels in mg/dL.
- Salivary peroxidase - collection of stimulated saliva in 10 minutes, measurement by a spectrophotometer. [one day]
The activity of salivary peroxidase is presented in Units/mg. The detection of activity of these enzymes is associated to periodontal disease.
Secondary Outcome Measures
- Plaque index - measured by visual observation and classification in scores (1 for presence, 0 for absence) [One day]
Plaque index (PI) will be registered as scores (1 for presence, 0 for absence). For control group a plaque index of 15% is considered normal.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Diagnose of Type 1 diabetes mellitus
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Age between 18 and 35 years old
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Presenting on tooth per quadrant
Exclusion Criteria:
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Diagnose of Type 2 diabetes mellitus
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Edentulous patients
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Other systemic diseases
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Bauru School of Dentistry | Bauru | Sao Paulo | Brazil | 17012-901 |
Sponsors and Collaborators
- University of Sao Paulo
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
- Bauru School of Dentistry