Pituitary Function and Spontaneous Intracranial Hypotension
Previous research has identified spontaneous cerebral spinal fluid leakage as a cause for spontaneous intracranial hypotension, leading to positional headache patterns. Typical magnetic resonance imaging findings include subdural fluid collections, enhancement of pachymenginges, engorgement of venous structures, pituitary hyperemia, and sagging of the brain (SEEPS). Because pituitary hyperemia has been documented in cases of spontaneous cerebral spinal fluid leakage and is known to mimic a pituitary tumor or hyperplasia, the investigators would like to like to assess the clinical manifestations and neuroimaging abnormalities of SIH patients with regard to the pituitary gland. Specifically, the investigators are looking to analyze the compression of the pituitary stalk and conduct a systemic evaluation of pituitary function in SIH patients.
Arms and Interventions
|Surgery or Blood Patch
Other: Pituitary panel will be drawn pre-op and post-op for all patients.
Primary Outcome Measures
- Comparing the levels of prolactin pre and post treatment [90 days]
Male or female patients
Age 18 years and older
Diagnosis of SIH:
Brain MRI (SEEPS)
Pregnant and post-partum females
Patients with potential hyperprolactinemia due to:
Chronic renal disorder
Liver disease (including cirrhosis)
Primary or secondary amenorrhea
Polycystic Ovary Syndrome
Illicit drug use
Contacts and Locations
|1||Cedars-Sinai Medical Center||Los Angeles||California||United States||90048|
Sponsors and Collaborators
- Cedars-Sinai Medical Center
- Principal Investigator: Vivien Bonert, MD, Cedars-Sinai Medical Center
Study Documents (Full-Text)None provided.
- Mokri B. Cerebrospinal fluid volume depletion and its emerging clinical/imaging syndromes. Neurosurg Focus. 2000 Jul 15;9(1):e6. Review.
- SCHALTENBRAND G. Normal and pathological physiology of the cerebrospinal fluid circulation. Lancet. 1953 Apr 25;1(6765):805-8.
- Schievink WI. Spontaneous spinal cerebrospinal fluid leaks and intracranial hypotension. JAMA. 2006 May 17;295(19):2286-96. Review.