PET MRI in Coronary Artery Disease
Study Details
Study Description
Brief Summary
This study will assess the use of position emission tomography/magnetic resonance imaging (PET/MRI) using ultra-small-superparamagnetic particles of iron oxide (USPIO) as a contrast agent in patients with coronary artery disease.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Positron emission tomography/magnetic resonance imaging (PET/MRI) has the potential to provide detailed information on coronary artery anatomy, the presence of coronary artery stenosis, the composition of atherosclerotic plaque using MRI tissue characterisation and information about the underlying biological processes using targeted PET tracers. Ultra-small-superparamagnetic particles of iron oxide (USPIO) have a long blood pool half-life so are an ideal contrast agent for PET/MRI imaging.
This study will assess the use of PET/MRI with USPIO in patients with stable coronary artery disease and recent acute myocardial infarction.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Healthy volunteers Healthy volunteers to undergo MRI using USPIO contrast |
Diagnostic Test: MRI
MRI with USPIO contrast
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Stable coronary artery disease Patients with coronary artery disease without recent (3 months) acute coronary syndrome or revascularisation |
Diagnostic Test: PET/MRI
PET/MRI with USPIO contrast
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Recent acute coronary syndrome Patients with recent (3 months) type 1 myocardial infarction |
Diagnostic Test: PET/MRI
PET/MRI with USPIO contrast
|
Outcome Measures
Primary Outcome Measures
- PET/MRI findings [Immediately after PET/MRI scan]
The primary endpoint will be the difference in MRI and PET characteristics of atherosclerotic plaques in patients with and without recent acute coronary syndromes.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Healthy volunteers to undergo MRI imaging will be over the age of 18 years and able to provide informed consent.
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Patients with coronary artery disease to undergo PET/MRI will have multi-vessel disease (≥2 vessel coronary artery disease with ≥ 50% cross-sectional luminal stenosis).
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able to provide informed consent
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over the age of 40 years
Exclusion Criteria:
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inability or unwillingness to undergo magnetic resonance imaging or positron emission tomography
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renal failure (Serum creatinine >200 umol/L or estimated glomerular filtration rate <30 mL/min
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hepatic failure
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pregnancy
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inability to provide informed consent
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contraindications to undergoing MRI scanning
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contraindications to contrast agents not included above including evidence of iron overload, known allergy to constituents of the contrast agents, and anaemia not caused by iron deficiency
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Royal Infirmary of Edinburgh | Edinburgh | Scotland | United Kingdom |
Sponsors and Collaborators
- University of Edinburgh
Investigators
- Principal Investigator: Michelle Williams, University of Edinburgh
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 17/SS/0151