Pleural Effusion Drainage in Mechanically Ventilated Patients Monitored by EIT
Study Details
Study Description
Brief Summary
Evacuation of pleural effusion (PE) represents a disputable therapy in mechanically ventilated patients. Patients on mechanical ventilation indicated by the physician to pleural fluid evacuation will be monitored throughout the procedure by electrical impedance tomography (EIT) and concurrently end-expiratory lung volume (EELV) will be measured in order to describe impact of PE evacuation on aeration and ventilation of the lungs.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Critically ill patients treated in intensive care units have a disorder of distribution and volume of body fluids due to principal illness and some therapeutic interventions. One of its manifestations is pleural effusion (PE) formation.
Patients on mechanical ventilation indicated by treating physician to pleural fluid evacuation will be monitored throughout the procedure by electrical impedance tomography (EIT) and concurrently end-expiratory lung volume (EELV) will be measured. The purpose of the study is to better understand impact of PE evacuation on aeration and ventilation of the lungs.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Electrical Impedance Tomography record Electrical Impedance Tomography monitoring of the pleural effusion evacuation. |
Device: Electrical Impedance Tomography record
Monitoring of pleural effusion evacuation by means of EIT
|
Outcome Measures
Primary Outcome Measures
- Change of the thorax electrical impedance following pleural effusion drainage in mechanically ventilated patients [4 hours]
Comparison of EIT results with end-expiratory lung volume measurement during drainage of pleural effusion
Secondary Outcome Measures
- Change of the distribution of ventilation following pleural effusion drainage in mechanically ventilated patients [4 hours]
Change of distribution of ventilation over EIT regions of interest (ROIs)
Eligibility Criteria
Criteria
Inclusion Criteria:
- mechanical ventilation, presence of pleural effusion, decision of the treating physician to drain it
Exclusion Criteria:
-
impossibility to apply EIT belt or to find suitable save point for drainage when the EIT belt is attached
-
standard EIT exclusion criteria according to the device manufacturer
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | The Military University Hospital | Prague | Czechia | 16902 |
Sponsors and Collaborators
- Czech Technical University in Prague
- Military University Hospital, Prague
Investigators
- Principal Investigator: Karel Roubik, Prof., PhD., Czech Technical University in Prague
Study Documents (Full-Text)
None provided.More Information
Publications
- Alves SH, Amato MB, Terra RM, Vargas FS, Caruso P. Lung reaeration and reventilation after aspiration of pleural effusions. A study using electrical impedance tomography. Ann Am Thorac Soc. 2014 Feb;11(2):186-91. doi: 10.1513/AnnalsATS.201306-142OC.
- Goligher EC, Leis JA, Fowler RA, Pinto R, Adhikari NK, Ferguson ND. Utility and safety of draining pleural effusions in mechanically ventilated patients: a systematic review and meta-analysis. Crit Care. 2011;15(1):R46. doi: 10.1186/cc10009. Epub 2011 Feb 2. Review.
- Mattison LE, Coppage L, Alderman DF, Herlong JO, Sahn SA. Pleural effusions in the medical ICU: prevalence, causes, and clinical implications. Chest. 1997 Apr;111(4):1018-23.
- Razazi K, Thille AW, Carteaux G, Beji O, Brun-Buisson C, Brochard L, Mekontso Dessap A. Effects of pleural effusion drainage on oxygenation, respiratory mechanics, and hemodynamics in mechanically ventilated patients. Ann Am Thorac Soc. 2014 Sep;11(7):1018-24. doi: 10.1513/AnnalsATS.201404-152OC.
- Ventilation-EIT-PE