Population-based Age-stratified Seroepidemiological Investigation Protocol for Coronavirus 2019 (COVID-19) Infection in the Federation of Bosnia and Herzegovina
This study is the second cross-sectional study conducted in the region. In the first cross sectional study, conducted in the winter of 2020, we aimed to estimate the seroprevalence of SARS-CoV-2 IgG antibodies among blood donors in Sarajevo Canton. We also assessed immune durability among seropositive participants after 6 months. In total, of 1015 blood donors aged 18-65 years in Sarajevo Canton between 2 November and 3 December 2020 were recruited and population-weighted seroprevalence in Sarajevo Canton was 19.2% (95% CI: 16.7-21.6%). The aim of this second cross-sectional study is to measure the seroprevalence SARS-CoV-2 antibodies and assess antibody kinetics in the blood donor population after 12 months.
Arms and Interventions
|Persons aged 18-29|
|Persons aged 30-39|
|Persons aged 40-65|
Primary Outcome Measures
- Seroprevalence of SARS-CoV-2 IgG antibodies [November 2021-December 2021]
Crude seroprevalence among blood donors will be adjusted to age and sex distribution in cantonal population and to test sensitivity and specificity using Bayesian statistical modeling.
Secondary Outcome Measures
- Assess factors associated with seropositivity. [November 2021-December 2021]
Chi-squared test will be conducted on categorical variables.
- Assess antibody response across types of immunity. [November 2021-December 2021]
Among those with positive anti-S antibodies, geometric mean titers will be compared across participants with natural immunity, vaccine-induced immunity, and hybrid of natural and vaccine-induced immunity.
- All individuals identified for recruitment into the investigation, resident of Canton Sarajevo between 18-65 years, irrespective of prior COVID-19 infection.
- Refusal to give informed consent or to attend follow-up appointments; currently experiencing COVID-19 symptoms or in the last 14 days; and close contact with a confirmed case of COVID-19 within 14 days prior to donation.
Contacts and Locations
|1||Institute for Transfusion Medicine of the Federation of Bosnia and Herzegovina||Sarajevo||Bosnia and Herzegovina||71000|
Sponsors and Collaborators
- Institute for Public Health of the Federation of Bosnia and Herzegovina
- World Health Organization
Study Documents (Full-Text)None provided.