PET/CT in Psoriatic Arthritis

Sponsor

University of Pennsylvania (Other)

Overall Status

Completed

CT.gov ID

NCT01654198

Collaborator

(none)

Enrollment

Location

Actual Duration (Months)

0.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

When patients with psoriasis develop joint pain, it is often hard to decide whether or not the pain is due to psoriatic arthritis (PsA). At this time, doctors use information from the history and physical exam to determine the diagnosis. X-rays, magnetic resonance imaging (MRI) and ultrasound have been used to help with the diagnosis but all three have limitations. A newer imaging technique, whole body Positron Emission Tomography/Computed Tomography (PET/CT) uses the idea that inflammatory cells take up sugar to locate inflammation in the body. Because patients with PsA have inflammatory cells in their joints and tendons, this type of scan allows the physician to take a picture of the whole body and locate inflammation. The investigators have found that some patients with psoriasis (but without arthritis) have inflammation in joints and tendons even before the patient has symptoms. In this study, the investigators will explore how well PET/CT works for assessing inflammation in patients with PsA. This would be a very exciting tool that could be used to find and treat inflammation before it causes damage or pain.

Condition or Disease	Intervention/Treatment	Phase
Psoriatic Arthritis	Radiation: FDG-PET/CT scan

Study Design

Study Type:

Observational

Actual Enrollment :

12 participants

Observational Model:

Case-Only

Time Perspective:

Cross-Sectional

Official Title:

FDG-PET/CT in the Diagnosis and Monitoring of Psoriatic Arthritis

Actual Study Start Date :

Jul 1, 2012

Actual Primary Completion Date :

Oct 2, 2018

Actual Study Completion Date :

Oct 2, 2018

Arms and Interventions

Arm	Intervention/Treatment
Psoriatic arthritis	Radiation: FDG-PET/CT scan FDG-PET/CT is a type of imaging used currently to look for cancer. We are using it to look at inflammation within the joints.

Arm

Intervention/Treatment

Psoriatic arthritis

Radiation: FDG-PET/CT scan

FDG-PET/CT is a type of imaging used currently to look for cancer. We are using it to look at inflammation within the joints.

Outcome Measures

Primary Outcome Measures

Primary outcome is inflammation as measured by SUVmax and metabolic volumetric product in the joints and entheses. [At the discretion of the PI]

Secondary Outcome Measures

Correlation of local inflammation in joints and enthesis with systemic inflammatory markers including IL6 and high sensitivity CRP. [At the discretion of the PI]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 80 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Age 18-80,
active psoriatic arthritis (joint or enthesis inflammation)

Exclusion Criteria:

Diabetes,
pregnant,
no active PsA

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Pennsylvania Division of Rheumatology	Philadelphia	Pennsylvania	United States	19104

Sponsors and Collaborators

University of Pennsylvania

Investigators

Principal Investigator: Alexis R Ogdie, MD, MSCE, University of Pennsylvania

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

University of Pennsylvania

ClinicalTrials.gov Identifier:

NCT01654198

Other Study ID Numbers:

815253

First Posted:

Jul 31, 2012

Last Update Posted:

Dec 8, 2020

Last Verified:

Dec 1, 2020

Additional relevant MeSH terms:

Arthritis

Arthritis, Psoriatic

Study Results

No Results Posted as of Dec 8, 2020